Medication adherence and cognitive performance in schizophrenia-spectrum and bipolar disorder: results from the PsyCourse Study
Abstract Existing guidelines recommend psychopharmacological treatment for the management of schizophrenia and bipolar disorder as part of holistic treatment concepts. About half of the patients do not take their medication regularly, although treatment adherence can prevent exacerbations and re-hos...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-03-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-023-02373-x |
| _version_ | 1797859861666463744 |
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| author | Fanny Senner Lena Hiendl Susanne Bengesser Kristina Adorjan Ion-George Anghelescu Bernhardt T. Baune Monika Budde Udo Dannlowski Detlef E. Dietrich Peter Falkai Andreas J. Fallgatter Alkomiet Hasan Maria Heilbronner Markus Jäger Georg Juckel Janos L. Kalman Carsten Konrad Mojtaba Oraki Kohshour Sergi Papiol Daniela Reich-Erkelenz Jens Reimer Sabrina K. Schaupp Max Schmauß Simon Senner Carsten Spitzer Thomas Vogl Jörg Zimmermann Urs Heilbronner Eva C. Schulte Thomas G. Schulze Eva Z. Reininghaus Sophie-Kathrin Kirchner Nina Dalkner |
| author_facet | Fanny Senner Lena Hiendl Susanne Bengesser Kristina Adorjan Ion-George Anghelescu Bernhardt T. Baune Monika Budde Udo Dannlowski Detlef E. Dietrich Peter Falkai Andreas J. Fallgatter Alkomiet Hasan Maria Heilbronner Markus Jäger Georg Juckel Janos L. Kalman Carsten Konrad Mojtaba Oraki Kohshour Sergi Papiol Daniela Reich-Erkelenz Jens Reimer Sabrina K. Schaupp Max Schmauß Simon Senner Carsten Spitzer Thomas Vogl Jörg Zimmermann Urs Heilbronner Eva C. Schulte Thomas G. Schulze Eva Z. Reininghaus Sophie-Kathrin Kirchner Nina Dalkner |
| author_sort | Fanny Senner |
| collection | DOAJ |
| description | Abstract Existing guidelines recommend psychopharmacological treatment for the management of schizophrenia and bipolar disorder as part of holistic treatment concepts. About half of the patients do not take their medication regularly, although treatment adherence can prevent exacerbations and re-hospitalizations. To date, the relationship between medication adherence and cognitive performance is understudied. Therefore, this study investigated the relationship between medication adherence and cognitive performance by analyzing the data of 862 participants with schizophrenia-spectrum and bipolar disorders (mean [SD] age, 41.9 [12.48] years; 44.8% female) from a multicenter study (PsyCourse Study). Z-scores for three cognitive domains were calculated, global functioning was measured with the Global Assessment of Functioning Scale, and adherence was assessed by a self-rating questionnaire. We evaluated four multiple linear regression models and built three clusters with hierarchical cluster analyses. Higher adherence behavior (p < 0.001) was associated with better global functioning but showed no impact on the cognitive domains learning and memory, executive function, and psychomotor speed. The hierarchical cluster analysis resulted in three clusters with different cognitive performances, but patients in all clusters showed similar adherence behavior. The study identified cognitive subgroups independent of diagnoses, but no differences were found in the adherence behavior of the patients in these new clusters. In summary, medication adherence was associated with global but not cognitive functioning in patients with schizophrenia-spectrum and bipolar disorders. In both diagnostic groups, cognitive function might be influenced by various factors but not medication adherence. |
| first_indexed | 2024-04-09T21:36:25Z |
| format | Article |
| id | doaj.art-fed399fc8cce403092c3ddc282f7c12f |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-04-09T21:36:25Z |
| publishDate | 2023-03-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-fed399fc8cce403092c3ddc282f7c12f2023-03-26T11:18:16ZengNature Publishing GroupTranslational Psychiatry2158-31882023-03-0113111010.1038/s41398-023-02373-xMedication adherence and cognitive performance in schizophrenia-spectrum and bipolar disorder: results from the PsyCourse StudyFanny Senner0Lena Hiendl1Susanne Bengesser2Kristina Adorjan3Ion-George Anghelescu4Bernhardt T. Baune5Monika Budde6Udo Dannlowski7Detlef E. Dietrich8Peter Falkai9Andreas J. Fallgatter10Alkomiet Hasan11Maria Heilbronner12Markus Jäger13Georg Juckel14Janos L. Kalman15Carsten Konrad16Mojtaba Oraki Kohshour17Sergi Papiol18Daniela Reich-Erkelenz19Jens Reimer20Sabrina K. Schaupp21Max Schmauß22Simon Senner23Carsten Spitzer24Thomas Vogl25Jörg Zimmermann26Urs Heilbronner27Eva C. Schulte28Thomas G. Schulze29Eva Z. Reininghaus30Sophie-Kathrin Kirchner31Nina Dalkner32Department of Psychiatry and Psychotherapy, University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Neurobiology and Anthropometrics in Bipolar Affective Disorder, Medical University of GrazDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Neurobiology and Anthropometrics in Bipolar Affective Disorder, Medical University of GrazDepartment of Psychiatry and Psychotherapy, University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, Mental Health Institute BerlinDepartment of Psychiatry, University of MünsterInstitute of Psychiatric Phenomics and Genomics, University Hospital, LMU MunichInstitute for Translational Psychiatry, University of MünsterAMEOS Clinical Center HildesheimDepartment of