A Review on the Crosstalk between Insulin and Wnt/β-Catenin Signalling for Bone Health

A Review on the Crosstalk between Insulin and Wnt/β-Catenin Signalling for Bone Health

A positive association between insulin resistance and osteoporosis has been widely established. However, crosstalk between the signalling molecules in insulin and Wingless (Wnt)/beta-(β-)catenin transduction cascades orchestrating bone homeostasis remains not well understood. The current review aims...

Full description

Bibliographic Details
Main Authors:	Sok Kuan Wong, Nur Vaizura Mohamad, Putri Ayu Jayusman, Nurul ‘Izzah Ibrahim
Format:	Article
Language:	English
Published:	MDPI AG 2023-08-01
Series:	International Journal of Molecular Sciences
Subjects:	bone loss glycogen synthase kinase-3 beta GSK3β type 1 diabetes mellitus type 2 diabetes mellitus
Online Access:	https://www.mdpi.com/1422-0067/24/15/12441

Similar Items

Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it’s role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. A mini-review
by: A. Ullah, et al.
Published: (2021-09-01)

GSK-3 protein and the heart: friend or foe?
by: B. Huisamen, et al.
Published: (2017-04-01)

Commentary: GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response
by: Andre De Souza, et al.
Published: (2020-10-01)

Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3β and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer’s Disease
by: Rohith N Thota, et al.
Published: (2020-04-01)

Increase in Subcellular GSK-3 Clusters in Insulin- and Adrenaline-treated Differentiated Rat Skeletal Muscle Fibres
by: Katja Fink, et al.
Published: (2020-04-01)

Swimming training alleviated insulin resistance through Wnt3a/β-catenin signaling in type 2 diabetic rats
by: Qiang Yang, et al.
Published: (2017-11-01)

Glycogen synthase kinase 3 (GSK-3) and its inhibitors : drug discovery and development /
by: Martinez, Ana, 1961-, et al.
Published: (2006)

Clinical activity of 9-ING-41, a small molecule selective glycogen synthase kinase-3 beta (GSK-3β) inhibitor, in refractory adult T-Cell leukemia/lymphoma
by: Andrew Hsu, et al.
Published: (2022-12-01)

When You Come to a Fork in the Road, Take It: Wnt Signaling Activates Multiple Pathways through the APC/Axin/GSK-3 Complex
by: Chenchen Li, et al.
Published: (2023-09-01)

TEST-SYSTEM FOR ESTIMATION OF ACTIVITY OF GSK-3 INHIBITORS AS ANTIHYPOXANTS AND DIFFERENTIATION OF ENDOTHELIAL PROGENITORS IN VITRO
by: Youri Burda, et al.
Published: (2016-03-01)

GSK3β Inhibition Reduced Vascular Calcification in <i>Ins2<sup>Akita/+</sup></i> Mice
by: Kristina I. Boström, et al.
Published: (2023-03-01)

Intermittent Fasting Modulates the Glycogen Level in Zebrafish (Danio rerio) and their Next Generation
by: ShanmugaSundaram Tamilarasan, et al.
Published: (2022-12-01)

The Effect of Decreased Activity in the Form of Neuropathic Pain on GSK-3β Gene Expression in Sciatic Nerve Fiber of Male Wistar Rats
by: Masoud Rahmati, et al.
Published: (2018-04-01)

Association of glycogen synthase kinase-3β with cognitive impairment in type 2 diabetes patients: a six-year follow-up study
by: Wei Wei, et al.
Published: (2024-04-01)

Akt signaling pathway: a potential therapy for Alzheimer’s disease through glycogen synthase kinase 3 beta inhibition
by: Joshua Limantoro, et al.
Published: (2023-11-01)

Brassinazole Resistant 1 Activity Is Organ-Specific and Genotype-Dependent in Barley Seedlings
by: Jolanta Groszyk, et al.
Published: (2021-12-01)

Regulatory network of GSK3-like kinases and their role in plant stress response
by: Yun Song, et al.
Published: (2023-03-01)

Glycogen synthase kinase-3: A promising therapeutic target for Fragile X Syndrome
by: Marjelo M. Mines, et al.
Published: (2011-11-01)

