Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy
Histamine receptor antagonists, which can bind to specific histamine receptors on target cells, exhibit substantial therapeutic efficacy in managing a variety of histamine-mediated disorders. Notably, histamine H1 and H2 receptor antagonists have been extensively investigated and universally acknowl...
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MDPI AG
2024-01-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/14/2/164 |
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| author | Erwen Kou Xiaobei Zhang Baiping Dong Bo Wang Yuanjie Zhu |
| author_facet | Erwen Kou Xiaobei Zhang Baiping Dong Bo Wang Yuanjie Zhu |
| author_sort | Erwen Kou |
| collection | DOAJ |
| description | Histamine receptor antagonists, which can bind to specific histamine receptors on target cells, exhibit substantial therapeutic efficacy in managing a variety of histamine-mediated disorders. Notably, histamine H1 and H2 receptor antagonists have been extensively investigated and universally acknowledged as recommended treatment agents for numerous allergic diseases and acid-related disorders, respectively. Historically, the combination of H1 and H2 receptor antagonists has been considered a classic treatment strategy, demonstrating relatively superior efficacy compared with single-drug therapies in the treatment of diverse histamine-mediated diseases. The latest emerging studies have additionally suggested the underlying roles of histamine and H1R and H2R in the development of anxiety disorders, arthritic diseases, and postexercise hypotension. Nevertheless, there is still a lack of systematic reviews on the clinical efficacy of combination therapy, greatly limiting our understanding of its clinical application. Here, we present a comprehensive overview of the current knowledge and perspectives regarding the combination of H1 and H2 histamine receptor antagonists in various histamine-mediated disorders. Furthermore, we critically analyze the adverse effects and limitations associated with combination therapy while suggesting potential solutions. Our review can offer a systematic summary and promising insights into the in-depth and effective application of the combination of H1 and H2 receptor antagonists. |
| first_indexed | 2024-03-07T22:25:19Z |
| format | Article |
| id | doaj.art-feebc271fea046d8b02b536d7ecdf7aa |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-07T22:25:19Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-feebc271fea046d8b02b536d7ecdf7aa2024-02-23T15:24:30ZengMDPI AGLife2075-17292024-01-0114216410.3390/life14020164Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment StrategyErwen Kou0Xiaobei Zhang1Baiping Dong2Bo Wang3Yuanjie Zhu4Department of Dermatology, Naval Medical Center, Naval Medical University, Shanghai 200052, ChinaDepartment of Pharmacy, Naval Medical Center, Naval Medical University, Shanghai 200052, ChinaDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai 200052, ChinaDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai 200052, ChinaDepartment of Dermatology, Naval Medical Center, Naval Medical University, Shanghai 200052, ChinaHistamine receptor antagonists, which can bind to specific histamine receptors on target cells, exhibit substantial therapeutic efficacy in managing a variety of histamine-mediated disorders. Notably, histamine H1 and H2 receptor antagonists have been extensively investigated and universally acknowledged as recommended treatment agents for numerous allergic diseases and acid-related disorders, respectively. Historically, the combination of H1 and H2 receptor antagonists has been considered a classic treatment strategy, demonstrating relatively superior efficacy compared with single-drug therapies in the treatment of diverse histamine-mediated diseases. The latest emerging studies have additionally suggested the underlying roles of histamine and H1R and H2R in the development of anxiety disorders, arthritic diseases, and postexercise hypotension. Nevertheless, there is still a lack of systematic reviews on the clinical efficacy of combination therapy, greatly limiting our understanding of its clinical application. Here, we present a comprehensive overview of the current knowledge and perspectives regarding the combination of H1 and H2 histamine receptor antagonists in various histamine-mediated disorders. Furthermore, we critically analyze the adverse effects and limitations associated with combination therapy while suggesting potential solutions. Our review can offer a systematic summary and promising insights into the in-depth and effective application of the combination of H1 and H2 receptor antagonists.https://www.mdpi.com/2075-1729/14/2/164histaminehistamine receptor antagonistscombination therapyH1 receptorH2 receptorhistamine-mediated diseases |
| spellingShingle | Erwen Kou Xiaobei Zhang Baiping Dong Bo Wang Yuanjie Zhu Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy Life histamine histamine receptor antagonists combination therapy H1 receptor H2 receptor histamine-mediated diseases |
| title | Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy |
| title_full | Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy |
| title_fullStr | Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy |
| title_full_unstemmed | Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy |
| title_short | Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy |
| title_sort | combination of h1 and h2 histamine receptor antagonists current knowledge and perspectives of a classic treatment strategy |
| topic | histamine histamine receptor antagonists combination therapy H1 receptor H2 receptor histamine-mediated diseases |
| url | https://www.mdpi.com/2075-1729/14/2/164 |
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