Study of effectiveness of enrofloxacin and moxifloxacin in experimental salmonellosis of chickens
In this publication we present a comparative study of effectiveness of enrofloxacin and moxifloxacin for treatment of chickens, experimentally infected with Salmonella infantis. The chickens received both drugs in water-soluble form via drinking water ad libitum at concentrations of 200 mg/L, 100 mg...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2021-01-01
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| Series: | BIO Web of Conferences |
| Subjects: | |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2021/12/bioconf_ils21_01003.pdf |
| _version_ | 1818964804095705088 |
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| author | Skvortsov Vladimir Yurin Dmitry Tarasova Julia Kapustin Andrey Laishevtsev Alexey |
| author_facet | Skvortsov Vladimir Yurin Dmitry Tarasova Julia Kapustin Andrey Laishevtsev Alexey |
| author_sort | Skvortsov Vladimir |
| collection | DOAJ |
| description | In this publication we present a comparative study of effectiveness of enrofloxacin and moxifloxacin for treatment of chickens, experimentally infected with Salmonella infantis. The chickens received both drugs in water-soluble form via drinking water ad libitum at concentrations of 200 mg/L, 100 mg/L, 50 mg/L and 25 mg/L one day before the challenge and then four consecutive days. The chickens were challenged by intraperitoneal injection with 150 million CFUs of one-day old agar culture of S. infantis in 0.5 mL isotonic saline. The observation period was 15 days. Enrofloxacin proved most effective (88% and 84%) at concentrations of 200 mg/L and 100 mg/L. Lower concentrations caused a decrease in its effectiveness. When enrofloxacin was administered at a concentration of 50 mg/L the survival rate for chickens was 64%. The effectiveness of moxifloxacin in our experiment was considerably lower. The survival rate for chickens, receiving moxifloxacin at concentrations 200 mg/L, 100 mg/L, 50 mg/L and 25 mg/L was respectively 32%, 28%, 32% and 16%, and their average lifespan was half as long as of those groups, receiving enrofloxacin. The results of our research prove the high effectiveness of enrofloxacin at a concentration 200 mg/L in drinking water for the treatment of experimental salmonellosis in chickens. |
| first_indexed | 2024-12-20T13:06:56Z |
| format | Article |
| id | doaj.art-fee6fb553e6e45219f003e7e43188950 |
| institution | Directory Open Access Journal |
| issn | 2117-4458 |
| language | English |
| last_indexed | 2024-12-20T13:06:56Z |
| publishDate | 2021-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj.art-fee6fb553e6e45219f003e7e431889502022-12-21T19:39:46ZengEDP SciencesBIO Web of Conferences2117-44582021-01-01400100310.1051/bioconf/20214001003bioconf_ils21_01003Study of effectiveness of enrofloxacin and moxifloxacin in experimental salmonellosis of chickensSkvortsov VladimirYurin DmitryTarasova JuliaKapustin AndreyLaishevtsev AlexeyIn this publication we present a comparative study of effectiveness of enrofloxacin and moxifloxacin for treatment of chickens, experimentally infected with Salmonella infantis. The chickens received both drugs in water-soluble form via drinking water ad libitum at concentrations of 200 mg/L, 100 mg/L, 50 mg/L and 25 mg/L one day before the challenge and then four consecutive days. The chickens were challenged by intraperitoneal injection with 150 million CFUs of one-day old agar culture of S. infantis in 0.5 mL isotonic saline. The observation period was 15 days. Enrofloxacin proved most effective (88% and 84%) at concentrations of 200 mg/L and 100 mg/L. Lower concentrations caused a decrease in its effectiveness. When enrofloxacin was administered at a concentration of 50 mg/L the survival rate for chickens was 64%. The effectiveness of moxifloxacin in our experiment was considerably lower. The survival rate for chickens, receiving moxifloxacin at concentrations 200 mg/L, 100 mg/L, 50 mg/L and 25 mg/L was respectively 32%, 28%, 32% and 16%, and their average lifespan was half as long as of those groups, receiving enrofloxacin. The results of our research prove the high effectiveness of enrofloxacin at a concentration 200 mg/L in drinking water for the treatment of experimental salmonellosis in chickens.https://www.bio-conferences.org/articles/bioconf/pdf/2021/12/bioconf_ils21_01003.pdfendofloxacinmoxifloxacinsalmonellosischicken |
| spellingShingle | Skvortsov Vladimir Yurin Dmitry Tarasova Julia Kapustin Andrey Laishevtsev Alexey Study of effectiveness of enrofloxacin and moxifloxacin in experimental salmonellosis of chickens BIO Web of Conferences endofloxacin moxifloxacin salmonellosis chicken |
| title | Study of effectiveness of enrofloxacin and moxifloxacin in experimental salmonellosis of chickens |
| title_full | Study of effectiveness of enrofloxacin and moxifloxacin in experimental salmonellosis of chickens |
| title_fullStr | Study of effectiveness of enrofloxacin and moxifloxacin in experimental salmonellosis of chickens |
| title_full_unstemmed | Study of effectiveness of enrofloxacin and moxifloxacin in experimental salmonellosis of chickens |
| title_short | Study of effectiveness of enrofloxacin and moxifloxacin in experimental salmonellosis of chickens |
| title_sort | study of effectiveness of enrofloxacin and moxifloxacin in experimental salmonellosis of chickens |
| topic | endofloxacin moxifloxacin salmonellosis chicken |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2021/12/bioconf_ils21_01003.pdf |
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