Effectiveness of Dupilumab in the Treatment of Patients with Uncontrolled Severe CRSwNP: A “Real-Life” Observational Study in Naïve and Post-Surgical Patients
<b><i>Background</i></b>: Chronic rhinosinusitis with nasal polyps (CRSwNP) represents 25–30% of all CRS cases, and in the most severe forms it is associated with a poor quality of life and a high rate of nasal polyps’ recurrence after surgery. Dupilumab has been suggested as...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/12/9/1526 |
| _version_ | 1797486065247846400 |
|---|---|
| author | Giancarlo Ottaviano Tommaso Saccardo Giuseppe Roccuzzo Riccardo Bernardi Alessandra Di Chicco Alfonso Luca Pendolino Bruno Scarpa Edoardo Mairani Piero Nicolai |
| author_facet | Giancarlo Ottaviano Tommaso Saccardo Giuseppe Roccuzzo Riccardo Bernardi Alessandra Di Chicco Alfonso Luca Pendolino Bruno Scarpa Edoardo Mairani Piero Nicolai |
| author_sort | Giancarlo Ottaviano |
| collection | DOAJ |
| description | <b><i>Background</i></b>: Chronic rhinosinusitis with nasal polyps (CRSwNP) represents 25–30% of all CRS cases, and in the most severe forms it is associated with a poor quality of life and a high rate of nasal polyps’ recurrence after surgery. Dupilumab has been suggested as a treatment option for severe CRSwNP. <b><i>Methods</i></b>: Patients with severe CRSwNP receiving dupilumab from January 2021 were followed up at 1, 3, 6, 9 and 12 months from the first administration and were considered for this study. At baseline and at each follow-up, patients underwent nasal endoscopy and completed the Sinonasal Outcome Test (SNOT)-22, a Visual Analogue Scale (VAS) for smell/nasal obstruction, the Nasal Congestion Score and the Asthma Control Test. Peak nasal inspiratory flow (PNIF), a smell test, nasal cytology and blood eosinophilia were also evaluated. <b><i>Results</i></b>: Forty-seven patients were included in the study. Of these, 33 patients had a history of previous surgery (ESS) and had recurrent nasal polyps, while 14 patients were naïve to nasal surgery. Both subjective and objective parameters improved after biological treatment and were correlated with each other (<i>p</i> < 0.05), except for the SNOT-22 and the nasal polyp’s score. No correlations were found between nasal and blood eosinophilia. No differences were observed when comparing the post-surgical and the naïve groups. <b><i>Conclusions</i></b>: Dupilumab improves nasal obstruction and the sense of smell and reduces the level of local inflammation in severe CRSwNP patients in a similar way in both naïve and post-surgical patients. |
| first_indexed | 2024-03-09T23:28:51Z |
| format | Article |
| id | doaj.art-fee4df989d05498cbebf9ffe8c0c5a29 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T23:28:51Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-fee4df989d05498cbebf9ffe8c0c5a292023-11-23T17:14:39ZengMDPI AGJournal of Personalized Medicine2075-44262022-09-01129152610.3390/jpm12091526Effectiveness of Dupilumab in the Treatment of Patients with Uncontrolled Severe CRSwNP: A “Real-Life” Observational Study in Naïve and Post-Surgical PatientsGiancarlo Ottaviano0Tommaso Saccardo1Giuseppe Roccuzzo2Riccardo Bernardi3Alessandra Di Chicco4Alfonso Luca Pendolino5Bruno Scarpa6Edoardo Mairani7Piero Nicolai8Department of Neuroscience DNS, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128 Padova, ItalyDepartment of Neuroscience DNS, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128 Padova, ItalyDepartment of Neuroscience DNS, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128 Padova, ItalyDepartment of Neuroscience DNS, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128 Padova, ItalyDepartment of Neuroscience DNS, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128 Padova, ItalyDepartment of ENT, Royal National ENT and Eastman Dental Hospitals, London WC1E 6DG, UKDepartment of Statistical Sciences and Department of Mathematics Tullio Levi-Civita, University of Padova, 35128 Padova, ItalyDepartment of Neuroscience DNS, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128 Padova, ItalyDepartment of Neuroscience DNS, Otolaryngology Section, University of Padova, Via Giustiniani 2, 35128 Padova, Italy<b><i>Background</i></b>: Chronic rhinosinusitis with nasal polyps (CRSwNP) represents 25–30% of all CRS cases, and in the most severe forms it is associated with a poor quality of life and a high rate of nasal polyps’ recurrence after