Comparative evaluation of bovine derived hydroxyapatite and synthetic hydroxyapatite graft in bone regeneration of human maxillary cystic defects: A clinico-radiological study
Introduction: Bone grafts are frequently used in the treatment of bone defects. Bone harvesting can cause postoperative complications and sometimes does not provide a sufficient quantity of bone. Therefore, synthetic biomaterials have been investigated as an alternative to autogenous bone grafts. A...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-01-01
|
| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | http://www.ijdr.in/article.asp?issn=0970-9290;year=2014;volume=25;issue=5;spage=594;epage=601;aulast=Kattimani |
| _version_ | 1811333489907204096 |
|---|---|
| author | Vivekanand S Kattimani Srinivas P Chakravarthi K Naga Neelima Devi Meka S Sridhar L Krishna Prasad |
| author_facet | Vivekanand S Kattimani Srinivas P Chakravarthi K Naga Neelima Devi Meka S Sridhar L Krishna Prasad |
| author_sort | Vivekanand S Kattimani |
| collection | DOAJ |
| description | Introduction: Bone grafts are frequently used in the treatment of bone defects. Bone harvesting can cause postoperative complications and sometimes does not provide a sufficient quantity of bone. Therefore, synthetic biomaterials have been investigated as an alternative to autogenous bone grafts.
Aim and Objectives: The aim of this study was to evaluate and compare bovine derived hydroxyapatite (BHA) and synthetic hydroxyapatite (SHA) graft material as bone graft substitute in maxillary cystic bony defects. Patients were analyzed by computerized densitometric study and digital radiography.
Materials and Methods: In this study, 12 patients in each group were included randomly after clinical and radiological evaluation. The integration of hydroxyapatite was assessed with mean bone density, surgical site margin, and radiological bone formation characteristics, of the successful graft cases using computer densitometry and radio-visiograph. Statistical analysis was carried out using Mann-Whitney U-test, Wilcoxon matched pairs test and paired t-test.
Results: By the end of 24 th week, the grafted defects radiologically and statistically showed similar volumes of bone formation. However, the significant changes observed in the formation of bone and merging of material and surgical site margin at 1 st week to 1 st month. The results were significant and correlating with all the parameters showing the necessity of the grafting for early bone formation. However, the bone formation pattern is different in both BHA and SHA group at 3 rd month interval with significant P value.
Conclusion: Both BHA and SHA graft materials are biocompatible for filling bone defects, showing less resorption and enhanced bone formation with similar efficacy. Our study showed maximum bone healing within 12 weeks of grafting of defects. The BHA is economical; however, price difference between the two is very nominal. |
| first_indexed | 2024-04-13T16:52:34Z |
| format | Article |
| id | doaj.art-feee658d5bc045bb99ebc3ae27592e55 |
| institution | Directory Open Access Journal |
| issn | 0970-9290 1998-3603 |
| language | English |
| last_indexed | 2024-04-13T16:52:34Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj.art-feee658d5bc045bb99ebc3ae27592e552022-12-22T02:38:54ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032014-01-0125559460110.4103/0970-9290.147100Comparative evaluation of bovine derived hydroxyapatite and synthetic hydroxyapatite graft in bone regeneration of human maxillary cystic defects: A clinico-radiological studyVivekanand S KattimaniSrinivas P ChakravarthiK Naga Neelima DeviMeka S SridharL Krishna PrasadIntroduction: Bone grafts are frequently used in the treatment of bone defects. Bone harvesting can cause postoperative complications and sometimes does not provide a sufficient quantity of bone. Therefore, synthetic biomaterials have been investigated as an alternative to autogenous bone grafts. Aim and Objectives: The aim of this study was to evaluate and compare bovine derived hydroxyapatite (BHA) and synthetic hydroxyapatite (SHA) graft material as bone graft substitute in maxillary cystic bony defects. Patients were analyzed by computerized densitometric study and digital radiography. Materials and Methods: In this study, 12 patients in each