Familial and socioeconomic contributions to premorbid functioning in psychosis: Impact on age at onset and treatment response
AbstractBackground.Premorbid adjustment (PA) abnormalities in psychotic disorders are associated with an earlier age at onset (AAO) and unfavorable clinical outcomes, including treatment resistance. Prior family studies suggest that familial liability, likely reflecting increased genetic risk, and s...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2020-01-01
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| Series: | European Psychiatry |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933820000413/type/journal_article |
| _version_ | 1827995015717060608 |
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| author | Alex Hatzimanolis Pentagiotissa Stefanatou Emmanouil Kattoulas Irene Ralli Stefanos Dimitrakopoulos Stefania Foteli Ioannis Kosteletos Leonidas Mantonakis Mirjana Selakovic Rigas-Filippos Soldatos Ilias Vlachos Lida-Alkisti Xenaki Nikolaos Smyrnis Nicholas C. Stefanis |
| author_facet | Alex Hatzimanolis Pentagiotissa Stefanatou Emmanouil Kattoulas Irene Ralli Stefanos Dimitrakopoulos Stefania Foteli Ioannis Kosteletos Leonidas Mantonakis Mirjana Selakovic Rigas-Filippos Soldatos Ilias Vlachos Lida-Alkisti Xenaki Nikolaos Smyrnis Nicholas C. Stefanis |
| author_sort | Alex Hatzimanolis |
| collection | DOAJ |
| description | AbstractBackground.Premorbid adjustment (PA) abnormalities in psychotic disorders are associated with an earlier age at onset (AAO) and unfavorable clinical outcomes, including treatment resistance. Prior family studies suggest that familial liability, likely reflecting increased genetic risk, and socioeconomic status (SES) contribute to premorbid maladjustment. However, their joint effect possibly indicating gene–environment interaction has not been evaluated.Methods.We examined whether family history of psychosis (FHP) and parental SES may predict PA and AAO in unrelated cases with first-episode psychosis (n = 108) and schizophrenia (n = 104). Premorbid academic and social functioning domains during childhood and early adolescence were retrospectively assessed. Regression analyses were performed to investigate main effects of FHP and parental SES, as well as their interaction. The relationships between PA, AAO, and response to antipsychotic medication were also explored.Results.Positive FHP associated with academic PA difficulties and importantly interacted with parental SES to moderate social PA during childhood (interaction p = 0.024). Positive FHP and parental SES did not predict differences in AAO. Nevertheless, an earlier AAO was observed among cases with worse social PA in childhood (β = −0.20; p = 0.005) and early adolescence (β = −0.19; p = 0.007). Further, confirming evidence emerged for an association between deficient childhood social PA and poor treatment response (p = 0.04).Conclusions.Familial risk for psychosis may interact with parental socioeconomic position influencing social PA in childhood. In addition, this study supports the link between social PA deviations, early psychosis onset, and treatment resistance, which highlights premorbid social functioning as a promising clinical indicator. |
| first_indexed | 2024-04-10T04:50:01Z |
| format | Article |
| id | doaj.art-fee7d02c6d394fe8b2627e52024d10d7 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-04-10T04:50:01Z |
| publishDate | 2020-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-fee7d02c6d394fe8b2627e52024d10d72023-03-09T12:33:57ZengCambridge University PressEuropean Psychiatry0924-93381778-35852020-01-016310.1192/j.eurpsy.2020.41Familial and socioeconomic contributions to premorbid functioning in psychosis: Impact on age at onset and treatment responseAlex Hatzimanolis0Pentagiotissa Stefanatou1https://orcid.org/0000-0002-7552-3901Emmanouil Kattoulas2Irene Ralli3Stefanos Dimitrakopoulos4Stefania Foteli5Ioannis Kosteletos6Leonidas Mantonakis7Mirjana Selakovic8Rigas-Filippos Soldatos9https://orcid.org/0000-0001-8337-5366Ilias Vlachos10Lida-Alkisti Xenaki11Nikolaos Smyrnis12Nicholas C. Stefanis13Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, Greece Neurobiology Research Institute, Theodor-Theohari Cozzika Foundation, 11521 