STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor.

STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor.

Dengue virus (DENV) is a mosquito-borne flavivirus, and symptoms of infection range from asymptomatic to the severe dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). High viral loads correlate with disease severity, and both type I & II interferons (IFNs) are crucial for controlling vira...

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Bibliographic Details
Main Authors: Stuart T Perry, Michael D Buck, Steven M Lada, Christian Schindler, Sujan Shresta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3040673?pdf=render

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