The Role of RNA-Binding Proteins in Hematological Malignancies
Hematological malignancies comprise a plethora of different neoplasms, such as leukemia, lymphoma, and myeloma, plus a myriad of dysplasia, such as myelodysplastic syndromes or anemias. Despite all the advances in patient care and the development of new therapies, some of these malignancies remain i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/17/9552 |
| _version_ | 1797495362946072576 |
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| author | Pedro Aguilar-Garrido Álvaro Otero-Sobrino Miguel Ángel Navarro-Aguadero María Velasco-Estévez Miguel Gallardo |
| author_facet | Pedro Aguilar-Garrido Álvaro Otero-Sobrino Miguel Ángel Navarro-Aguadero María Velasco-Estévez Miguel Gallardo |
| author_sort | Pedro Aguilar-Garrido |
| collection | DOAJ |
| description | Hematological malignancies comprise a plethora of different neoplasms, such as leukemia, lymphoma, and myeloma, plus a myriad of dysplasia, such as myelodysplastic syndromes or anemias. Despite all the advances in patient care and the development of new therapies, some of these malignancies remain incurable, mainly due to resistance and refractoriness to treatment. Therefore, there is an unmet clinical need to identify new biomarkers and potential therapeutic targets that play a role in treatment resistance and contribute to the poor outcomes of these tumors. RNA-binding proteins (RBPs) are a diverse class of proteins that interact with transcripts and noncoding RNAs and are involved in every step of the post-transcriptional processing of transcripts. Dysregulation of RBPs has been associated with the development of hematological malignancies, making them potential valuable biomarkers and potential therapeutic targets. Although a number of dysregulated RBPs have been identified in hematological malignancies, there is a critical need to understand the biology underlying their contribution to pathology, such as the spatiotemporal context and molecular mechanisms involved. In this review, we emphasize the importance of deciphering the regulatory mechanisms of RBPs to pinpoint novel therapeutic targets that could drive or contribute to hematological malignancy biology. |
| first_indexed | 2024-03-10T01:47:43Z |
| format | Article |
| id | doaj.art-fee3c0235f4347e98e388a64119e9091 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:47:43Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fee3c0235f4347e98e388a64119e90912023-11-23T13:12:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012317955210.3390/ijms23179552The Role of RNA-Binding Proteins in Hematological MalignanciesPedro Aguilar-Garrido0Álvaro Otero-Sobrino1Miguel Ángel Navarro-Aguadero2María Velasco-Estévez3Miguel Gallardo4H12O-CNIO Hematological Malignancies Clinical Research Unit, CNIO, 28029 Madrid, SpainH12O-CNIO Hematological Malignancies Clinical Research Unit, CNIO, 28029 Madrid, SpainH12O-CNIO Hematological Malignancies Clinical Research Unit, CNIO, 28029 Madrid, SpainH12O-CNIO Hematological Malignancies Clinical Research Unit, CNIO, 28029 Madrid, SpainH12O-CNIO Hematological Malignancies Clinical Research Unit, CNIO, 28029 Madrid, SpainHematological malignancies comprise a plethora of different neoplasms, such as leukemia, lymphoma, and myeloma, plus a myriad of dysplasia, such as myelodysplastic syndromes or anemias. Despite all the advances in patient care and the development of new therapies, some of these malignancies remain incurable, mainly due to resistance and refractoriness to treatment. Therefore, there is an unmet clinical need to identify new biomarkers and potential therapeutic targets that play a role in treatment resistance and contribute to the poor outcomes of these tumors. RNA-binding proteins (RBPs) are a diverse class of proteins that interact with transcripts and noncoding RNAs and are involved in every step of the post-transcriptional processing of transcripts. Dysregulation of RBPs has been associated with the development of hematological malignancies, making them potential valuable biomarkers and potential therapeutic targets. Although a number of dysregulated RBPs have been identified in hematological malignancies, there is a critical need to understand the biology underlying their contribution to pathology, such as the spatiotemporal context and molecular mechanisms involved. In this review, we emphasize the importance of deciphering the regulatory mechanisms of RBPs to pinpoint novel therapeutic targets that could drive or contribute to hematological malignancy biology.https://www.mdpi.com/1422-0067/23/17/9552RNA-binding proteinsleukemialymphomamyelomadysplasia |
| spellingShingle | Pedro Aguilar-Garrido Álvaro Otero-Sobrino Miguel Ángel Navarro-Aguadero María Velasco-Estévez Miguel Gallardo The Role of RNA-Binding Proteins in Hematological Malignancies International Journal of Molecular Sciences RNA-binding proteins leukemia lymphoma myeloma dysplasia |
| title | The Role of RNA-Binding Proteins in Hematological Malignancies |
| title_full | The Role of RNA-Binding Proteins in Hematological Malignancies |
| title_fullStr | The Role of RNA-Binding Proteins in Hematological Malignancies |
| title_full_unstemmed | The Role of RNA-Binding Proteins in Hematological Malignancies |
| title_short | The Role of RNA-Binding Proteins in Hematological Malignancies |
| title_sort | role of rna binding proteins in hematological malignancies |
| topic | RNA-binding proteins leukemia lymphoma myeloma dysplasia |
| url | https://www.mdpi.com/1422-0067/23/17/9552 |
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