Experimental and virtual testing of bone-implant systems equipped with the AO Fracture Monitor with regard to interfragmentary movement
Introduction: The management of fractured bones is a key domain within orthopedic trauma surgery, with the prevention of delayed healing and non-unions forming a core challenge. This study evaluates the efficacy of the AO Fracture Monitor in conjunction with biomechanical simulations to better under...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1370837/full |
| _version_ | 1797268671497764864 |
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| author | Kerstin Wickert Michael Roland Annchristin Andres Stefan Diebels Bergita Ganse Dorothea Kerner Felix Frenzel Thomas Tschernig Manuela Ernst Markus Windolf Max Müller Tim Pohlemann Marcel Orth |
| author_facet | Kerstin Wickert Michael Roland Annchristin Andres Stefan Diebels Bergita Ganse Dorothea Kerner Felix Frenzel Thomas Tschernig Manuela Ernst Markus Windolf Max Müller Tim Pohlemann Marcel Orth |
| author_sort | Kerstin Wickert |
| collection | DOAJ |
| description | Introduction: The management of fractured bones is a key domain within orthopedic trauma surgery, with the prevention of delayed healing and non-unions forming a core challenge. This study evaluates the efficacy of the AO Fracture Monitor in conjunction with biomechanical simulations to better understand the local mechanics of fracture gaps, which is crucial for comprehending mechanotransduction, a key factor in bone healing. Through a series of experiments and corresponding simulations, the study tests four hypotheses to determine the relationship between physical measurements and the predictive power of biomechanical models.Methods: Employing the AO Fracture Monitor and Digital Image Correlation techniques, the study demonstrates a significant correlation between the surface strain of implants and interfragmentary movements. This provides a foundation for utilizing one-dimensional AO Fracture Monitor measurements to predict three-dimensional fracture behavior, thereby linking mechanical loading with fracture gap dynamics. Moreover, the research establishes that finite element simulations of bone-implant systems can be effectively validated using experimental data, underpinning the accuracy of simulations in replicating physical behaviors.Results and Discussion: The findings endorse the combined use of monitoring technologies and simulations to infer the local mechanical conditions at the fracture site, offering a potential leap in personalized therapy for bone healing. Clinically, this approach can enhance treatment outcomes by refining the assessment precision in trauma trials, fostering the early detection of healing disturbances, and guiding improvements in future implant design. Ultimately, this study paves the way for more sophisticated patient monitoring and tailored interventions, promising to elevate the standard of care in orthopedic trauma surgery. |
| first_indexed | 2024-04-25T01:36:11Z |
| format | Article |
| id | doaj.art-fed08b36ac3648f695a14241100fff74 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-25T01:36:11Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-fed08b36ac3648f695a14241100fff742024-03-08T09:51:30ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-03-011210.3389/fbioe.2024.13708371370837Experimental and virtual testing of bone-implant systems equipped with the AO Fracture Monitor with regard to interfragmentary movementKerstin Wickert0Michael Roland1Annchristin Andres2Stefan Diebels3Bergita Ganse4Dorothea Kerner5Felix Frenzel6Thomas Tschernig7Manuela Ernst8Markus Windolf9Max Müller10Tim Pohlemann11Marcel Orth12Applied Mechanics, Saarland University, Saarbrücken, GermanyApplied Mechanics, Saarland University, Saarbrücken, GermanyApplied Mechanics, Saarland University, Saarbrücken, GermanyApplied Mechanics, Saarland University, Saarbrücken, GermanyWerner Siemens Endowed Chair of Innovative Implant Development (Fracture Healing), Saarland University, Homburg, GermanyClinic of Diagnostic and Interventional Radiology, Saarland University Hospital, Homburg, GermanyClinic of Diagnostic and Interventional Radiology, Saarland University Hospital, Homburg, GermanyInstitute of Anatomy and Cell Biology, Saarland University, Homburg, GermanyAO Research Institute Davos (ARI), Davos, SwitzerlandAO Research Institute Davos (ARI), Davos, SwitzerlandDepartment of Trauma, Hand and Reconstruction Surgery, Saarland University Hospital, Homburg, GermanyDepartment of Trauma, Hand and Reconstruction Surgery, Saarland University Hospital, Homburg, GermanyDepartment of Trauma, Hand and Reconstruction Surgery, Saarland University Hospital, Homburg, GermanyIntroduction: The management of fractured bones is a key domain within orthopedic trauma surgery, with the prevention of delayed healing and non-unions forming a core challenge. This study evaluates the efficacy of the AO Fracture Monitor in conjunction with biomechanical simulations to better understand the local mechanics of fracture gaps, which is crucial for comprehending mechanotransduction, a key factor in bone healing. Through a series of experiments and corresponding simulations, the study tests four hypotheses to determine the relationship between physical measurements and the predictive power of biomechanical models.Methods: Employing the AO Fracture Monitor and Digital Image Correlation techniques, the study demonstrates a significant correlation between the surface strain of implants and interfragmentary movements. This provides a foundation for utilizing one-dimensional AO Fracture Monitor measurements to predict three-dimensional fracture behavior, thereby linking mechanical loading with fracture gap dynamics. Moreover, the research establishes that finite element simulations of bone-implant systems can be effectively validated using experimental data, underpinning the accuracy of simulations in replicating physical behaviors.Results and Discussion: The findings endorse the combined use of monitoring technologies and simulations to infer the local mechanical conditions at the fracture site, offering a potential leap in personalized therapy for bone healing. Clinically, this approach can enhance treatment outcomes by refining the assessment precision in trauma trials, fostering the early detection of healing disturbances, and guiding improvements in future implant design. Ultimately, this study paves the way for more sophisticated patient monitoring and tailored interventions, promising to elevate the standard of care in orthopedic trauma surgery.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1370837/fullexperimental biomechanicsbiomechanical simulationbone healingorthopedic trauma surgeryosteosynthesissmart implant |
| spellingShingle | Kerstin Wickert Michael Roland Annchristin Andres Stefan Diebels Bergita Ganse Dorothea Kerner Felix Frenzel Thomas Tschernig Manuela Ernst Markus Windolf Max Müller Tim Pohlemann Marcel Orth Experimental and virtual testing of bone-implant systems equipped with the AO Fracture Monitor with regard to interfragmentary movement Frontiers in Bioengineering and Biotechnology experimental biomechanics biomechanical simulation bone healing orthopedic trauma surgery osteosynthesis smart implant |
| title | Experimental and virtual testing of bone-implant systems equipped with the AO Fracture Monitor with regard to interfragmentary movement |
| title_full | Experimental and virtual testing of bone-implant systems equipped with the AO Fracture Monitor with regard to interfragmentary movement |
| title_fullStr | Experimental and virtual testing of bone-implant systems equipped with the AO Fracture Monitor with regard to interfragmentary movement |
| title_full_unstemmed | Experimental and virtual testing of bone-implant systems equipped with the AO Fracture Monitor with regard to interfragmentary movement |
| title_short | Experimental and virtual testing of bone-implant systems equipped with the AO Fracture Monitor with regard to interfragmentary movement |
| title_sort | experimental and virtual testing of bone implant systems equipped with the ao fracture monitor with regard to interfragmentary movement |
| topic | experimental biomechanics biomechanical simulation bone healing orthopedic trauma surgery osteosynthesis smart implant |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1370837/full |
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