Lipidomics of Bioactive Lipids in Alzheimer’s and Parkinson’s Diseases: Where Are We?
Lipids are not only constituents of cellular membranes, but they are also key signaling mediators, thus acting as “bioactive lipids”. Among the prominent roles exerted by bioactive lipids are immune regulation, inflammation, and maintenance of homeostasis. Accumulated evidence indicates the existenc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/11/6235 |
| _version_ | 1797493071357673472 |
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| author | Valerio Chiurchiù Marta Tiberi Alessandro Matteocci Federico Fazio Hasibullah Siffeti Stefano Saracini Nicola Biagio Mercuri Giuseppe Sancesario |
| author_facet | Valerio Chiurchiù Marta Tiberi Alessandro Matteocci Federico Fazio Hasibullah Siffeti Stefano Saracini Nicola Biagio Mercuri Giuseppe Sancesario |
| author_sort | Valerio Chiurchiù |
| collection | DOAJ |
| description | Lipids are not only constituents of cellular membranes, but they are also key signaling mediators, thus acting as “bioactive lipids”. Among the prominent roles exerted by bioactive lipids are immune regulation, inflammation, and maintenance of homeostasis. Accumulated evidence indicates the existence of a bidirectional relationship between the immune and nervous systems, and lipids can interact particularly with the aggregation and propagation of many pathogenic proteins that are well-renowned hallmarks of several neurodegenerative disorders, including Alzheimer’s (AD) and Parkinson’s (PD) diseases. In this review, we summarize the current knowledge about the presence and quantification of the main classes of endogenous bioactive lipids, namely glycerophospholipids/sphingolipids, classical eicosanoids, pro-resolving lipid mediators, and endocannabinoids, in AD and PD patients, as well as their most-used animal models, by means of lipidomic analyses, advocating for these lipid mediators as powerful biomarkers of pathology, diagnosis, and progression, as well as predictors of response or activity to different current therapies for these neurodegenerative diseases. |
| first_indexed | 2024-03-10T01:14:44Z |
| format | Article |
| id | doaj.art-fee9c46fceb8466e9e4a3108665ca0d0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:14:44Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fee9c46fceb8466e9e4a3108665ca0d02023-11-23T14:12:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012311623510.3390/ijms23116235Lipidomics of Bioactive Lipids in Alzheimer’s and Parkinson’s Diseases: Where Are We?Valerio Chiurchiù0Marta Tiberi1Alessandro Matteocci2Federico Fazio3Hasibullah Siffeti4Stefano Saracini5Nicola Biagio Mercuri6Giuseppe Sancesario7Institute of Translational Pharmacology, National Research Council, 00179 Rome, ItalyLaboratory of Resolution of Neuroinflammation, IRCCS Santa Lucia Foundation, 00179 Rome, ItalyLaboratory of Resolution of Neuroinflammation, IRCCS Santa Lucia Foundation, 00179 Rome, ItalyLaboratory of Resolution of Neuroinflammation, IRCCS Santa Lucia Foundation, 00179 Rome, ItalyLaboratory of Resolution of Neuroinflammation, IRCCS Santa Lucia Foundation, 00179 Rome, ItalyLaboratory of Resolution of Neuroinflammation, IRCCS Santa Lucia Foundation, 00179 Rome, ItalyNeurology Unit, Tor Vergata Hospital, 00133 Rome, ItalyDepartment of Systems Medicine, Tor Vergata University of Rome, 00179 Rome, ItalyLipids are not only constituents of cellular membranes, but they are also key signaling mediators, thus acting as “bioactive lipids”. Among the prominent roles exerted by bioactive lipids are immune regulation, inflammation, and maintenance of homeostasis. Accumulated evidence indicates the existence of a bidirectional relationship between the immune and nervous systems, and lipids can interact particularly with the aggregation and propagation of many pathogenic proteins that are well-renowned hallmarks of several neurodegenerative disorders, including Alzheimer’s (AD) and Parkinson’s (PD) diseases. In this review, we summarize the current knowledge about the presence and quantification of the main classes of endogenous bioactive lipids, namely glycerophospholipids/sphingolipids, classical eicosanoids, pro-resolving lipid mediators, and endocannabinoids, in AD and PD patients, as well as their most-used animal models, by means of lipidomic analyses, advocating for these lipid mediators as powerful biomarkers of pathology, diagnosis, and progression, as well as predictors of response or activity to different current therapies for these neurodegenerative diseases.https://www.mdpi.com/1422-0067/23/11/6235glycerophospholipidssphingolipidsclassical eicosanoidsspecialized pro-resolving mediatorsendocannabinoidsAlzheimer’s |
| spellingShingle | Valerio Chiurchiù Marta Tiberi Alessandro Matteocci Federico Fazio Hasibullah Siffeti Stefano Saracini Nicola Biagio Mercuri Giuseppe Sancesario Lipidomics of Bioactive Lipids in Alzheimer’s and Parkinson’s Diseases: Where Are We? International Journal of Molecular Sciences glycerophospholipids sphingolipids classical eicosanoids specialized pro-resolving mediators endocannabinoids Alzheimer’s |
| title | Lipidomics of Bioactive Lipids in Alzheimer’s and Parkinson’s Diseases: Where Are We? |
| title_full | Lipidomics of Bioactive Lipids in Alzheimer’s and Parkinson’s Diseases: Where Are We? |
| title_fullStr | Lipidomics of Bioactive Lipids in Alzheimer’s and Parkinson’s Diseases: Where Are We? |
| title_full_unstemmed | Lipidomics of Bioactive Lipids in Alzheimer’s and Parkinson’s Diseases: Where Are We? |
| title_short | Lipidomics of Bioactive Lipids in Alzheimer’s and Parkinson’s Diseases: Where Are We? |
| title_sort | lipidomics of bioactive lipids in alzheimer s and parkinson s diseases where are we |
| topic | glycerophospholipids sphingolipids classical eicosanoids specialized pro-resolving mediators endocannabinoids Alzheimer’s |
| url | https://www.mdpi.com/1422-0067/23/11/6235 |
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