Potential Benefits of Combined Statin and Metformin Therapy on Resistance Training Response in Older Individuals
Metformin and statins are currently the focus of large clinical trials testing their ability to counter age-associated declines in health, but recent reports suggest that both may negatively affect skeletal muscle response to exercise. However, it has also been suggested that metformin may act as a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.872745/full |
| _version_ | 1828349893380407296 |
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| author | Douglas E. Long Kate Kosmac Cory M. Dungan Marcas M. Bamman Marcas M. Bamman Charlotte A. Peterson Philip A. Kern |
| author_facet | Douglas E. Long Kate Kosmac Cory M. Dungan Marcas M. Bamman Marcas M. Bamman Charlotte A. Peterson Philip A. Kern |
| author_sort | Douglas E. Long |
| collection | DOAJ |
| description | Metformin and statins are currently the focus of large clinical trials testing their ability to counter age-associated declines in health, but recent reports suggest that both may negatively affect skeletal muscle response to exercise. However, it has also been suggested that metformin may act as a possible protectant of statin-related muscle symptoms. The potential impact of combined drug use on the hypertrophic response to resistance exercise in healthy older adults has not been described. We present secondary statin analyses of data from the MASTERS trial where metformin blunted the hypertrophy response in healthy participants (>65 years) following 14 weeks of progressive resistance training (PRT) when compared to identical placebo treatment (n = 94). Approximately one-third of MASTERS participants were taking prescribed statins. Combined metformin and statin resulted in rescue of the metformin-mediated impaired growth response to PRT but did not significantly affect strength. Improved muscle fiber growth may be associated with medication-induced increased abundance of CD11b+/CD206+ M2-like macrophages. Sarcopenia is a significant problem with aging and this study identifies a potential interaction between these commonly used drugs which may help prevent metformin-related blunting of the beneficial effects of PRT.Trial Registration: ClinicalTrials.gov, NCT02308228, Registered on 25 November 2014. |
| first_indexed | 2024-04-14T01:17:25Z |
| format | Article |
| id | doaj.art-fed91fc4403a44c8b93878421c3c949c |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-14T01:17:25Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-fed91fc4403a44c8b93878421c3c949c2022-12-22T02:20:49ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-04-011310.3389/fphys.2022.872745872745Potential Benefits of Combined Statin and Metformin Therapy on Resistance Training Response in Older IndividualsDouglas E. Long0Kate Kosmac1Cory M. Dungan2Marcas M. Bamman3Marcas M. Bamman4Charlotte A. Peterson5Philip A. Kern6Department of Physical Therapy and Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, United StatesDepartment of Physical Therapy and Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, United StatesDepartment of Physical Therapy and Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, United StatesFlorida Institute for Human and Machine Cognition, Pensacola, FL, United StatesCenter for Exercise Medicine and Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, United StatesDepartment of Physical Therapy and Center for Muscle Biology, College of Health Sciences, University of Kentucky, Lexington, KY, United StatesDepartment of Internal Medicine, Division of Endocrinology, Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY, United StatesMetformin and statins are currently the focus of large clinical trials testing their ability to counter age-associated declines in health, but recent reports suggest that both may negatively affect skeletal muscle response to exercise. However, it has also been suggested that metformin may act as a possible protectant of statin-related muscle symptoms. The potential impact of combined drug use on the hypertrophic response to resistance exercise in healthy older adults has not been described. We present secondary statin analyses of data from the MASTERS trial where metformin blunted the hypertrophy response in healthy participants (>65 years) following 14 weeks of progressive resistance training (PRT) when compared to identical placebo treatment (n = 94). Approximately one-third of MASTERS participants were taking prescribed statins. Combined metformin and statin resulted in rescue of the metformin-mediated impaired growth response to PRT but did not significantly affect strength. Improved muscle fiber growth may be associated with medication-induced increased abundance of CD11b+/CD206+ M2-like macrophages. Sarcopenia is a significant problem with aging and this study identifies a potential interaction between these commonly used drugs which may help prevent metformin-related blunting of the beneficial effects of PRT.Trial Registration: ClinicalTrials.gov, NCT02308228, Registered on 25 November 2014.https://www.frontiersin.org/articles/10.3389/fphys.2022.872745/fullstatinmetforminmuscle hypertrophycellular featuresresistance training |
| spellingShingle | Douglas E. Long Kate Kosmac Cory M. Dungan Marcas M. Bamman Marcas M. Bamman Charlotte A. Peterson Philip A. Kern Potential Benefits of Combined Statin and Metformin Therapy on Resistance Training Response in Older Individuals Frontiers in Physiology statin metformin muscle hypertrophy cellular features resistance training |
| title | Potential Benefits of Combined Statin and Metformin Therapy on Resistance Training Response in Older Individuals |
| title_full | Potential Benefits of Combined Statin and Metformin Therapy on Resistance Training Response in Older Individuals |
| title_fullStr | Potential Benefits of Combined Statin and Metformin Therapy on Resistance Training Response in Older Individuals |
| title_full_unstemmed | Potential Benefits of Combined Statin and Metformin Therapy on Resistance Training Response in Older Individuals |
| title_short | Potential Benefits of Combined Statin and Metformin Therapy on Resistance Training Response in Older Individuals |
| title_sort | potential benefits of combined statin and metformin therapy on resistance training response in older individuals |
| topic | statin metformin muscle hypertrophy cellular features resistance training |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.872745/full |
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