Causal association between thyroid dysfunction and sepsis: a two-sample mendelian randomization study
BackgroundThe causal association between thyroid dysfunction (including hyperthyroidism and hypothyroidism) and sepsis is controversial in previous studies. Therefore, we used Mendelian randomization (MR) to explore the causal association between hyperthyroidism or hypothyroidism and the susceptibil...
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| Format: | Article |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1348248/full |
| _version_ | 1827311966095409152 |
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| author | Junbin Hong Lian Zhang Yanni Lai Xinying Chen Xinying Chen Yiting Chen Yiting Chen Jinghua Yang Jinghua Yang |
| author_facet | Junbin Hong Lian Zhang Yanni Lai Xinying Chen Xinying Chen Yiting Chen Yiting Chen Jinghua Yang Jinghua Yang |
| author_sort | Junbin Hong |
| collection | DOAJ |
| description | BackgroundThe causal association between thyroid dysfunction (including hyperthyroidism and hypothyroidism) and sepsis is controversial in previous studies. Therefore, we used Mendelian randomization (MR) to explore the causal association between hyperthyroidism or hypothyroidism and the susceptibility to four distinct subtypes of sepsis (streptococcal sepsis, puerperal sepsis, asthma-associated pneumonia or sepsis, and other sepsis).MethodsIn our research, we conducted two-sample Mendelian randomization (MR) analyses utilizing publicly available genome-wide association studies (GWAS) data from Sakaue et al. and the Finnish database to investigate the potential causal associations between hyperthyroidism, hypothyroidism, and each of the four distinct subtypes of sepsis, in addition to reverse MR analyses of the positive results to examine the existence of reverse causality.ResultsGenetic hypothyroidism was causally related to the development of asthma-associated pneumonia or sepsis (ORIVW: 1.097, 95% CI: 1.024 to 1.174, P = 0.008); hypothyroidism was significantly associated with the development of other sepsis (ORIVW: 1.070, 95% CI: 1.028 to 1.115, P < 0.001). In addition, sensitivity analysis substantiated the robustness of these two MR findings, with no evidence of horizontal pleiotropy observed (P > 0.05). MR Egger regression analysis demonstrated no heterogeneity between instrumental variables (IVs). Inverse MR results confirmed no reverse causality between hypothyroidism and asthma-associated pneumonia or sepsis, or between hypothyroidism and other sepsis. The findings of this study also unveiled that there is no evidence of a causal link between hypothyroidism and the development of streptococcal sepsis or puerperal sepsis. Additionally, the research provided evidence indicating the absence of a causal relationship between hyperthyroidism and streptococcal sepsis, puerperal sepsis, asthma-associated pneumonia or sepsis, and other sepsis.ConclusionsThis study identified a causal link between hypothyroidism and the occurrence of asthma-associated pneumonia or sepsis, and other sepsis, but not with the development of streptococcal sepsis and puerperal sepsis. Moreover, our findings did not reveal any causal association between hyperthyroidism and streptococcal sepsis, puerperal sepsis, asthma-associated pneumonia or sepsis, and other sepsis. |
| first_indexed | 2024-04-24T20:28:37Z |
| format | Article |
| id | doaj.art-feda852c5906407e969b67f98581f45b |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-24T20:28:37Z |
| publishDate | 2024-03-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-feda852c5906407e969b67f98581f45b2024-03-22T04:34:22ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-03-011510.3389/fendo.2024.13482481348248Causal association between thyroid dysfunction and sepsis: a two-sample mendelian randomization studyJunbin Hong0Lian Zhang1Yanni Lai2Xinying Chen3Xinying Chen4Yiting Chen5Yiting Chen6Jinghua Yang7Jinghua Yang8The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, ChinaSchool of Medicine and Health, Shunde Polytechnic, Foshan, ChinaDepartment of Pediatrics, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, ChinaXiaorong Luo’s National Renowned Expert Inheritance Studio, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaDepartment of Pediatrics, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, ChinaXiaorong Luo’s National Renowned Expert Inheritance Studio, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaDepartment of Pediatrics, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, ChinaXiaorong Luo’s National Renowned Expert Inheritance Studio, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaBackgroundThe causal association between thyroid dysfunction (including hyperthyroidism and hypothyroidism) and sepsis is controversial in previous studies. Therefore, we used Mendelian randomization (MR) to explore the causal association between hyperthyroidism or hypothyroidism and the susceptibility to four distinct subtypes of sepsis (streptococcal sepsis, puerperal sepsis, asthma-associated pneumonia or sepsis, and other sepsis).MethodsIn our research, we conducted two-sample Mendelian randomization (MR) analyses utilizing publicly available genome-wide association studies (GWAS) data from Sakaue et al. and the Finnish database to investigate the potential causal associations between hyperthyroidism, hypothyroidism, and each of the four distinct subtypes of sepsis, in addition to reverse MR analyses of the positive results to examine the existence of reverse causality.ResultsGenetic hypothyroidism was causally related to the development of asthma-associated pneumonia or sepsis (ORIVW: 1.097, 95% CI: 1.024 to 1.174, P = 0.008); hypothyroidism was significantly associated with the development of other sepsis (ORIVW: 1.070, 95% CI: 1.028 to 1.115, P < 0.001). In addition, sensitivity analysis substantiated the robustness of these two MR findings, with no evidence of horizontal pleiotropy observed (P > 0.05). MR Egger regression analysis demonstrated no heterogeneity between instrumental variables (IVs). Inverse MR results confirmed no reverse causality between hypothyroidism and asthma-associated pneumonia or sepsis, or between hypothyroidism and other sepsis. The findings of this study also unveiled that there is no evidence of a causal link between hypothyroidism and the development of streptococcal sepsis or puerperal sepsis. Additionally, the research provided evidence indicating the absence of a causal relationship between hyperthyroidism and streptococcal sepsis, puerperal sepsis, asthma-associated pneumonia or sepsis, and other sepsis.ConclusionsThis study identified a causal link between hypothyroidism and the occurrence of asthma-associated pneumonia or sepsis, and other sepsis, but not with the development of streptococcal sepsis and puerperal sepsis. Moreover, our findings did not reveal any causal association between hyperthyroidism and streptococcal sepsis, puerperal sepsis, asthma-associated pneumonia or sepsis, and other sepsis.https://www.frontiersin.org/articles/10.3389/fendo.2024.1348248/fullhyperthyroidismhypothyroidismmendelian randomizationsepsisthyroid dysfunction |
| spellingShingle | Junbin Hong Lian Zhang Yanni Lai Xinying Chen Xinying Chen Yiting Chen Yiting Chen Jinghua Yang Jinghua Yang Causal association between thyroid dysfunction and sepsis: a two-sample mendelian randomization study Frontiers in Endocrinology hyperthyroidism hypothyroidism mendelian randomization sepsis thyroid dysfunction |
| title | Causal association between thyroid dysfunction and sepsis: a two-sample mendelian randomization study |
| title_full | Causal association between thyroid dysfunction and sepsis: a two-sample mendelian randomization study |
| title_fullStr | Causal association between thyroid dysfunction and sepsis: a two-sample mendelian randomization study |
| title_full_unstemmed | Causal association between thyroid dysfunction and sepsis: a two-sample mendelian randomization study |
| title_short | Causal association between thyroid dysfunction and sepsis: a two-sample mendelian randomization study |
| title_sort | causal association between thyroid dysfunction and sepsis a two sample mendelian randomization study |
| topic | hyperthyroidism hypothyroidism mendelian randomization sepsis thyroid dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1348248/full |
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