A Review on the Crosstalk between Insulin and Wnt/β-Catenin Signalling for Bone Health
A positive association between insulin resistance and osteoporosis has been widely established. However, crosstalk between the signalling molecules in insulin and Wingless (Wnt)/beta-(β-)catenin transduction cascades orchestrating bone homeostasis remains not well understood. The current review aims...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/15/12441 |
| _version_ | 1797586643500138496 |
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| author | Sok Kuan Wong Nur Vaizura Mohamad Putri Ayu Jayusman Nurul ‘Izzah Ibrahim |
| author_facet | Sok Kuan Wong Nur Vaizura Mohamad Putri Ayu Jayusman Nurul ‘Izzah Ibrahim |
| author_sort | Sok Kuan Wong |
| collection | DOAJ |
| description | A positive association between insulin resistance and osteoporosis has been widely established. However, crosstalk between the signalling molecules in insulin and Wingless (Wnt)/beta-(β-)catenin transduction cascades orchestrating bone homeostasis remains not well understood. The current review aims to collate the existing evidence, reporting (a) the expression of insulin signalling molecules involved in bone-related disorders and (b) the expression of Wnt/β-catenin signalling molecules involved in governing insulin homeostasis. The downstream effector molecule, glycogen synthase kinase-3 beta (GSK3β), has been identified to be a point of convergence linking the two signal transduction networks. This review highlights that GSK3β may be a drug target in the development of novel anabolic agents and the potential use of GSK3β inhibitors to treat bone-related disorders. |
| first_indexed | 2024-03-11T00:25:00Z |
| format | Article |
| id | doaj.art-fed313aab8174c39bd39296047a7fed1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T00:25:00Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fed313aab8174c39bd39296047a7fed12023-11-18T23:05:06ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124151244110.3390/ijms241512441A Review on the Crosstalk between Insulin and Wnt/β-Catenin Signalling for Bone HealthSok Kuan Wong0Nur Vaizura Mohamad1Putri Ayu Jayusman2Nurul ‘Izzah Ibrahim3Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, MalaysiaCentre for Drug and Herbal Development, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, MalaysiaDepartment of Craniofacial Diagnostics and Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, MalaysiaA positive association between insulin resistance and osteoporosis has been widely established. However, crosstalk between the signalling molecules in insulin and Wingless (Wnt)/beta-(β-)catenin transduction cascades orchestrating bone homeostasis remains not well understood. The current review aims to collate the existing evidence, reporting (a) the expression of insulin signalling molecules involved in bone-related disorders and (b) the expression of Wnt/β-catenin signalling molecules involved in governing insulin homeostasis. The downstream effector molecule, glycogen synthase kinase-3 beta (GSK3β), has been identified to be a point of convergence linking the two signal transduction networks. This review highlights that GSK3β may be a drug target in the development of novel anabolic agents and the potential use of GSK3β inhibitors to treat bone-related disorders.https://www.mdpi.com/1422-0067/24/15/12441bone lossglycogen synthase kinase-3 betaGSK3βtype 1 diabetes mellitustype 2 diabetes mellitus |
| spellingShingle | Sok Kuan Wong Nur Vaizura Mohamad Putri Ayu Jayusman Nurul ‘Izzah Ibrahim A Review on the Crosstalk between Insulin and Wnt/β-Catenin Signalling for Bone Health International Journal of Molecular Sciences bone loss glycogen synthase kinase-3 beta GSK3β type 1 diabetes mellitus type 2 diabetes mellitus |
| title | A Review on the Crosstalk between Insulin and Wnt/β-Catenin Signalling for Bone Health |
| title_full | A Review on the Crosstalk between Insulin and Wnt/β-Catenin Signalling for Bone Health |
| title_fullStr | A Review on the Crosstalk between Insulin and Wnt/β-Catenin Signalling for Bone Health |
| title_full_unstemmed | A Review on the Crosstalk between Insulin and Wnt/β-Catenin Signalling for Bone Health |
| title_short | A Review on the Crosstalk between Insulin and Wnt/β-Catenin Signalling for Bone Health |
| title_sort | review on the crosstalk between insulin and wnt β catenin signalling for bone health |
| topic | bone loss glycogen synthase kinase-3 beta GSK3β type 1 diabetes mellitus type 2 diabetes mellitus |
| url | https://www.mdpi.com/1422-0067/24/15/12441 |
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