| Summary: | Introduction: This study aimed to evaluate the changes
both in the systemic inflammation and in the mucociliary clearance following
smoking cessation, and their associations with smoking characteristics.Methods: A total of 30 cases admitted to Konya Training and
Research Hospital, University of Health Sciences, Department of Smoking
Cessation were recruited, and 27 of them completed the study. Tumor necrosis
factor alpha (TNF-α), interleukin (IL) -4, IL-6, IL-8, IL-10 and saccharin
transit time (STT) was measuredat the beginning and 2 months after smoking
cessation.Results: We found in this study that STT decreased significantly
in 2 months after cessation (p lt;0.001). In our study, we found that serum
TNF-α (p=0.035) and IL-8 (p=0.002) levels were decreased significantly at 2
months after quitting when compared with the basal levels. In our study, serum
IL-6 (p=0.132) and IL-10 (p=0.657) levels did not change significantly in the
2nd month of quitting, when compared to basal levels.Conclusion: In this study, two months after smoking cessation,
nasal mucosal clearance and systemic inflammatory response especially plasma
TNF- α and IL-8 levels were improved. We think that further studies with larger
sample size and longer follow-up will provide more detailed data about the
improvements in systemic inflammation.
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