Miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis in Brazil: a randomized and controlled trial.

Miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis in Brazil: a randomized and controlled trial.

<h4>Background</h4>Cutaneous leishmaniasis (CL) is treated with parenteral drugs for decades with decreasing rate cures. Miltefosine is an oral medication with anti-leishmania activity and may increase the cure rates and improve compliance.<h4>Methodology/principal findings</h4&...

Full description

Bibliographic Details
Main Authors:	Paulo R Machado, Julia Ampuero, Luiz H Guimarães, Leonardo Villasboas, Ana T Rocha, Albert Schriefer, Rosana S Sousa, Anette Talhari, Gerson Penna, Edgar M Carvalho
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2010-12-01
Series:	PLoS Neglected Tropical Diseases
Online Access:	https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0000912&type=printable

Similar Items

Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects.
by: Luiz Henrique Guimarães, et al.
Published: (2016-12-01)

The Influence of Infection by Different Leishmania (Viannia) braziliensis Isolates on the Pathogenesis of Disseminated Leishmaniasis
by: Walker N. Oliveira, et al.
Published: (2021-09-01)

Early Suppression of Macrophage Gene Expression by Leishmania braziliensis
by: Rosana Sousa, et al.
Published: (2018-10-01)

Investigation of the pathways related to intrinsic miltefosine tolerance in Leishmania (Viannia) braziliensis clinical isolates reveals differences in drug uptake
by: Caroline R. Espada, et al.
Published: (2019-12-01)

Characterization of Neutrophil Function in Human Cutaneous Leishmaniasis Caused by Leishmania braziliensis.
by: Jacilara Conceição, et al.
Published: (2016-05-01)

Disseminated cutaneous leishmaniasis caused by Leishmania braziliensis in Southern Brazil
by: Norberto Assis Membrive, et al.

Outbreak of Leishmania braziliensis Cutaneous Leishmaniasis, Saül, French Guiana
by: Guillaume Martin-Blondel, et al.
Published: (2015-05-01)

Experimental canine mucocutaneous leishmaniasis (Leishmania braziliensis braziliensis)
by: Claude Pirmez, et al.
Published: (1988-06-01)

Canine cutaneous leishmaniasis by Leishmania (Viannia) braziliensis in an agricultural settlement, endemic area for leishmaniasis
by: A.F. Brilhante, et al.
Published: (2016-08-01)

Dynamics of American tegumentary leishmaniasis in a highly endemic region for Leishmania (Viannia) braziliensis infection in northeast Brazil.
by: Juliana Silva, et al.
Published: (2017-11-01)

Clinical and histopathologic features of canine tegumentary leishmaniasis and the molecular characterization of Leishmania braziliensis in dogs.
by: Jamile Lago, et al.
Published: (2019-07-01)

Evaluation of the Ability of Miltefosine Associated with Topical GM-CSF in Modulating the Immune Response of Patients with Cutaneous Leishmaniasis
by: Fábio Peixoto, et al.
Published: (2020-01-01)

Inefficacy of the association N-methyl glucamine and topical miltefosine in the treatment of experimental cutaneous leishmaniasis by Leishmania (Leishmania) amazonensis
by: R. N. R. Sampaio, et al.
Published: (2007-01-01)

Cutaneous leishmaniasis caused by members of Leishmania braziliensis complex in Nayarit, State of Mexico
by: Gustavo Sanchez-Tejeda, et al.
Published: (2001-01-01)

Safety profile of miltefosine in the treatment of cutaneous leishmaniasis.
by: Laís Raquel Ribeiro, et al.
Published: (2024-01-01)

Tolerability and Safety of Miltefosine for the Treatment of Cutaneous Leishmaniasis
by: Nadav Astman, et al.
Published: (2024-09-01)

Pentavalent Antimony Associated with G-CSF in the Treatment of Cutaneous Leishmaniasis Caused by <i>Leishmania (Viannia) braziliensis</i>
by: Carvel Suprien, et al.
Published: (2024-04-01)

Differential effects of antigens from <it>L. braziliensis </it>isolates from disseminated and cutaneous leishmaniasis on <it>in vitro </it>cytokine production
by: Guimarães Luiz, et al.
Published: (2006-04-01)

Disseminated Leishmaniasis, a Severe Form of Leishmania Braziliensis Infection
by: Paulo R.L. Machado, et al.
Published: (2024-03-01)

