Corneal hysteresis and corneal resistance factor in pellucid marginal degeneration
Purpose: To evaluate and compare corneal hysteresis (CH) and corneal resistance factor (CRF) in pellucid marginal degeneration (PMD), keratoconus (KCN), and normal eyes using the Ocular Response Analyzer (ORA). Methods: In this retrospective study, corneal biomechanical parameters were measured in p...
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Wolters Kluwer Medknow Publications
2018-03-01
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| Series: | Journal of Current Ophthalmology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452232517300823 |
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| author | Mohamad Reza Sedaghat Hadi Ostadi-Moghadam Mahmoud Jabbarvand Farshad Askarizadeh Hamed Momeni-Moghaddam Foroozan Narooie-Noori |
| author_facet | Mohamad Reza Sedaghat Hadi Ostadi-Moghadam Mahmoud Jabbarvand Farshad Askarizadeh Hamed Momeni-Moghaddam Foroozan Narooie-Noori |
| author_sort | Mohamad Reza Sedaghat |
| collection | DOAJ |
| description | Purpose: To evaluate and compare corneal hysteresis (CH) and corneal resistance factor (CRF) in pellucid marginal degeneration (PMD), keratoconus (KCN), and normal eyes using the Ocular Response Analyzer (ORA).
Methods: In this retrospective study, corneal biomechanical parameters were measured in patients with PMD (n = 102) and KCN (n = 202) and normal subjects (n = 208) using the ORA. Data, including full patient history as well as the results of refraction, slit-lamp biomicroscopy, Pentacam HR (Oculus), and ORA (Reichert; Buffalo, New York, USA), were collected from medical records. Also, the data of only one eye per individual were selected for the analysis. The inclusion criteria for PMD and KCN groups were a reliable diagnosis of these ectatic disorders based on the clinical and corneal tomographic findings. CH, CRF, CH–CRF, intraocular pressure (IOP) measurements were assessed for each subject. Data were analyzed with SPSS and MedCalc using the ANOVA, Pearson Correlation, and receiver operating characteristic (ROC) curve analysis.
Results: The mean CH was 8.91 mmHg ± 1.05 [standard deviation (SD)], 8.43 ± 0.78, and 10.89 ± 1.08 in the PMD, KCN, and normal group, respectively. Also, the mean CRF was 8.21 ± 1.35, 7.19 ± 1.11, and 10.69 ± 1.41 in the PMD, KCN, and normal group, respectively. ANOVA showed differences in the mean CH, CRF, and CH–CRF between three groups (P < 0.001). Also, ROC curve analysis showed the cut-off points ≤9.5, ≤9.5, and >1.3 mmHg for CH, CRF, and CH–CRF in the PMD group, respectively. For biomechanical parameters in PMD eyes, CRF had the highest sensitivity (75.49%) while the greatest area under the ROC curve (AUC) was seen for CH (0.903). Moreover, central corneal thickness (CCT) showed no correlation with CH (P = 0.30, r = −0.104) or CRF (P = 0.75, r = 0.033) in the PMD group.
