The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial
Abstract Background Emerging evidence showed promising effects of vitamin D on headaches characteristics. Thus, it seems there is still a need for more researches to clarify the mechanisms by which this vitamin exerts anti-migraine effects. Methods The present study was conducted as a 16-week random...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s10194-020-01090-w |
| _version_ | 1818873001967353856 |
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| author | Zeinab Ghorbani Pegah Rafiee Akbar Fotouhi Samane Haghighi Reyhaneh Rasekh Magham Zeynab Sadat Ahmadi Mahmoud Djalali Mahnaz Zareei Soodeh Razeghi Jahromi Sahar Shahemi Maryam Mahmoudi Mansoureh Togha |
| author_facet | Zeinab Ghorbani Pegah Rafiee Akbar Fotouhi Samane Haghighi Reyhaneh Rasekh Magham Zeynab Sadat Ahmadi Mahmoud Djalali Mahnaz Zareei Soodeh Razeghi Jahromi Sahar Shahemi Maryam Mahmoudi Mansoureh Togha |
| author_sort | Zeinab Ghorbani |
| collection | DOAJ |
| description | Abstract Background Emerging evidence showed promising effects of vitamin D on headaches characteristics. Thus, it seems there is still a need for more researches to clarify the mechanisms by which this vitamin exerts anti-migraine effects. Methods The present study was conducted as a 16-week randomized double-blind placebo-controlled trial on 80 episodic migraine patients allocated in 2 parallel groups each consisted of 40 patients who received vitamin D 2000 IU/d or placebo. At baseline and after the intervention completion, headache diaries and migraine disability assessment questionnaire (MIDAS) were used to assess migraine related variables in patients. Also, interictal serum concentration of calcitonin gene-related peptide (CGRP) (as the dominant mediator of migraine pain pathogenesis) was evaluated using ELISA method. Results The mean (SD) of age in the vitamin D and placebo groups was 37 (8) and 38 (12) years, respectively. ANCOVA test adjusted for baseline values, and confounders showed vitamin D supplementation resulted in a significant improvement in MIDAS score after 12 weeks in the intervention group (21.49 (16.22–26.77)) compared to placebo (31.16 (25.51–36.82) P value: 0.016). Moreover, after controlling for baseline levels, and other variables using ANCOVA, CGRP level was appeared to be significantly lower following vitamin D supplementation (153.26 (133.03–173.49) ng/L) than the patients in the placebo arm (188.35 (167.15–209.54) ng/L) (P value = 0.022). Conclusion According to the current findings, vitamin D supplementation in episodic migraineurs, particularly in those with migraine with aura, may potentially improve migraine headache characteristics and disability probably through attenuating CGRP levels. Therefore, these results could provide a new insight into anti-nociceptive effects of vitamin D; however, more studies are required to confirm our findings. Trial registration The trial is registered in the Iranian registry of clinical trials (IRCT) at 11 July 2018, with IRCT code: IRCT20151128025267N6 . |
| first_indexed | 2024-12-19T12:47:46Z |
| format | Article |
| id | doaj.art-fed04b3c9a764c98912b6d178833a734 |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-12-19T12:47:46Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-fed04b3c9a764c98912b6d178833a7342022-12-21T20:20:42ZengBMCThe Journal of Headache and Pain1129-23691129-23772020-02-0121111310.1186/s10194-020-01090-wThe effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trialZeinab Ghorbani0Pegah Rafiee1Akbar Fotouhi2Samane Haghighi3Reyhaneh Rasekh Magham4Zeynab Sadat Ahmadi5Mahmoud Djalali6Mahnaz Zareei7Soodeh Razeghi Jahromi8Sahar Shahemi9Maryam Mahmoudi10Mansoureh Togha11Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesStudent Research Committee, Department and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical SciencesDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical SciencesHeadache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical SciencesDepartment of Nutrition, Faculty of Medical Sciences, Science and Research Branch, Islamic Azad UniversityDepartment of Nutrition, School of Health, Iran University of Medical SciencesDepartment of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical SciencesDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical SciencesDepartment of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesHeadache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical SciencesAbstract Background Emerging evidence showed promising effects of vitamin D on headaches characteristics. Thus, it seems there is still a need for more researches to clarify the mechanisms by which this vitamin exerts anti-migraine effects. Methods The present study was conducted as a 16-week randomized double-blind placebo-controlled trial on 80 episodic migraine patients allocated in 2 parallel groups each consisted of 40 patients who received vitamin D 2000 IU/d or placebo. At baseline and after the intervention completion, headache diaries and migraine disability assessment questionnaire (MIDAS) were used to assess migraine related variables in patients. Also, interictal serum concentration of calcitonin gene-related peptide (CGRP) (as the dominant mediator of migraine pain pathogenesis) was evaluated using ELISA method. Results The mean (SD) of age in the vitamin D and placebo groups was 37 (8) and 38 (12) years, respectively. ANCOVA test adjusted for baseline values, and confounders showed vitamin D supplementation resulted in a significant improvement in MIDAS score after 12 weeks in the intervention group (21.49 (16.22–26.77)) compared to placebo (31.16 (25.51–36.82) P value: 0.016). Moreover, after controlling for baseline levels, and other variables using ANCOVA, CGRP level was appeared to be significantly lower following vitamin D supplementation (153.26 (133.03–173.49) ng/L) than the patients in the placebo arm (188.35 (167.15–209.54) ng/L) (P value = 0.022). Conclusion According to the current findings, vitamin D supplementation in episodic migraineurs, particularly in those with migraine with aura, may potentially improve migraine headache characteristics and disability probably through attenuating CGRP levels. Therefore, these results could provide a new insight into anti-nociceptive effects of vitamin D; however, more studies are required to confirm our findings. Trial registration The trial is registered in the Iranian registry of clinical trials (IRCT) at 11 July 2018, with IRCT code: IRCT20151128025267N6 .http://link.springer.com/article/10.1186/s10194-020-01090-wCholecalciferolDisabilityHeadacheCGRPMigraine with Aura |
| spellingShingle | Zeinab Ghorbani Pegah Rafiee Akbar Fotouhi Samane Haghighi Reyhaneh Rasekh Magham Zeynab Sadat Ahmadi Mahmoud Djalali Mahnaz Zareei Soodeh Razeghi Jahromi Sahar Shahemi Maryam Mahmoudi Mansoureh Togha The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial The Journal of Headache and Pain Cholecalciferol Disability Headache CGRP Migraine with Aura |
| title | The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial |
| title_full | The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial |
| title_fullStr | The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial |
| title_full_unstemmed | The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial |
| title_short | The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial |
| title_sort | effects of vitamin d supplementation on interictal serum levels of calcitonin gene related peptide cgrp in episodic migraine patients post hoc analysis of a randomized double blind placebo controlled trial |
| topic | Cholecalciferol Disability Headache CGRP Migraine with Aura |
| url | http://link.springer.com/article/10.1186/s10194-020-01090-w |
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