Sensitivity of Lymph Node Aspiration in Localized Cutaneous Leishmaniasis Due to Leishmania (Viannia) braziliensis
by: Romero Gustavo Adolfo Sierra, et al.
Published: (1999-01-01)

Leishmania (Viannia) braziliensis is the main species causing cutaneous leishmaniasis in the Federal District of Brazil
by: GM Santos, et al.
Published: (2012-01-01)

Chemotherapeutic potential of 17-AAG against cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis.
by: Diego M Santos, et al.
Published: (2014-10-01)

Complex cutaneous infection by Leishmania mexicana treated with miltefosine
by: Rachel L. Sadowsky, BA, et al.
Published: (2022-11-01)

Anti-Leishmania IgG is a marker of disseminated leishmaniasis caused by Leishmania braziliensis
by: Andréa Magalhães, et al.
Published: (2021-05-01)

Use of miltefosine in the treatment of cutaneous leishmaniasis in French Guiana
by: Charlene Oliveira, et al.
Published: (2024-07-01)

Investigation of in vitro Efficacy of Miltefosine on Chronic Cutaneous Leishmaniasis
by: Varol Tunalı, et al.
Published: (2022-06-01)

Xenodiagnostico con Lutzomyia youngi en casos venezolanos de leishmaniasis cutaned por Leishmania braziliensis Xenodiagnosis with Lutzomyia youngi in Venezuelan cases of cutaneous leishmaniais due to Leishmania braziliensis
by: Elina Rojas, et al.
Published: (1989-03-01)

The Role of Nitric Oxide and Reactive Oxygen Species in the Killing of Leishmania braziliensis by Monocytes from Patients with Cutaneous Leishmaniasis.
by: Pedro Paulo Carneiro, et al.
Published: (2016-01-01)

Canine Cutaneous Leishmaniasis: Dissemination and Tissue Tropism of Genetically Distinct Leishmania (Viannia) braziliensis Populations
by: Guilherme Marx de Oliveira, et al.
Published: (2013-01-01)

A dysflagellar mutant of <it>Leishmania (Viannia) braziliensis </it>isolated from a cutaneous leishmaniasis patient
by: Zauli Rogéria C, et al.
Published: (2012-01-01)

In vitro and in vivo miltefosine susceptibility of a Leishmania amazonensis isolate from a patient with diffuse cutaneous leishmaniasis.
by: Adriano C Coelho, et al.
Published: (2014-07-01)

Human mucocutaneous leishmaniasis in Três Braços, Bahia - Brazil: an area of Leishmania braziliensis braziliensis transmission. II. Cutaneous disease. Presentation and evolution
by: Elmer A. Llanos-Cuentas, et al.
Published: (1984-12-01)

Human mucocutaneous leishmaniasis in Três Braços, Bahia - Brazil: an area of Leishmania braziliensis braziliensis transmission. II. Cutaneous disease. Presentation and evolution
by: Elmer A. Llanos-Cuentas, et al.
Published: (1984-12-01)

Leishmania (Viannia) braziliensis type 2 as probable etiological agent of canine cutaneous leishmaniasis in Brazilian Amazon.
by: Andreia Fernandes Brilhante, et al.
Published: (2019-01-01)

Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl/6 mice
by: Ana Angélica Amorim Santarem, et al.
Published: (2014-07-01)

Comparing the Effects of Topical Miltefosine and Glucantime in Treatment of Cutaneous Leishmaniasis
by: Ali Asilian, et al.
Published: (2014-03-01)

Dynamics of parasite clearance in cutaneous leishmaniasis patients treated with miltefosine.
by: Thomas P C Dorlo, et al.
Published: (2011-12-01)

Cutaneous Leishmaniasis in Venezuela Caused by Infection with a New Hybrid between Leishmania (Viannia) braziliensis and L. (V.) guyanensis
by: Delgado Olinda, et al.
Published: (1997-01-01)

Ecoepidemiology of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis in the Atlantic rain forest region of Pernambuco, Brazil
by: Sinval Pinto BRANDÃO FILHO
Published: (2001-06-01)

GENOTYPE CHARACTERIZATION OF Leishmania (Viannia) braziliensis ISOLATED FROM HUMAN AND CANINE BIOPSIES WITH AMERICAN CUTANEOUS LEISHMANIASIS
by: Lasaro Teixeira FERREIRA, et al.
Published: (2015-06-01)