Epigallocatechin-3-Gallate (EGCG)-Inducible SMILE Inhibits STAT3-Mediated Hepcidin Gene Expression

Epigallocatechin-3-Gallate (EGCG)-Inducible SMILE Inhibits STAT3-Mediated Hepcidin Gene Expression

Hepatic peptide hormone hepcidin, a key regulator of iron metabolism, is induced by inflammatory cytokine interleukin-6 (IL-6) in the pathogenesis of anemia of inflammation or microbial infections. Small heterodimer partner-interacting leucine zipper protein (SMILE)/CREBZF is a transcriptional corep...

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Bibliographic Details
Main Authors: Yu-Ji Kim, Ki-Sun Kim, Daejin Lim, Dong Ju Yang, Jae-Il Park, Ki Woo Kim, Jae-Ho Jeong, Hueng-Sik Choi, Don-Kyu Kim
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Antioxidants
Subjects:
epigallocatechin-3-gallate
SMILE
IL-6
STAT3
FoxO1
hepcidin
Online Access:https://www.mdpi.com/2076-3921/9/6/514

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