High-Risk Human Papillomavirus Oncogenic E6/E7 mRNAs Splicing Regulation
High-risk human papillomavirus infection may develop into a persistent infection that is highly related to the progression of various cancers, including cervical cancer and head and neck squamous cell carcinomas. The most common high-risk subtypes are HPV16 and HPV18. The oncogenic viral proteins ex...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.929666/full |
| _version_ | 1818157222787547136 |
|---|---|
| author | Yunji Zheng Xue Li Yisheng Jiao Chengjun Wu |
| author_facet | Yunji Zheng Xue Li Yisheng Jiao Chengjun Wu |
| author_sort | Yunji Zheng |
| collection | DOAJ |
| description | High-risk human papillomavirus infection may develop into a persistent infection that is highly related to the progression of various cancers, including cervical cancer and head and neck squamous cell carcinomas. The most common high-risk subtypes are HPV16 and HPV18. The oncogenic viral proteins expressed by high-risk HPVs E6/E7 are tightly involved in cell proliferation, differentiation, and cancerous transformation since E6/E7 mRNAs are derived from the same pre-mRNA. Hence, the alternative splicing in the E6/E7-coding region affects the balance of the E6/E7 expression level. Interrupting the balance of E6 and E7 levels results in cell apoptosis. Therefore, it is crucial to understand the regulation of E6/E7 splice site selection and the interaction of splicing enhancers and silencers with cellular splicing factors. In this review, we concluded the relationship of different E6/E7 transcripts with cancer progression, the known splicing sites, and the identified cis-regulatory elements within high-risk HPV E6/E7-coding region. Finally, we also reviewed the role of various splicing factors in the regulation of high-risk HPV oncogenic E6/E7 mRNA splicing. |
| first_indexed | 2024-12-11T15:10:46Z |
| format | Article |
| id | doaj.art-fed2a5a3fa6c481c88a4ddb62e05b708 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-11T15:10:46Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-fed2a5a3fa6c481c88a4ddb62e05b7082022-12-22T01:00:46ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-06-011210.3389/fcimb.2022.929666929666High-Risk Human Papillomavirus Oncogenic E6/E7 mRNAs Splicing RegulationYunji Zheng0Xue Li1Yisheng Jiao2Chengjun Wu3School of Pharmacy, Binzhou Medical University, Yantai, ChinaSchool of Pharmacy, Binzhou Medical University, Yantai, ChinaSchool of Biomedical Engineering, Dalian University of Technology, Dalian, ChinaSchool of Biomedical Engineering, Dalian University of Technology, Dalian, ChinaHigh-risk human papillomavirus infection may develop into a persistent infection that is highly related to the progression of various cancers, including cervical cancer and head and neck squamous cell carcinomas. The most common high-risk subtypes are HPV16 and HPV18. The oncogenic viral proteins expressed by high-risk HPVs E6/E7 are tightly involved in cell proliferation, differentiation, and cancerous transformation since E6/E7 mRNAs are derived from the same pre-mRNA. Hence, the alternative splicing in the E6/E7-coding region affects the balance of the E6/E7 expression level. Interrupting the balance of E6 and E7 levels results in cell apoptosis. Therefore, it is crucial to understand the regulation of E6/E7 splice site selection and the interaction of splicing enhancers and silencers with cellular splicing factors. In this review, we concluded the relationship of different E6/E7 transcripts with cancer progression, the known splicing sites, and the identified cis-regulatory elements within high-risk HPV E6/E7-coding region. Finally, we also reviewed the role of various splicing factors in the regulation of high-risk HPV oncogenic E6/E7 mRNA splicing.https://www.frontiersin.org/articles/10.3389/fcimb.2022.929666/fullhigh-risk HPVscervical cancerHNSCCE6/E7splicingsplicing factors |
| spellingShingle | Yunji Zheng Xue Li Yisheng Jiao Chengjun Wu High-Risk Human Papillomavirus Oncogenic E6/E7 mRNAs Splicing Regulation Frontiers in Cellular and Infection Microbiology high-risk HPVs cervical cancer HNSCC E6/E7 splicing splicing factors |
| title | High-Risk Human Papillomavirus Oncogenic E6/E7 mRNAs Splicing Regulation |
| title_full | High-Risk Human Papillomavirus Oncogenic E6/E7 mRNAs Splicing Regulation |
| title_fullStr | High-Risk Human Papillomavirus Oncogenic E6/E7 mRNAs Splicing Regulation |
| title_full_unstemmed | High-Risk Human Papillomavirus Oncogenic E6/E7 mRNAs Splicing Regulation |
| title_short | High-Risk Human Papillomavirus Oncogenic E6/E7 mRNAs Splicing Regulation |
| title_sort | high risk human papillomavirus oncogenic e6 e7 mrnas splicing regulation |
| topic | high-risk HPVs cervical cancer HNSCC E6/E7 splicing splicing factors |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.929666/full |
| work_keys_str_mv | AT yunjizheng highriskhumanpapillomavirusoncogenice6e7mrnassplicingregulation AT xueli highriskhumanpapillomavirusoncogenice6e7mrnassplicingregulation AT yishengjiao highriskhumanpapillomavirusoncogenice6e7mrnassplicingregulation AT chengjunwu highriskhumanpapillomavirusoncogenice6e7mrnassplicingregulation |