The Difference of Cholesterol, Platelet and Cortisol Levels in Patients Diagnosed with Chronic Heart Failure with Reduced Ejection Fraction Groups According to Neutrophil Count
<i>Background and Objectives</i>: It is known that neutrophils are involved in the pro-inflammatory processes and thus, can have a great impact on the pathophysiology of heart failure (HF). Moreover, hypercholesterolemia heightens neutrophil production, thereby accelerating cardiovascula...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/6/557 |
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| author | Aušra Mongirdienė Jolanta Laukaitienė Vilius Skipskis Lolita Kuršvietienė Julius Liobikas |
| author_facet | Aušra Mongirdienė Jolanta Laukaitienė Vilius Skipskis Lolita Kuršvietienė Julius Liobikas |
| author_sort | Aušra Mongirdienė |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: It is known that neutrophils are involved in the pro-inflammatory processes and thus, can have a great impact on the pathophysiology of heart failure (HF). Moreover, hypercholesterolemia heightens neutrophil production, thereby accelerating cardiovascular inflammation. However, there is a lack of information about the relation of low inflammation to the state of stress, hypercholesterolemia, and pro-thrombotic statement in patients with chronic HF. Therefore, we aimed to determine whether platelet, cholesterol and cortisol levels differ in a different inflammatory condition groups according to the neutrophil count in patients diagnosed with CHF with reduced ejection fraction (CHFrEF), and whether there is a correlation between those readings. <i>Materials and Methods:</i> The average of neutrophil count was 4.37 × 10<sup>9</sup> L; therefore, 180 patients were separated into two groups: one with relatively a higher inflammatory environment (neutrophil count ≥ 4.37 × 10<sup>9</sup> L (<i>n</i> = 97)) and one with a relatively lower inflammatory environment (neutrophil count < 4.38 × 10<sup>9</sup> L (<i>n</i> = 83)). We also determined the levels of lymphocytes, monocytes, platelet count (PLT), mean platelet volume (MPV), platelet aggregation, the levels of cortisol and cholesterol and the concentrations of C reactive protein (CRP) and fibrinogen. <i>Results:</i> We found that CRP, fibrinogen and cortisol concentrations were statistically significantly higher in the group with higher neutrophil counts. However, there were no differences among cholesterol concentration and other markers of platelet function between the groups. We also showed that PLT, leukocyte and monocyte counts were higher in the group with a higher neutrophil count, and the PLT correlated with other cell type count and CRP. In addition, the neutrophil count correlated with concentrations of fibrinogen, evening cortisol and CRP. <i>Conclusions:</i> Cortisol, fibrinogen and CRP levels, PLT and monocyte counts were higher in the CHFrEF patient group with higher neutrophil counts. The cholesterol levels and platelet function readings did not differ between the groups. The neutrophil count correlated with evening cortisol concentration. |
| first_indexed | 2024-03-10T10:49:22Z |
| format | Article |
| id | doaj.art-fede7848bcaa42bcb32dfd316e46d64f |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T10:49:22Z |
| publishDate | 2021-06-01 |
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| series | Medicina |
| spelling | doaj.art-fede7848bcaa42bcb32dfd316e46d64f2023-11-21T22:21:36ZengMDPI AGMedicina1010-660X1648-91442021-06-0157655710.3390/medicina57060557The Difference of Cholesterol, Platelet and Cortisol Levels in Patients Diagnosed with Chronic Heart Failure with Reduced Ejection Fraction Groups According to Neutrophil CountAušra Mongirdienė0Jolanta Laukaitienė1Vilius Skipskis2Lolita Kuršvietienė3Julius Liobikas4Department of Biochemistry, Medicine Academy, Lithuanian University of Health Sciences, Eiveniu Str. 4, LT-50103 Kaunas, LithuaniaDepartment of Biochemistry, Medicine Academy, Lithuanian University of Health Sciences, Eiveniu Str. 4, LT-50103 Kaunas, LithuaniaLaboratory of Molecular Cardiology, Institute of Cardiology, Lithuanian University of Health Sciences, Sukilėlių pr.15, LT-50103 Kaunas, LithuaniaDepartment of Biochemistry, Medicine Academy, Lithuanian