The Biogenesis of miRNAs and Their Role in the Development of Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects upper and lower motor neurons. As there is no effective treatment for ALS, it is particularly important to screen key gene therapy targets. The identifications of microRNAs (miRNAs) have completely changed the traditiona...
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MDPI AG
2022-02-01
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| Online Access: | https://www.mdpi.com/2073-4409/11/3/572 |
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| author | Jinmeng Liu Fenghua Zhou Yingjun Guan Fandi Meng Zhenhan Zhao Qi Su Weiwei Bao Xuemei Wang Jiantao Zhao Zijun Huo Lingyun Zhang Shuanhu Zhou Yanchun Chen Xin Wang |
| author_facet | Jinmeng Liu Fenghua Zhou Yingjun Guan Fandi Meng Zhenhan Zhao Qi Su Weiwei Bao Xuemei Wang Jiantao Zhao Zijun Huo Lingyun Zhang Shuanhu Zhou Yanchun Chen Xin Wang |
| author_sort | Jinmeng Liu |
| collection | DOAJ |
| description | Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects upper and lower motor neurons. As there is no effective treatment for ALS, it is particularly important to screen key gene therapy targets. The identifications of microRNAs (miRNAs) have completely changed the traditional view of gene regulation. miRNAs are small noncoding single-stranded RNA molecules involved in the regulation of post-transcriptional gene expression. Recent advances also indicate that miRNAs are biomarkers in many diseases, including neurodegenerative diseases. In this review, we summarize recent advances regarding the mechanisms underlying the role of miRNAs in ALS pathogenesis and its application to gene therapy for ALS. The potential of miRNAs to target diverse pathways opens a new avenue for ALS therapy. |
| first_indexed | 2024-03-10T00:02:54Z |
| format | Article |
| id | doaj.art-fee28e9d6e1248e18b9a92ae7a9c5189 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:02:54Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-fee28e9d6e1248e18b9a92ae7a9c51892023-11-23T16:14:14ZengMDPI AGCells2073-44092022-02-0111357210.3390/cells11030572The Biogenesis of miRNAs and Their Role in the Development of Amyotrophic Lateral SclerosisJinmeng Liu0Fenghua Zhou1Yingjun Guan2Fandi Meng3Zhenhan Zhao4Qi Su5Weiwei Bao6Xuemei Wang7Jiantao Zhao8Zijun Huo9Lingyun Zhang10Shuanhu Zhou11Yanchun Chen12Xin Wang13Laboratory of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, ChinaNeurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaNeurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, ChinaDepartment of Histology and Embryology, School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, ChinaNeurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaDepartment of Orthopedic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USANeurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, ChinaDepartment of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USAAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects upper and lower motor neurons. As there is no effective treatment for ALS, it is particularly important to screen key gene therapy targets. The identifications of microRNAs (miRNAs) have completely changed the traditional view of gene regulation. miRNAs are small noncoding single-stranded RNA molecules involved in the regulation of post-transcriptional gene expression. Recent advances also indicate that miRNAs are biomarkers in many diseases, including neurodegenerative diseases. In this review, we summarize recent advances regarding the mechanisms underlying the role of miRNAs in ALS pathogenesis and its application to gene therapy for ALS. The potential of miRNAs to target diverse pathways opens a new avenue for ALS therapy.https://www.mdpi.com/2073-4409/11/3/572amyotrophic lateral sclerosismiRNAsnoncoding RNAbiomarkertherapyneurodegeneration |
| spellingShingle | Jinmeng Liu Fenghua Zhou Yingjun Guan Fandi Meng Zhenhan Zhao Qi Su Weiwei Bao Xuemei Wang Jiantao Zhao Zijun Huo Lingyun Zhang Shuanhu Zhou Yanchun Chen Xin Wang The Biogenesis of miRNAs and Their Role in the Development of Amyotrophic Lateral Sclerosis Cells amyotrophic lateral sclerosis miRNAs noncoding RNA biomarker therapy neurodegeneration |
| title | The Biogenesis of miRNAs and Their Role in the Development of Amyotrophic Lateral Sclerosis |
| title_full | The Biogenesis of miRNAs and Their Role in the Development of Amyotrophic Lateral Sclerosis |
| title_fullStr | The Biogenesis of miRNAs and Their Role in the Development of Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | The Biogenesis of miRNAs and Their Role in the Development of Amyotrophic Lateral Sclerosis |
| title_short | The Biogenesis of miRNAs and Their Role in the Development of Amyotrophic Lateral Sclerosis |
| title_sort | biogenesis of mirnas and their role in the development of amyotrophic lateral sclerosis |
| topic | amyotrophic lateral sclerosis miRNAs noncoding RNA biomarker therapy neurodegeneration |
| url | https://www.mdpi.com/2073-4409/11/3/572 |
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