surgery. Dupilumab has been suggested as a treatment option for severe CRSwNP. <b><i>Methods</i></b>: Patients with severe CRSwNP receiving dupilumab from January 2021 were followed up at 1, 3, 6, 9 and 12 months from the first administration and were considered for this study. At baseline and at each follow-up, patients underwent nasal endoscopy and completed the Sinonasal Outcome Test (SNOT)-22, a Visual Analogue Scale (VAS) for smell/nasal obstruction, the Nasal Congestion Score and the Asthma Control Test. Peak nasal inspiratory flow (PNIF), a smell test, nasal cytology and blood eosinophilia were also evaluated. <b><i>Results</i></b>: Forty-seven patients were included in the study. Of these, 33 patients had a history of previous surgery (ESS) and had recurrent nasal polyps, while 14 patients were naïve to nasal surgery. Both subjective and objective parameters improved after biological treatment and were correlated with each other (<i>p</i> < 0.05), except for the SNOT-22 and the nasal polyp’s score. No correlations were found between nasal and blood eosinophilia. No differences were observed when comparing the post-surgical and the naïve groups. <b><i>Conclusions</i></b>: Dupilumab improves nasal obstruction and the sense of smell and reduces the level of local inflammation in severe CRSwNP patients in a similar way in both naïve and post-surgical patients.https://www.mdpi.com/2075-4426/12/9/1526dupilumabPNIFnasal cytologySNOT-22NPSACT |
| spellingShingle | Giancarlo Ottaviano Tommaso Saccardo Giuseppe Roccuzzo Riccardo Bernardi Alessandra Di Chicco Alfonso Luca Pendolino Bruno Scarpa Edoardo Mairani Piero Nicolai Effectiveness of Dupilumab in the Treatment of Patients with Uncontrolled Severe CRSwNP: A “Real-Life” Observational Study in Naïve and Post-Surgical Patients Journal of Personalized Medicine dupilumab PNIF nasal cytology SNOT-22 NPS ACT |
| title | Effectiveness of Dupilumab in the Treatment of Patients with Uncontrolled Severe CRSwNP: A “Real-Life” Observational Study in Naïve and Post-Surgical Patients |
| title_full | Effectiveness of Dupilumab in the Treatment of Patients with Uncontrolled Severe CRSwNP: A “Real-Life” Observational Study in Naïve and Post-Surgical Patients |
| title_fullStr | Effectiveness of Dupilumab in the Treatment of Patients with Uncontrolled Severe CRSwNP: A “Real-Life” Observational Study in Naïve and Post-Surgical Patients |
| title_full_unstemmed | Effectiveness of Dupilumab in the Treatment of Patients with Uncontrolled Severe CRSwNP: A “Real-Life” Observational Study in Naïve and Post-Surgical Patients |
| title_short | Effectiveness of Dupilumab in the Treatment of Patients with Uncontrolled Severe CRSwNP: A “Real-Life” Observational Study in Naïve and Post-Surgical Patients |
| title_sort | effectiveness of dupilumab in the treatment of patients with uncontrolled severe crswnp a real life observational study in naive and post surgical patients |
| topic | dupilumab PNIF nasal cytology SNOT-22 NPS ACT |
| url | https://www.mdpi.com/2075-4426/12/9/1526 |
| work_keys_str_mv | AT giancarloottaviano effectivenessofdupilumabinthetreatmentofpatientswithuncontrolledseverecrswnpareallifeobservationalstudyinnaiveandpostsurgicalpatients AT tommasosaccardo effectivenessofdupilumabinthetreatmentofpatientswithuncontrolledseverecrswnpareallifeobservationalstudyinnaiveandpostsurgicalpatients AT giusepperoccuzzo effectivenessofdupilumabinthetreatmentofpatientswithuncontrolledseverecrswnpareallifeobservationalstudyinnaiveandpostsurgicalpatients AT riccardobernardi effectivenessofdupilumabinthetreatmentofpatientswithuncontrolledseverecrswnpareallifeobservationalstudyinnaiveandpostsurgicalpatients AT alessandradichicco effectivenessofdupilumabinthetreatmentofpatientswithuncontrolledseverecrswnpareallifeobservationalstudyinnaiveandpostsurgicalpatients AT alfonsolucapendolino effectivenessofdupilumabinthetreatmentofpatientswithuncontrolledseverecrswnpareallifeobservationalstudyinnaiveandpostsurgicalpatients AT brunoscarpa effectivenessofdupilumabinthetreatmentofpatientswithuncontrolledseverecrswnpareallifeobservationalstudyinnaiveandpostsurgicalpatients AT edoardomairani effectivenessofdupilumabinthetreatmentofpatientswithuncontrolledseverecrswnpareallifeobservationalstudyinnaiveandpostsurgicalpatients AT pieronicolai effectivenessofdupilumabinthetreatmentofpatientswithuncontrolledseverecrswnpareallifeobservationalstudyinnaiveandpostsurgicalpatients |