Insulin directly stimulates mitochondrial glucose oxidation in the heart
by: Qutuba G. Karwi, et al.
Published: (2020-12-01)

Periphery Biomarkers for Objective Diagnosis of Cognitive Decline in Type 2 Diabetes Patients
by: Yanchao Liu, et al.
Published: (2021-10-01)

Three cases of glycogenic hepatopathy mimicking acute and relapsing hepatitis in type I diabetes mellitus
by: Jae Hwang Cha, et al.
Published: (2013-12-01)

Glycogenic hepatopathy in a Korean girl with poorly controlled type 1 diabetes mellitus
by: Hwal Rim Jeong, et al.
Published: (2014-03-01)

Microdose Lithium Protects against Pancreatic Islet Destruction and Renal Impairment in Streptozotocin-Elicited Diabetes
by: Jiahui Zhang, et al.
Published: (2021-01-01)

Novel GYS2 mutations in a Japanese patient with glycogen storage disease type 0a
by: Hiroyuki Iijima, et al.
Published: (2021-03-01)

Effects of GSK-3 inhibition on LPS-induced neuroinflammation and IL-10 production in microglia
by: Md Zain, Zuhaida
Published: (2016)

Yeast Glycogen Synthase Kinase-3 Pathway Inhibitors from an Organic Extract of Streptomyces sp.
by: Cheenpracha, Sarot, et al.
Published: (2009)

Integrating Machine Learning-Based Virtual Screening With Multiple Protein Structures and Bio-Assay Evaluation for Discovery of Novel GSK3β Inhibitors
by: Jingyu Zhu, et al.
Published: (2020-09-01)

Biomarkers for Early Diagnostic of Mild Cognitive Impairment in Type-2 Diabetes Patients: A Multicentre, Retrospective, Nested Case–Control Study
by: Zhi-Peng Xu, et al.
Published: (2016-03-01)

Creatine Kinase Activity in Patients with Diabetes Mellitus Type I and Type II
by: Adlija Jevrić-Čaušević, et al.
Published: (2006-08-01)

Macrophage Function and the Role of GSK3
by: Sarvatit Patel, et al.
Published: (2021-02-01)

Fluoride as a Potential Repressor of Glycogen Metabolism in Skeletal Muscle Cell Line CCL136
by: Izabela Gutowska, et al.
Published: (2023-08-01)

Celebrating 100 Years of Insulin Use
by: Zrinka Šakić, et al.
Published: (2022-01-01)

Effects of Lithium on Morphine Tolerance Using Analgesia, Nitrite Determination, Histology and Immunohistochemistry of Forehead Cortex in Adult Male Swiss Mice
by: Saman Barzegar, et al.
Published: (2022-09-01)

Antidiabetic Drugs in the Treatment of Alzheimer’s Disease
by: Michalis Michailidis, et al.
Published: (2022-04-01)

Hydroxy-α-sanshool isolated from Zanthoxylum bungeanum Maxim. has antidiabetic effects on high-fat-fed and streptozotocin-treated mice via increasing glycogen synthesis by regulation of PI3K/Akt/GSK-3β/GS signaling
by: Qing Zhang, et al.
Published: (2022-12-01)

4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone Inhibits MCPyV T Antigen Expression in Merkel Cell Carcinoma Independent of Aurora Kinase A
by: Roland Houben, et al.
Published: (2023-04-01)

Additional Inhibition of Wnt/β-Catenin Signaling by Metformin in DAA Treatments as a Novel Therapeutic Strategy for HCV-Infected Patients
by: Dong Lin, et al.
Published: (2021-04-01)

Deletion of Macrophage-Specific Glycogen Synthase Kinase (GSK)-3α Promotes Atherosclerotic Regression in <i>Ldlr</i><sup>−/−</sup> Mice
by: Sarvatit Patel, et al.
Published: (2022-08-01)

Inhibitory Effect of 1,8-Cineol on β-Catenin Regulation, WNT11 Expression, and Cellular Progression in HNSCC
by: Anna Roettger, et al.
Published: (2017-05-01)

Effect of Xenon on the Phosphorylation of Glycogen Synthase Kinase 3β and Antioxidant Enzymes in Rat Brain
by: A. N. Kuzovlev, et al.
Published: (2021-01-01)