University of Health Sciences, Eiveniu Str. 4, LT-50103 Kaunas, LithuaniaDepartment of Biochemistry, Medicine Academy, Lithuanian University of Health Sciences, Eiveniu Str. 4, LT-50103 Kaunas, Lithuania<i>Background and Objectives</i>: It is known that neutrophils are involved in the pro-inflammatory processes and thus, can have a great impact on the pathophysiology of heart failure (HF). Moreover, hypercholesterolemia heightens neutrophil production, thereby accelerating cardiovascular inflammation. However, there is a lack of information about the relation of low inflammation to the state of stress, hypercholesterolemia, and pro-thrombotic statement in patients with chronic HF. Therefore, we aimed to determine whether platelet, cholesterol and cortisol levels differ in a different inflammatory condition groups according to the neutrophil count in patients diagnosed with CHF with reduced ejection fraction (CHFrEF), and whether there is a correlation between those readings. <i>Materials and Methods:</i> The average of neutrophil count was 4.37 × 10<sup>9</sup> L; therefore, 180 patients were separated into two groups: one with relatively a higher inflammatory environment (neutrophil count ≥ 4.37 × 10<sup>9</sup> L (<i>n</i> = 97)) and one with a relatively lower inflammatory environment (neutrophil count < 4.38 × 10<sup>9</sup> L (<i>n</i> = 83)). We also determined the levels of lymphocytes, monocytes, platelet count (PLT), mean platelet volume (MPV), platelet aggregation, the levels of cortisol and cholesterol and the concentrations of C reactive protein (CRP) and fibrinogen. <i>Results:</i> We found that CRP, fibrinogen and cortisol concentrations were statistically significantly higher in the group with higher neutrophil counts. However, there were no differences among cholesterol concentration and other markers of platelet function between the groups. We also showed that PLT, leukocyte and monocyte counts were higher in the group with a higher neutrophil count, and the PLT correlated with other cell type count and CRP. In addition, the neutrophil count correlated with concentrations of fibrinogen, evening cortisol and CRP. <i>Conclusions:</i> Cortisol, fibrinogen and CRP levels, PLT and monocyte counts were higher in the CHFrEF patient group with higher neutrophil counts. The cholesterol levels and platelet function readings did not differ between the groups. The neutrophil count correlated with evening cortisol concentration.https://www.mdpi.com/1648-9144/57/6/557plateletneutrophilmonocytelymphocytecortisolheart failure |
| spellingShingle | Aušra Mongirdienė Jolanta Laukaitienė Vilius Skipskis Lolita Kuršvietienė Julius Liobikas The Difference of Cholesterol, Platelet and Cortisol Levels in Patients Diagnosed with Chronic Heart Failure with Reduced Ejection Fraction Groups According to Neutrophil Count Medicina platelet neutrophil monocyte lymphocyte cortisol heart failure |
| title | The Difference of Cholesterol, Platelet and Cortisol Levels in Patients Diagnosed with Chronic Heart Failure with Reduced Ejection Fraction Groups According to Neutrophil Count |
| title_full | The Difference of Cholesterol, Platelet and Cortisol Levels in Patients Diagnosed with Chronic Heart Failure with Reduced Ejection Fraction Groups According to Neutrophil Count |
| title_fullStr | The Difference of Cholesterol, Platelet and Cortisol Levels in Patients Diagnosed with Chronic Heart Failure with Reduced Ejection Fraction Groups According to Neutrophil Count |
| title_full_unstemmed | The Difference of Cholesterol, Platelet and Cortisol Levels in Patients Diagnosed with Chronic Heart Failure with Reduced Ejection Fraction Groups According to Neutrophil Count |
| title_short | The Difference of Cholesterol, Platelet and Cortisol Levels in Patients Diagnosed with Chronic Heart Failure with Reduced Ejection Fraction Groups According to Neutrophil Count |
| title_sort | difference of cholesterol platelet and cortisol levels in patients diagnosed with chronic heart failure with reduced ejection fraction groups according to neutrophil count |
| topic | platelet neutrophil monocyte lymphocyte cortisol heart failure |
| url | https://www.mdpi.com/1648-9144/57/6/557 |
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