group were included randomly after clinical and radiological evaluation. The integration of hydroxyapatite was assessed with mean bone density, surgical site margin, and radiological bone formation characteristics, of the successful graft cases using computer densitometry and radio-visiograph. Statistical analysis was carried out using Mann-Whitney U-test, Wilcoxon matched pairs test and paired t-test. Results: By the end of 24 th week, the grafted defects radiologically and statistically showed similar volumes of bone formation. However, the significant changes observed in the formation of bone and merging of material and surgical site margin at 1 st week to 1 st month. The results were significant and correlating with all the parameters showing the necessity of the grafting for early bone formation. However, the bone formation pattern is different in both BHA and SHA group at 3 rd month interval with significant P value. Conclusion: Both BHA and SHA graft materials are biocompatible for filling bone defects, showing less resorption and enhanced bone formation with similar efficacy. Our study showed maximum bone healing within 12 weeks of grafting of defects. The BHA is economical; however, price difference between the two is very nominal.http://www.ijdr.in/article.asp?issn=0970-9290;year=2014;volume=25;issue=5;spage=594;epage=601;aulast=Kattimanibone graftbone regenerationbovine derived hydroxyapatitedensitometrydental radio-visiographyobserver strategy for bone healingsynthetic hydroxyapatite |
| spellingShingle | Vivekanand S Kattimani Srinivas P Chakravarthi K Naga Neelima Devi Meka S Sridhar L Krishna Prasad Comparative evaluation of bovine derived hydroxyapatite and synthetic hydroxyapatite graft in bone regeneration of human maxillary cystic defects: A clinico-radiological study Indian Journal of Dental Research bone graft bone regeneration bovine derived hydroxyapatite densitometry dental radio-visiography observer strategy for bone healing synthetic hydroxyapatite |
| title | Comparative evaluation of bovine derived hydroxyapatite and synthetic hydroxyapatite graft in bone regeneration of human maxillary cystic defects: A clinico-radiological study |
| title_full | Comparative evaluation of bovine derived hydroxyapatite and synthetic hydroxyapatite graft in bone regeneration of human maxillary cystic defects: A clinico-radiological study |
| title_fullStr | Comparative evaluation of bovine derived hydroxyapatite and synthetic hydroxyapatite graft in bone regeneration of human maxillary cystic defects: A clinico-radiological study |
| title_full_unstemmed | Comparative evaluation of bovine derived hydroxyapatite and synthetic hydroxyapatite graft in bone regeneration of human maxillary cystic defects: A clinico-radiological study |
| title_short | Comparative evaluation of bovine derived hydroxyapatite and synthetic hydroxyapatite graft in bone regeneration of human maxillary cystic defects: A clinico-radiological study |
| title_sort | comparative evaluation of bovine derived hydroxyapatite and synthetic hydroxyapatite graft in bone regeneration of human maxillary cystic defects a clinico radiological study |
| topic | bone graft bone regeneration bovine derived hydroxyapatite densitometry dental radio-visiography observer strategy for bone healing synthetic hydroxyapatite |
| url | http://www.ijdr.in/article.asp?issn=0970-9290;year=2014;volume=25;issue=5;spage=594;epage=601;aulast=Kattimani |
| work_keys_str_mv | AT vivekanandskattimani comparativeevaluationofbovinederivedhydroxyapatiteandsynthetichydroxyapatitegraftinboneregenerationofhumanmaxillarycysticdefectsaclinicoradiologicalstudy AT srinivaspchakravarthi comparativeevaluationofbovinederivedhydroxyapatiteandsynthetichydroxyapatitegraftinboneregenerationofhumanmaxillarycysticdefectsaclinicoradiologicalstudy AT knaganeelimadevi comparativeevaluationofbovinederivedhydroxyapatiteandsynthetichydroxyapatitegraftinboneregenerationofhumanmaxillarycysticdefectsaclinicoradiologicalstudy AT mekassridhar comparativeevaluationofbovinederivedhydroxyapatiteandsynthetichydroxyapatitegraftinboneregenerationofhumanmaxillarycysticdefectsaclinicoradiologicalstudy AT lkrishnaprasad comparativeevaluationofbovinederivedhydroxyapatiteandsynthetichydroxyapatitegraftinboneregenerationofhumanmaxillarycysticdefectsaclinicoradiologicalstudy |