Diagnosis and Management of Immunotherapy-related Liver Toxicity
Immune checkpoint inhibitors have revolutionized the treatment of cancer. With the increasing use of immunotherapy, clinicians have observed that immunotherapy is often related to a spectrum of adverse events. Liver toxicity is one of the most common and severe immune-related adverse events. It is v...
| Main Authors: | , |
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| Format: | Article |
| Language: | zho |
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2021-09-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2021-0138 |
| _version_ | 1818388742643122176 |
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| author | HUA Yuwei ZHAO Lin |
| author_facet | HUA Yuwei ZHAO Lin |
| author_sort | HUA Yuwei |
| collection | DOAJ |
| description | Immune checkpoint inhibitors have revolutionized the treatment of cancer. With the increasing use of immunotherapy, clinicians have observed that immunotherapy is often related to a spectrum of adverse events. Liver toxicity is one of the most common and severe immune-related adverse events. It is very important to increase awareness and outline a clear and detailed strategy of managing immune-related liver toxicity. Some guidelines have published systematic advice on the management of immune-related liver toxicity. However, there are controversial problems remaining, including the levels of liver toxicity, the minimal effective dosage of hormone, treatments for hormone-refractory patients, and immunotherapy re-challenge. Additional, finding predictors with high specificity and sensitivity is a pressing concern. |
| first_indexed | 2024-12-14T04:30:41Z |
| format | Article |
| id | doaj.art-fedbee7a61344b0c8c947a5280bf250b |
| institution | Directory Open Access Journal |
| issn | 1674-9081 |
| language | zho |
| last_indexed | 2024-12-14T04:30:41Z |
| publishDate | 2021-09-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj.art-fedbee7a61344b0c8c947a5280bf250b2022-12-21T23:17:05ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812021-09-0112579880610.12290/xhyxzz.2021-0138Diagnosis and Management of Immunotherapy-related Liver ToxicityHUA YuweiZHAO LinImmune checkpoint inhibitors have revolutionized the treatment of cancer. With the increasing use of immunotherapy, clinicians have observed that immunotherapy is often related to a spectrum of adverse events. Liver toxicity is one of the most common and severe immune-related adverse events. It is very important to increase awareness and outline a clear and detailed strategy of managing immune-related liver toxicity. Some guidelines have published systematic advice on the management of immune-related liver toxicity. However, there are controversial problems remaining, including the levels of liver toxicity, the minimal effective dosage of hormone, treatments for hormone-refractory patients, and immunotherapy re-challenge. Additional, finding predictors with high specificity and sensitivity is a pressing concern.https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2021-0138immunotherapy-related liver toxicityimmune checkpoint inhibitorsimmune-related adverse eventsprogrammed death-1cytotoxic t lymphocyte associated antigen-4 |
| spellingShingle | HUA Yuwei ZHAO Lin Diagnosis and Management of Immunotherapy-related Liver Toxicity Xiehe Yixue Zazhi immunotherapy-related liver toxicity immune checkpoint inhibitors immune-related adverse events programmed death-1 cytotoxic t lymphocyte associated antigen-4 |
| title | Diagnosis and Management of Immunotherapy-related Liver Toxicity |
| title_full | Diagnosis and Management of Immunotherapy-related Liver Toxicity |
| title_fullStr | Diagnosis and Management of Immunotherapy-related Liver Toxicity |
| title_full_unstemmed | Diagnosis and Management of Immunotherapy-related Liver Toxicity |
| title_short | Diagnosis and Management of Immunotherapy-related Liver Toxicity |
| title_sort | diagnosis and management of immunotherapy related liver toxicity |
| topic | immunotherapy-related liver toxicity immune checkpoint inhibitors immune-related adverse events programmed death-1 cytotoxic t lymphocyte associated antigen-4 |
| url | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2021-0138 |
| work_keys_str_mv | AT huayuwei diagnosisandmanagementofimmunotherapyrelatedlivertoxicity AT zhaolin diagnosisandmanagementofimmunotherapyrelatedlivertoxicity |