Exopolysaccharide-mediated surface penetration as new virulence trait in Enterococcus faecalis
Enterococcus faecalis is a commensal bacterium that normally inhabits the gastrointestinal tract of humans. This non-motile microorganism can also cause lethal infections in other organs by penetrating and breaching the intestinal barrier. However, the precise molecular mechanisms enabling E. faecal...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Communicative & Integrative Biology |
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| Online Access: | http://dx.doi.org/10.1080/19420889.2019.1657373 |
| _version_ | 1819275628429443072 |
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| author | Yusibeska Ramos Diana K. Morales |
| author_facet | Yusibeska Ramos Diana K. Morales |
| author_sort | Yusibeska Ramos |
| collection | DOAJ |
| description | Enterococcus faecalis is a commensal bacterium that normally inhabits the gastrointestinal tract of humans. This non-motile microorganism can also cause lethal infections in other organs by penetrating and breaching the intestinal barrier. However, the precise molecular mechanisms enabling E. faecalis movement and translocation across epithelial barriers remain incompletely characterized. We recently reported that E. faecalis utilizes the RpiA-GlnA-EpaX metabolic axis to generate β-1,6-linked poly-N-acetylglucosamine (polyGlcNAc)-containing exopolymers that are necessary for its optimal migration into semisolid surfaces and efficient translocation through human epithelial cell monolayers. These findings provide new evidence indicating that non-motile bacterial pathogens can exploit carbohydrate metabolism to penetrate surfaces. Hence, targeting this process might represent a new strategy to more effectively control systemic infections by E. faecalis. |
| first_indexed | 2024-12-23T23:27:21Z |
| format | Article |
| id | doaj.art-fedafb7bb0cc444ea8b62e57d0cb8c20 |
| institution | Directory Open Access Journal |
| issn | 1942-0889 |
| language | English |
| last_indexed | 2024-12-23T23:27:21Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Communicative & Integrative Biology |
| spelling | doaj.art-fedafb7bb0cc444ea8b62e57d0cb8c202022-12-21T17:26:11ZengTaylor & Francis GroupCommunicative & Integrative Biology1942-08892019-01-0112114414710.1080/19420889.2019.16573731657373Exopolysaccharide-mediated surface penetration as new virulence trait in Enterococcus faecalisYusibeska Ramos0Diana K. Morales1Weill Cornell MedicineWeill Cornell MedicineEnterococcus faecalis is a commensal bacterium that normally inhabits the gastrointestinal tract of humans. This non-motile microorganism can also cause lethal infections in other organs by penetrating and breaching the intestinal barrier. However, the precise molecular mechanisms enabling E. faecalis movement and translocation across epithelial barriers remain incompletely characterized. We recently reported that E. faecalis utilizes the RpiA-GlnA-EpaX metabolic axis to generate β-1,6-linked poly-N-acetylglucosamine (polyGlcNAc)-containing exopolymers that are necessary for its optimal migration into semisolid surfaces and efficient translocation through human epithelial cell monolayers. These findings provide new evidence indicating that non-motile bacterial pathogens can exploit carbohydrate metabolism to penetrate surfaces. Hence, targeting this process might represent a new strategy to more effectively control systemic infections by E. faecalis.http://dx.doi.org/10.1080/19420889.2019.1657373enterococcus faecalispolyglcnac-containing exopolysaccharidessemisolid surfacesepithelial cell monolayers |
| spellingShingle | Yusibeska Ramos Diana K. Morales Exopolysaccharide-mediated surface penetration as new virulence trait in Enterococcus faecalis Communicative & Integrative Biology enterococcus faecalis polyglcnac-containing exopolysaccharides semisolid surfaces epithelial cell monolayers |
| title | Exopolysaccharide-mediated surface penetration as new virulence trait in Enterococcus faecalis |
| title_full | Exopolysaccharide-mediated surface penetration as new virulence trait in Enterococcus faecalis |
| title_fullStr | Exopolysaccharide-mediated surface penetration as new virulence trait in Enterococcus faecalis |
| title_full_unstemmed | Exopolysaccharide-mediated surface penetration as new virulence trait in Enterococcus faecalis |
| title_short | Exopolysaccharide-mediated surface penetration as new virulence trait in Enterococcus faecalis |
| title_sort | exopolysaccharide mediated surface penetration as new virulence trait in enterococcus faecalis |
| topic | enterococcus faecalis polyglcnac-containing exopolysaccharides semisolid surfaces epithelial cell monolayers |
| url | http://dx.doi.org/10.1080/19420889.2019.1657373 |
| work_keys_str_mv | AT yusibeskaramos exopolysaccharidemediatedsurfacepenetrationasnewvirulencetraitinenterococcusfaecalis AT dianakmorales exopolysaccharidemediatedsurfacepenetrationasnewvirulencetraitinenterococcusfaecalis |