Athens, GreeceDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, GreeceDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, GreeceDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, GreeceDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, GreeceDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, GreeceDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, GreeceDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, GreeceDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, GreeceDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, GreeceDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, GreeceDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, GreeceDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, Greece University Mental Health, Neurosciences and Precision Medicine Research Institute, 11527 Athens, GreeceDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 11528 Athens, Greece Neurobiology Research Institute, Theodor-Theohari Cozzika Foundation, 11521 Athens, Greece University Mental Health, Neurosciences and Precision Medicine Research Institute, 11527 Athens, GreeceAbstractBackground.Premorbid adjustment (PA) abnormalities in psychotic disorders are associated with an earlier age at onset (AAO) and unfavorable clinical outcomes, including treatment resistance. Prior family studies suggest that familial liability, likely reflecting increased genetic risk, and socioeconomic status (SES) contribute to premorbid maladjustment. However, their joint effect possibly indicating gene–environment interaction has not been evaluated.Methods.We examined whether family history of psychosis (FHP) and parental SES may predict PA and AAO in unrelated cases with first-episode psychosis (n = 108) and schizophrenia (n = 104). Premorbid academic and social functioning domains during childhood and early adolescence were retrospectively assessed. Regression analyses were performed to investigate main effects of FHP and parental SES, as well as their interaction. The relationships between PA, AAO, and response to antipsychotic medication were also explored.Results.Positive FHP associated with academic PA difficulties and importantly interacted with parental SES to moderate social PA during childhood (interaction p = 0.024). Positive FHP and parental SES did not predict differences in AAO. Nevertheless, an earlier AAO was observed among cases with worse social PA in childhood (β = −0.20; p = 0.005) and early adolescence (β = −0.19; p = 0.007). Further, confirming evidence emerged for an association between deficient childhood social PA and poor treatment response (p = 0.04).Conclusions.Familial risk for psychosis may interact with parental socioeconomic position influencing social PA in childhood. In addition, this study supports the link between social PA deviations, early psychosis onset, and treatment resistance, which highlights premorbid social functioning as a promising clinical indicator.https://www.cambridge.org/core/product/identifier/S0924933820000413/type/journal_articleFamily historyfirst-episode psychosispremorbid adjustmentschizophreniasocioeconomic statustreatment response |
| spellingShingle | Alex Hatzimanolis Pentagiotissa Stefanatou Emmanouil Kattoulas Irene Ralli Stefanos Dimitrakopoulos Stefania Foteli Ioannis Kosteletos Leonidas Mantonakis Mirjana Selakovic Rigas-Filippos Soldatos Ilias Vlachos Lida-Alkisti Xenaki Nikolaos Smyrnis Nicholas C. Stefanis Familial and socioeconomic contributions to premorbid functioning in psychosis: Impact on age at onset and treatment response European Psychiatry Family history first-episode psychosis premorbid adjustment schizophrenia socioeconomic status treatment response |
| title | Familial and socioeconomic contributions to premorbid functioning in psychosis: Impact on age at onset and treatment response |
| title_full | Familial and socioeconomic contributions to premorbid functioning in psychosis: Impact on age at onset and treatment response |
| title_fullStr | Familial and socioeconomic contributions to premorbid functioning in psychosis: Impact on age at onset and treatment response |
| title_full_unstemmed | Familial and socioeconomic contributions to premorbid functioning in psychosis: Impact on age at onset and treatment response |
| title_short | Familial and socioeconomic contributions to premorbid functioning in psychosis: Impact on age at onset and treatment response |
| title_sort | familial and socioeconomic contributions to premorbid functioning in psychosis impact on age at onset and treatment response |
| topic | Family history first-episode psychosis premorbid adjustment schizophrenia socioeconomic status treatment response |
| url | https://www.cambridge.org/core/product/identifier/S0924933820000413/type/journal_article |
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