Potent immune responses induced by a Salmonella ghost delivery system that expresses the recombinant Stx2eB, FedF, and FedA proteins of the Escherichia coli-producing F18 and Shiga toxin in a murine model and evaluation of its protective effect as a porcine vaccine candidate

Potent immune responses induced by a Salmonella ghost delivery system that expresses the recombinant Stx2eB, FedF, and FedA proteins of the Escherichia coli-producing F18 and Shiga toxin in a murine model and evaluation of its protective effect as a porcine vaccine candidate

Background: In the pathogenicity of porcine edema disease (ED), which is caused by the Escherichia coli-producing F18 and Shiga toxin, F18+ fimbrial adhesins and Shiga toxin 2e (Stx2e) play pivotal roles in the colonization and enterotoxicity of this pathogen. Objective: To develop a vaccine candida...

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Bibliographic Details
Main Authors: Gayeon Won, Lee John Hwa
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Veterinary Quarterly
Subjects:
Porcine edema disease
Shiga toxin 2e
F18+ fimbrial adhesion
bacterial ghost
murine model
vaccine
Online Access:http://dx.doi.org/10.1080/01652176.2017.1308040

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