Pancreas transplant with enteric drainage at a single institute in Asia
Summary: Background/objective: This study is to assess immunological and graft survival outcomes after pancreas transplant at a single institute in Asia. Methods: Patients undergoing pancreas transplant with enteric drainage were included. Clinical data and outcomes were evaluated and compared betw...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Asian Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958421004164 |
| _version_ | 1818999886695104512 |
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| author | Mu-Shan Shih Bor-Uei Shyr Bor-Shiuan Shyr Shih-Chin Chen Yi-Ming Shyr Shin-E Wang |
| author_facet | Mu-Shan Shih Bor-Uei Shyr Bor-Shiuan Shyr Shih-Chin Chen Yi-Ming Shyr Shin-E Wang |
| author_sort | Mu-Shan Shih |
| collection | DOAJ |
| description | Summary: Background/objective: This study is to assess immunological and graft survival outcomes after pancreas transplant at a single institute in Asia. Methods: Patients undergoing pancreas transplant with enteric drainage were included. Clinical data and outcomes were evaluated and compared between each subgroup. Results: There were 165 cases of pancreas transplant, including 38 (23 %) simultaneous pancreas-kidney transplant (SPK), 24 (15 %) pancreas after kidney transplant (PAK), 75 (46 %) pancreas transplant alone (PTA), and 28 (17 %) pancreas before kidney transplant (PBK). The overall surgical complication rate was 46.1 %, with highest (62.5 %) in PAK and lowest (32.0 %) in PTA, P = 0.008. The late complications included 32.7 % infection and 3.6 % malignancy. Overall rejection of pancreas graft was 24.8 % including 18.2 % acute and 9.7 % chronic rejection. Rejection was highest in PTA group (36.0 %) and lowest in PBK (3.6 %). There were 56 cases (33.9 %) with graft loss in total, with highest graft loss rate in PTA (38.7 %). The 1-year, 5-year and 10-year pancreas graft survivals for total patients were 98.0 %, 87.7 % and 70.9 % respectively. Conclusions: Enteric drainage in pancreas transplant could be applied safely not only in SPK but also in other subgroups. Enteric drainage itself would not compromise the immunological and graft survival outcomes. |
| first_indexed | 2024-12-20T22:24:33Z |
| format | Article |
| id | doaj.art-feed1e7be1484646b03d2c675d06ea21 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-20T22:24:33Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-feed1e7be1484646b03d2c675d06ea212022-12-21T19:24:51ZengElsevierAsian Journal of Surgery1015-95842022-01-01451412418Pancreas transplant with enteric drainage at a single institute in AsiaMu-Shan Shih0Bor-Uei Shyr1Bor-Shiuan Shyr2Shih-Chin Chen3Yi-Ming Shyr4Shin-E Wang5Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROCDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROCDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROCDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROCDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROCCorresponding author. Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, 201 Section 2 Shipai Road, Taipei, 112, Taiwan.; Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROCSummary: Background/objective: This study is to assess immunological and graft survival outcomes after pancreas transplant at a single institute in Asia. Methods: Patients undergoing pancreas transplant with enteric drainage were included. Clinical data and outcomes were evaluated and compared between each subgroup. Results: There were 165 cases of pancreas transplant, including 38 (23 %) simultaneous pancreas-kidney transplant (SPK), 24 (15 %) pancreas after kidney transplant (PAK), 75 (46 %) pancreas transplant alone (PTA), and 28 (17 %) pancreas before kidney transplant (PBK). The overall surgical complication rate was 46.1 %, with highest (62.5 %) in PAK and lowest (32.0 %) in PTA, P = 0.008. The late complications included 32.7 % infection and 3.6 % malignancy. Overall rejection of pancreas graft was 24.8 % including 18.2 % acute and 9.7 % chronic rejection. Rejection was highest in PTA group (36.0 %) and lowest in PBK (3.6 %). There were 56 cases (33.9 %) with graft loss in total, with highest graft loss rate in PTA (38.7 %). The 1-year, 5-year and 10-year pancreas graft survivals for total patients were 98.0 %, 87.7 % and 70.9 % respectively. Conclusions: Enteric drainage in pancreas transplant could be applied safely not only in SPK but also in other subgroups. Enteric drainage itself would not compromise the immunological and graft survival outcomes.http://www.sciencedirect.com/science/article/pii/S1015958421004164Pancreas before kidney transplant (PBK)Pancreas after kidney transplant (PAK)Simultaneous kidney pancreas transplant (SPK)Pancreas transplant alone (PTA) |
| spellingShingle | Mu-Shan Shih Bor-Uei Shyr Bor-Shiuan Shyr Shih-Chin Chen Yi-Ming Shyr Shin-E Wang Pancreas transplant with enteric drainage at a single institute in Asia Asian Journal of Surgery Pancreas before kidney transplant (PBK) Pancreas after kidney transplant (PAK) Simultaneous kidney pancreas transplant (SPK) Pancreas transplant alone (PTA) |
| title | Pancreas transplant with enteric drainage at a single institute in Asia |
| title_full | Pancreas transplant with enteric drainage at a single institute in Asia |
| title_fullStr | Pancreas transplant with enteric drainage at a single institute in Asia |
| title_full_unstemmed | Pancreas transplant with enteric drainage at a single institute in Asia |
| title_short | Pancreas transplant with enteric drainage at a single institute in Asia |
| title_sort | pancreas transplant with enteric drainage at a single institute in asia |
| topic | Pancreas before kidney transplant (PBK) Pancreas after kidney transplant (PAK) Simultaneous kidney pancreas transplant (SPK) Pancreas transplant alone (PTA) |
| url | http://www.sciencedirect.com/science/article/pii/S1015958421004164 |
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