Formulation, Physiochemical, and Microbial Assay of Henna Oil Vaginal Suppository Formulated with Polyethylene Glycol Bases
Background: Persian Medicine is one of the oldest and richest complementary and alternative options in the field of medicine and has a comprehensive medical system. Henna oil is recommended in Persian Medicine for the treatment of numerous women’s diseases such as cervicitis. To date, henna has been...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2020-05-01
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| Series: | Iranian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://ijms.sums.ac.ir/article_44965_a220696430d93d0cbdf36d4ffebadb81.pdf |
| _version_ | 1818959472454795264 |
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| author | Payam Khazaeli Mitra Mehrabani Ahmad Mosadegh Soudabeh Bios Rahele Zareshahi Mohammad Hasan Moshafi |
| author_facet | Payam Khazaeli Mitra Mehrabani Ahmad Mosadegh Soudabeh Bios Rahele Zareshahi Mohammad Hasan Moshafi |
| author_sort | Payam Khazaeli |
| collection | DOAJ |
| description | Background: Persian Medicine is one of the oldest and richest complementary and alternative options in the field of medicine and has a comprehensive medical system. Henna oil is recommended in Persian Medicine for the treatment of numerous women’s diseases such as cervicitis. To date, henna has been used for many medical purposes, including astringent, bleeding, cardioinhibitory, hypotension, and relaxation. Accordingly, the present study aimed to provide the formulation of a henna-oil-based vaginal suppository and examine its physicochemical and antimicrobial properties. <br />Methods: The present study was approved and performed in accordance with the regulations of Research Council, Kerman University of Medical Sciences, Kerman, Iran, in July 2016. Different percentages of henna oil, glycerin, and gelatin, as well as henna oil and polyethylene glycol 400 and 4000, were mixed to achieve a formulation with proper appearance features and, particularly, without any oil leakage from the suppository surface. Uniformity of weight, uniformity of content, disintegration time, and dissolution test of the suppositories were evaluated. The growth-inhibiting activity of the suppositories and aqueous extract of henna was evaluated against bacteria, including the Gram-positive bacterium Gardnerella vaginalis, Neisseria gonorrhoeae, and group B streptococcus. <br />Results: The formulations had a smooth appearance without any cracks or fractures. Disintegration times for glycero-gelatin and polyethylene glycol suppositories were 60 and 10 min, respectively. 40% of the drug was released from polyethylene glycol suppositories after 60 min, but glycero-gelatin suppositories had no release after three hours. Minimum inhibitory concentration (MIC) of suppositories and aqueous extract were 0.4 mg/mL and 0.01 mg/mL, respectively. <br />Conclusion: Polyethylene glycol suppositories had acceptable physicochemical properties, and the henna extract and suppositories inhibited the three studied pathogens. |
| first_indexed | 2024-12-20T11:42:11Z |
| format | Article |
| id | doaj.art-fee7fcb448584bc284565df3a628786f |
| institution | Directory Open Access Journal |
| issn | 0253-0716 1735-3688 |
| language | English |
| last_indexed | 2024-12-20T11:42:11Z |
| publishDate | 2020-05-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Sciences |
| spelling | doaj.art-fee7fcb448584bc284565df3a628786f2022-12-21T19:41:58ZengShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-07161735-36882020-05-0145320721310.30476/ijms.2019.4496544965Formulation, Physiochemical, and Microbial Assay of Henna Oil Vaginal Suppository Formulated with Polyethylene Glycol BasesPayam Khazaeli0Mitra Mehrabani1Ahmad Mosadegh2Soudabeh Bios3Rahele Zareshahi4Mohammad Hasan Moshafi5Department of Pharmaceutics, School of Pharmacy, Kerman University of Medical Sciences, Kerman, IranHerbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, IranDepartment of Microbiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Iranian Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Traditional Medicine, School of Traditional Medicine, Kerman University of Medical Sciences, Kerman, IranDepartment of Pharmacology, School of Medicine, Kerman University of Medical Sciences, Kerman, IranBackground: Persian Medicine is one of the oldest and richest complementary and alternative options in the field of medicine and has a comprehensive medical system. Henna oil is recommended in Persian Medicine for the treatment of numerous women’s diseases such as cervicitis. To date, henna has been used for many medical purposes, including astringent, bleeding, cardioinhibitory, hypotension, and relaxation. Accordingly, the present study aimed to provide the formulation of a henna-oil-based vaginal suppository and examine its physicochemical and antimicrobial properties. <br />Methods: The present study was approved and performed in accordance with the regulations of Research Council, Kerman University of Medical Sciences, Kerman, Iran, in July 2016. Different percentages of henna oil, glycerin, and gelatin, as well as henna oil and polyethylene glycol 400 and 4000, were mixed to achieve a formulation with proper appearance features and, particularly, without any oil leakage from the suppository surface. Uniformity of weight, uniformity of content, disintegration time, and dissolution test of the suppositories were evaluated. The growth-inhibiting activity of the suppositories and aqueous extract of henna was evaluated against bacteria, including the Gram-positive bacterium Gardnerella vaginalis, Neisseria gonorrhoeae, and group B streptococcus. <br />Results: The formulations had a smooth appearance without any cracks or fractures. Disintegration times for glycero-gelatin and polyethylene glycol suppositories were 60 and 10 min, respectively. 40% of the drug was released from polyethylene glycol suppositories after 60 min, but glycero-gelatin suppositories had no release after three hours. Minimum inhibitory concentration (MIC) of suppositories and aqueous extract were 0.4 mg/mL and 0.01 mg/mL, respectively. <br />Conclusion: Polyethylene glycol suppositories had acceptable physicochemical properties, and the henna extract and suppositories inhibited the three studied pathogens.http://ijms.sums.ac.ir/article_44965_a220696430d93d0cbdf36d4ffebadb81.pdfhennasuppositoryuterine cervicitispolyethylene glycols |
| spellingShingle | Payam Khazaeli Mitra Mehrabani Ahmad Mosadegh Soudabeh Bios Rahele Zareshahi Mohammad Hasan Moshafi Formulation, Physiochemical, and Microbial Assay of Henna Oil Vaginal Suppository Formulated with Polyethylene Glycol Bases Iranian Journal of Medical Sciences henna suppository uterine cervicitis polyethylene glycols |
| title | Formulation, Physiochemical, and Microbial Assay of Henna Oil Vaginal Suppository Formulated with Polyethylene Glycol Bases |
| title_full | Formulation, Physiochemical, and Microbial Assay of Henna Oil Vaginal Suppository Formulated with Polyethylene Glycol Bases |
| title_fullStr | Formulation, Physiochemical, and Microbial Assay of Henna Oil Vaginal Suppository Formulated with Polyethylene Glycol Bases |
| title_full_unstemmed | Formulation, Physiochemical, and Microbial Assay of Henna Oil Vaginal Suppository Formulated with Polyethylene Glycol Bases |
| title_short | Formulation, Physiochemical, and Microbial Assay of Henna Oil Vaginal Suppository Formulated with Polyethylene Glycol Bases |
| title_sort | formulation physiochemical and microbial assay of henna oil vaginal suppository formulated with polyethylene glycol bases |
| topic | henna suppository uterine cervicitis polyethylene glycols |
| url | http://ijms.sums.ac.ir/article_44965_a220696430d93d0cbdf36d4ffebadb81.pdf |
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