Psychiatry and Psychotherapy, University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of TübingenDepartment of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, University of Augsburg, Bezirkskrankenhaus AugsburgInstitute of Psychiatric Phenomics and Genomics, University Hospital, LMU MunichDepartment of Psychiatry II, Ulm University, Bezirkskrankenhaus GünzburgDepartment of Psychiatry, Ruhr University Bochum, LWL University HospitalDepartment of Psychiatry and Psychotherapy, University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, Agaplesion DiakonieklinikumInstitute of Psychiatric Phenomics and Genomics, University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, University Hospital, LMU MunichInstitute of Psychiatric Phenomics and Genomics, University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-EppendorfInstitute of Psychiatric Phenomics and Genomics, University Hospital, LMU MunichDepartment of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, University of Augsburg, Bezirkskrankenhaus AugsburgCenter for Psychiatry Reichenau, Academic Hospital University of KonstanzDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center RostockInstitute of Psychiatric Phenomics and Genomics, University Hospital, LMU MunichPsychiatrieverbund Oldenburger Land gGmbH, Karl-Jaspers-KlinikInstitute of Psychiatric Phenomics and Genomics, University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapy, University Hospital, LMU MunichInstitute of Psychiatric Phenomics and Genomics, University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Neurobiology and Anthropometrics in Bipolar Affective Disorder, Medical University of GrazDepartment of Psychiatry and Psychotherapy, University Hospital, LMU MunichDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for Neurobiology and Anthropometrics in Bipolar Affective Disorder, Medical University of GrazAbstract Existing guidelines recommend psychopharmacological treatment for the management of schizophrenia and bipolar disorder as part of holistic treatment concepts. About half of the patients do not take their medication regularly, although treatment adherence can prevent exacerbations and re-hospitalizations. To date, the relationship between medication adherence and cognitive performance is understudied. Therefore, this study investigated the relationship between medication adherence and cognitive performance by analyzing the data of 862 participants with schizophrenia-spectrum and bipolar disorders (mean [SD] age, 41.9 [12.48] years; 44.8% female) from a multicenter study (PsyCourse Study). Z-scores for three cognitive domains were calculated, global functioning was measured with the Global Assessment of Functioning Scale, and adherence was assessed by a self-rating questionnaire. We evaluated four multiple linear regression models and built three clusters with hierarchical cluster analyses. Higher adherence behavior (p < 0.001) was associated with better global functioning but showed no impact on the cognitive domains learning and memory, executive function, and psychomotor speed. The hierarchical cluster analysis resulted in three clusters with different cognitive performances, but patients in all clusters showed similar adherence behavior. The study identified cognitive subgroups independent of diagnoses, but no differences were found in the adherence behavior of the patients in these new clusters. In summary, medication adherence was associated with global but not cognitive functioning in patients with schizophrenia-spectrum and bipolar disorders. In both diagnostic groups, cognitive function might be influenced by various factors but not medication adherence.https://doi.org/10.1038/s41398-023-02373-x |
| spellingShingle | Fanny Senner Lena Hiendl Susanne Bengesser Kristina Adorjan Ion-George Anghelescu Bernhardt T. Baune Monika Budde Udo Dannlowski Detlef E. Dietrich Peter Falkai Andreas J. Fallgatter Alkomiet Hasan Maria Heilbronner Markus Jäger Georg Juckel Janos L. Kalman Carsten Konrad Mojtaba Oraki Kohshour Sergi Papiol Daniela Reich-Erkelenz Jens Reimer Sabrina K. Schaupp Max Schmauß Simon Senner Carsten Spitzer Thomas Vogl Jörg Zimmermann Urs Heilbronner Eva C. Schulte Thomas G. Schulze Eva Z. Reininghaus Sophie-Kathrin Kirchner Nina Dalkner Medication adherence and cognitive performance in schizophrenia-spectrum and bipolar disorder: results from the PsyCourse Study Translational Psychiatry |
| title | Medication adherence and cognitive performance in schizophrenia-spectrum and bipolar disorder: results from the PsyCourse Study |
| title_full | Medication adherence and cognitive performance in schizophrenia-spectrum and bipolar disorder: results from the PsyCourse Study |
| title_fullStr | Medication adherence and cognitive performance in schizophrenia-spectrum and bipolar disorder: results from the PsyCourse Study |
| title_full_unstemmed | Medication adherence and cognitive performance in schizophrenia-spectrum and bipolar disorder: results from the PsyCourse Study |
| title_short | Medication adherence and cognitive performance in schizophrenia-spectrum and bipolar disorder: results from the PsyCourse Study |
| title_sort | medication adherence and cognitive performance in schizophrenia spectrum and bipolar disorder results from the psycourse study |
| url | https://doi.org/10.1038/s41398-023-02373-x |
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