A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression

A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression

Summary: The p53 tumor suppressor exerts antitumor functions through its ability to regulate the transcription of its downstream targets. Long noncoding RNAs (lncRNAs) act as oncogenes or tumor suppressors implicated in tumorigenesis and tumor progression. Here, we identify the lncRNA LINC00324 (lon...

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Bibliographic Details
Main Authors: Ling Zhang, Jun Zhang, Xiaofeng Xuan, Di Wu, Jianfeng Yu, Peizhen Wang, Xiaomei Yang, Jieru Zhang, Wenjuan Gan, Mengfan He, Xiao-Min Liu, Jun Zhou, Donglai Wang, Wei Gu, Dawei Li
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723008446

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