Study protocol on effectiveness of yoga practice on composite biomarker age predictors (yBioAge) in an elderly Indian cohort- two-armed open label randomized controlled trial
Abstract Introduction The recent development of robust indices to quantify biological aging, along with the dynamic epidemiological transitions of population aging generate the unmet need to examine the extent up to which potential interventions can delay, halt or temporarily modulate aging trajecto...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-023-04517-6 |
| _version_ | 1797388103838597120 |
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| author | Vijaya Majumdar N. K. Manjunath Atmakur Snigdha Prosenjeet Chakraborty Robin Majumdar |
| author_facet | Vijaya Majumdar N. K. Manjunath Atmakur Snigdha Prosenjeet Chakraborty Robin Majumdar |
| author_sort | Vijaya Majumdar |
| collection | DOAJ |
| description | Abstract Introduction The recent development of robust indices to quantify biological aging, along with the dynamic epidemiological transitions of population aging generate the unmet need to examine the extent up to which potential interventions can delay, halt or temporarily modulate aging trajectories. Methods and analysis The study is a two-armed, open label randomised controlled trial. We aim to recruit 166 subjects, aged 60–75 years from the residential communities and old age clubs in Bangalore city, India, who will undergo randomisation into intervention or control arms (1:1). Intervention will include yoga sessions tailored for the older adults, 1 h per day for 5 days a week, spread for 12 months. Data would be collected at the baseline, 26th week and 52nd week. The primary outcome of the study is estimation in biological age with yoga practice. The secondary outcomes will include cardinal mechanistic indicators of aging- telomere length, interleukin-6 (IL-6), tumor necrosis factor receptor II (TNF-RII), high sensitivity c-reactive protein (hsCRP)], insulin signaling [insulin and IGF1], renal function [cystatin], senescence [growth differentiating factor 15 (GDF-15)] and cardiovascular function [N-terminal B-type natriuretic peptides (NT-proBNP)]. Analyses will be by intention-to-treat model. Ethics & dissemination The study is approved by the Institutional Ethics Committee of Swami Vivekananda Yoga Anusandhana Samsthana University, Bangalore (ID:RES/IEC-SVYASA/242/2022). Written informed consent will be obtained from each participant prior to inclusion. Trial registration number CTRI/2022/07/044442. |
| first_indexed | 2024-03-08T22:35:57Z |
| format | Article |
| id | doaj.art-fee7f850d2914473ab7cdf9dbd6d560d |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-03-08T22:35:57Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-fee7f850d2914473ab7cdf9dbd6d560d2023-12-17T12:29:17ZengBMCBMC Geriatrics1471-23182023-12-012311910.1186/s12877-023-04517-6Study protocol on effectiveness of yoga practice on composite biomarker age predictors (yBioAge) in an elderly Indian cohort- two-armed open label randomized controlled trialVijaya Majumdar0N. K. Manjunath1Atmakur Snigdha2Prosenjeet Chakraborty3Robin Majumdar4Division of Life Science, Molecular Bioscience Lab, Swami Vivekananda Yoga Anusandhana SamsthanaDivision of Life Science, Molecular Bioscience Lab, Swami Vivekananda Yoga Anusandhana SamsthanaDivision of Life Science, Molecular Bioscience Lab, Swami Vivekananda Yoga Anusandhana SamsthanaDivision of Life Science, Molecular Bioscience Lab, Swami Vivekananda Yoga Anusandhana SamsthanaIndian Institute of Information TechnologyAbstract Introduction The recent development of robust indices to quantify biological aging, along with the dynamic epidemiological transitions of population aging generate the unmet need to examine the extent up to which potential interventions can delay, halt or temporarily modulate aging trajectories. Methods and analysis The study is a two-armed, open label randomised controlled trial. We aim to recruit 166 subjects, aged 60–75 years from the residential communities and old age clubs in Bangalore city, India, who will undergo randomisation into intervention or control arms (1:1). Intervention will include yoga sessions tailored for the older adults, 1 h per day for 5 days a week, spread for 12 months. Data would be collected at the baseline, 26th week and 52nd week. The primary outcome of the study is estimation in biological age with yoga practice. The secondary outcomes will include cardinal mechanistic indicators of aging- telomere length, interleukin-6 (IL-6), tumor necrosis factor receptor II (TNF-RII), high sensitivity c-reactive protein (hsCRP)], insulin signaling [insulin and IGF1], renal function [cystatin], senescence [growth differentiating factor 15 (GDF-15)] and cardiovascular function [N-terminal B-type natriuretic peptides (NT-proBNP)]. Analyses will be by intention-to-treat model. Ethics & dissemination The study is approved by the Institutional Ethics Committee of Swami Vivekananda Yoga Anusandhana Samsthana University, Bangalore (ID:RES/IEC-SVYASA/242/2022). Written informed consent will be obtained from each participant prior to inclusion. Trial registration number CTRI/2022/07/044442.https://doi.org/10.1186/s12877-023-04517-6Biological ageYogaAging |
| spellingShingle | Vijaya Majumdar N. K. Manjunath Atmakur Snigdha Prosenjeet Chakraborty Robin Majumdar Study protocol on effectiveness of yoga practice on composite biomarker age predictors (yBioAge) in an elderly Indian cohort- two-armed open label randomized controlled trial BMC Geriatrics Biological age Yoga Aging |
| title | Study protocol on effectiveness of yoga practice on composite biomarker age predictors (yBioAge) in an elderly Indian cohort- two-armed open label randomized controlled trial |
| title_full | Study protocol on effectiveness of yoga practice on composite biomarker age predictors (yBioAge) in an elderly Indian cohort- two-armed open label randomized controlled trial |
| title_fullStr | Study protocol on effectiveness of yoga practice on composite biomarker age predictors (yBioAge) in an elderly Indian cohort- two-armed open label randomized controlled trial |
| title_full_unstemmed | Study protocol on effectiveness of yoga practice on composite biomarker age predictors (yBioAge) in an elderly Indian cohort- two-armed open label randomized controlled trial |
| title_short | Study protocol on effectiveness of yoga practice on composite biomarker age predictors (yBioAge) in an elderly Indian cohort- two-armed open label randomized controlled trial |
| title_sort | study protocol on effectiveness of yoga practice on composite biomarker age predictors ybioage in an elderly indian cohort two armed open label randomized controlled trial |
| topic | Biological age Yoga Aging |
| url | https://doi.org/10.1186/s12877-023-04517-6 |
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