mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients
Malignant melanoma is one of the most aggressive forms of cancer and the leading cause of death from skin tumors. Given the increased incidence of melanoma diagnoses in recent years, it is essential to develop effective treatments to control this disease. In this regard, the use of cancer vaccines t...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/10/1060 |
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| author | Maryam Bidram Yue Zhao Natalia G. Shebardina Alexey V. Baldin Alexandr V. Bazhin Mohamad Reza Ganjalikhany Andrey A. Zamyatnin Mazdak Ganjalikhani-hakemi |
| author_facet | Maryam Bidram Yue Zhao Natalia G. Shebardina Alexey V. Baldin Alexandr V. Bazhin Mohamad Reza Ganjalikhany Andrey A. Zamyatnin Mazdak Ganjalikhani-hakemi |
| author_sort | Maryam Bidram |
| collection | DOAJ |
| description | Malignant melanoma is one of the most aggressive forms of cancer and the leading cause of death from skin tumors. Given the increased incidence of melanoma diagnoses in recent years, it is essential to develop effective treatments to control this disease. In this regard, the use of cancer vaccines to enhance cell-mediated immunity is considered to be one of the most modern immunotherapy options for cancer treatment. The most recent cancer vaccine options are mRNA vaccines, with a focus on their usage as modern treatments. Advantages of mRNA cancer vaccines include their rapid production and low manufacturing costs. mRNA-based vaccines are also able to induce both humoral and cellular immune responses. In addition to the many advantages of mRNA vaccines for the treatment of cancer, their use is associated with a number of challenges. For this reason, before mRNA vaccines can be used for the treatment of cancer, comprehensive information about them is required and a large number of trials need to be conducted. Here, we reviewed the general features of mRNA vaccines, including their basis, stabilization, and delivery methods. We also covered clinical trials involving the use of mRNA vaccines in melanoma cancer and the challenges involved with this type of treatment. This review also emphasized the combination of treatment with mRNA vaccines with the use of immune-checkpoint blockers to enhance cell-mediated immunity. |
| first_indexed | 2024-03-10T06:10:01Z |
| format | Article |
| id | doaj.art-fee0951c76bf441bb6e7f03695567e1f |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T06:10:01Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-fee0951c76bf441bb6e7f03695567e1f2023-11-22T20:14:29ZengMDPI AGVaccines2076-393X2021-09-01910106010.3390/vaccines9101060mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma PatientsMaryam Bidram0Yue Zhao1Natalia G. Shebardina2Alexey V. Baldin3Alexandr V. Bazhin4Mohamad Reza Ganjalikhany5Andrey A. Zamyatnin6Mazdak Ganjalikhani-hakemi7Department of Cell and Molecular Biology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan 8174673441, IranDepartment of General, Visceral and Transplant Surgery, Ludwig-Maximilians University of Munich, 81377 Munich, GermanyInstitute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, RussiaBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, RussiaDepartment of General, Visceral and Transplant Surgery, Ludwig-Maximilians University of Munich, 81377 Munich, GermanyDepartment of Cell and Molecular Biology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan 8174673441, IranInstitute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, RussiaDepartment of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan 8174673441, IranMalignant melanoma is one of the most aggressive forms of cancer and the leading cause of death from skin tumors. Given the increased incidence of melanoma diagnoses in recent years, it is essential to develop effective treatments to control this disease. In this regard, the use of cancer vaccines to enhance cell-mediated immunity is considered to be one of the most modern immunotherapy options for cancer treatment. The most recent cancer vaccine options are mRNA vaccines, with a focus on their usage as modern treatments. Advantages of mRNA cancer vaccines include their rapid production and low manufacturing costs. mRNA-based vaccines are also able to induce both humoral and cellular immune responses. In addition to the many advantages of mRNA vaccines for the treatment of cancer, their use is associated with a number of challenges. For this reason, before mRNA vaccines can be used for the treatment of cancer, comprehensive information about them is required and a large number of trials need to be conducted. Here, we reviewed the general features of mRNA vaccines, including their basis, stabilization, and delivery methods. We also covered clinical trials involving the use of mRNA vaccines in melanoma cancer and the challenges involved with this type of treatment. This review also emphasized the combination of treatment with mRNA vaccines with the use of immune-checkpoint blockers to enhance cell-mediated immunity.https://www.mdpi.com/2076-393X/9/10/1060melanoma cancermRNA vaccinetherapeuticdelivery systemsimmune checkpoint |
| spellingShingle | Maryam Bidram Yue Zhao Natalia G. Shebardina Alexey V. Baldin Alexandr V. Bazhin Mohamad Reza Ganjalikhany Andrey A. Zamyatnin Mazdak Ganjalikhani-hakemi mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients Vaccines melanoma cancer mRNA vaccine therapeutic delivery systems immune checkpoint |
| title | mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients |
| title_full | mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients |
| title_fullStr | mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients |
| title_full_unstemmed | mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients |
| title_short | mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients |
| title_sort | mrna based cancer vaccines a therapeutic strategy for the treatment of melanoma patients |
| topic | melanoma cancer mRNA vaccine therapeutic delivery systems immune checkpoint |
| url | https://www.mdpi.com/2076-393X/9/10/1060 |
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