Conclusions: This study presented the values of corneal biomechanics for PMD using the ORA. The results of the ORA were markedly different between PMD, KCN, and normal eyes. |
| first_indexed | 2024-12-14T21:41:30Z |
| format | Article |
| id | doaj.art-feced515dd7040df9fb7694fcd146226 |
| institution | Directory Open Access Journal |
| issn | 2452-2325 |
| language | English |
| last_indexed | 2024-12-14T21:41:30Z |
| publishDate | 2018-03-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Current Ophthalmology |
| spelling | doaj.art-feced515dd7040df9fb7694fcd1462262022-12-21T22:46:28ZengWolters Kluwer Medknow PublicationsJournal of Current Ophthalmology2452-23252018-03-01301424710.1016/j.joco.2017.08.002Corneal hysteresis and corneal resistance factor in pellucid marginal degenerationMohamad Reza Sedaghat0Hadi Ostadi-Moghadam1Mahmoud Jabbarvand2Farshad Askarizadeh3Hamed Momeni-Moghaddam4Foroozan Narooie-Noori5Cornea Research Center, Khatam-Al-Anbia Hospital, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, IranOphthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, IranPurpose: To evaluate and compare corneal hysteresis (CH) and corneal resistance factor (CRF) in pellucid marginal degeneration (PMD), keratoconus (KCN), and normal eyes using the Ocular Response Analyzer (ORA). Methods: In this retrospective study, corneal biomechanical parameters were measured in patients with PMD (n = 102) and KCN (n = 202) and normal subjects (n = 208) using the ORA. Data, including full patient history as well as the results of refraction, slit-lamp biomicroscopy, Pentacam HR (Oculus), and ORA (Reichert; Buffalo, New York, USA), were collected from medical records. Also, the data of only one eye per individual were selected for the analysis. The inclusion criteria for PMD and KCN groups were a reliable diagnosis of these ectatic disorders based on the clinical and corneal tomographic findings. CH, CRF, CH–CRF, intraocular pressure (IOP) measurements were assessed for each subject. Data were analyzed with SPSS and MedCalc using the ANOVA, Pearson Correlation, and receiver operating characteristic (ROC) curve analysis. Results: The mean CH was 8.91 mmHg ± 1.05 [standard deviation (SD)], 8.43 ± 0.78, and 10.89 ± 1.08 in the PMD, KCN, and normal group, respectively. Also, the mean CRF was 8.21 ± 1.35, 7.19 ± 1.11, and 10.69 ± 1.41 in the PMD, KCN, and normal group, respectively. ANOVA showed differences in the mean CH, CRF, and CH–CRF between three groups (P < 0.001). Also, ROC curve analysis showed the cut-off points ≤9.5, ≤9.5, and >1.3 mmHg for CH, CRF, and CH–CRF in the PMD group, respectively. For biomechanical parameters in PMD eyes, CRF had the highest sensitivity (75.49%) while the greatest area under the ROC curve (AUC) was seen for CH (0.903). Moreover, central corneal thickness (CCT) showed no correlation with CH (P = 0.30, r = −0.104) or CRF (P = 0.75, r = 0.033) in the PMD group. Conclusions: This study presented the values of corneal biomechanics for PMD using the ORA. The results of the ORA were markedly different between PMD, KCN, and normal eyes.http://www.sciencedirect.com/science/article/pii/S2452232517300823Pellucid marginal degenerationCorneal biomechanicsCorneal hysteresisCorneal resistance factorKeratoconus |
| spellingShingle | Mohamad Reza Sedaghat Hadi Ostadi-Moghadam Mahmoud Jabbarvand Farshad Askarizadeh Hamed Momeni-Moghaddam Foroozan Narooie-Noori Corneal hysteresis and corneal resistance factor in pellucid marginal degeneration Journal of Current Ophthalmology Pellucid marginal degeneration Corneal biomechanics Corneal hysteresis Corneal resistance factor Keratoconus |
| title | Corneal hysteresis and corneal resistance factor in pellucid marginal degeneration |
| title_full | Corneal hysteresis and corneal resistance factor in pellucid marginal degeneration |
| title_fullStr | Corneal hysteresis and corneal resistance factor in pellucid marginal degeneration |
| title_full_unstemmed | Corneal hysteresis and corneal resistance factor in pellucid marginal degeneration |
| title_short | Corneal hysteresis and corneal resistance factor in pellucid marginal degeneration |
| title_sort | corneal hysteresis and corneal resistance factor in pellucid marginal degeneration |
| topic | Pellucid marginal degeneration Corneal biomechanics Corneal hysteresis Corneal resistance factor Keratoconus |
| url | http://www.sciencedirect.com/science/article/pii/S2452232517300823 |
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