Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies
One of the regulated forms of cell death is the cell-in-cell (CIC) structure, in which a surviving cell is engulfed by another cell, a mechanism that causes the death of the engulfed cell by an adjacent cell. Several investigators have previously shown that the presence of CICs is an independent ris...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1248097/full |
| _version_ | 1827814850507571200 |
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| author | Kohei Okuyama Kohei Okuyama Kohei Okuyama Hiromasa Fukushima Tomofumi Naruse Souichi Yanamoto |
| author_facet | Kohei Okuyama Kohei Okuyama Kohei Okuyama Hiromasa Fukushima Tomofumi Naruse Souichi Yanamoto |
| author_sort | Kohei Okuyama |
| collection | DOAJ |
| description | One of the regulated forms of cell death is the cell-in-cell (CIC) structure, in which a surviving cell is engulfed by another cell, a mechanism that causes the death of the engulfed cell by an adjacent cell. Several investigators have previously shown that the presence of CICs is an independent risk factor significantly associated with decreased survival in patients with various types of cancer. In this review, we summarize the role of CIC in the tumor microenvironment (TME), including changes and crosstalk of molecules and proteins in the surrounding CIC, and the role of these factors in contributing to therapeutic resistance acquisition. Moreover, CIC structure formation is influenced by the modulation of TME, which may lead to changes in cellular properties. Future use of CIC as a clinical diagnostic tool will require a better understanding of the effects of chemotherapy on CIC, biomarkers for each CIC formation process, and the development of automated CIC detection methods in tissue sections of tumor specimens. |
| first_indexed | 2024-03-11T23:51:44Z |
| format | Article |
| id | doaj.art-feef16d5e80746caac23054c6fef60a3 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-11T23:51:44Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-feef16d5e80746caac23054c6fef60a32023-09-19T07:14:57ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-09-011310.3389/fonc.2023.12480971248097Cell-in-cell structure in cancer: evading strategies from anti-cancer therapiesKohei Okuyama0Kohei Okuyama1Kohei Okuyama2Hiromasa Fukushima3Tomofumi Naruse4Souichi Yanamoto5Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, United StatesRogel Cancer Center, University of Michigan, Ann Arbor, MI, United StatesDepartment of Oral and Maxillofacial Surgical Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, JapanDepartment of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, JapanDepartment of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanOne of the regulated forms of cell death is the cell-in-cell (CIC) structure, in which a surviving cell is engulfed by another cell, a mechanism that causes the death of the engulfed cell by an adjacent cell. Several investigators have previously shown that the presence of CICs is an independent risk factor significantly associated with decreased survival in patients with various types of cancer. In this review, we summarize the role of CIC in the tumor microenvironment (TME), including changes and crosstalk of molecules and proteins in the surrounding CIC, and the role of these factors in contributing to therapeutic resistance acquisition. Moreover, CIC structure formation is influenced by the modulation of TME, which may lead to changes in cellular properties. Future use of CIC as a clinical diagnostic tool will require a better understanding of the effects of chemotherapy on CIC, biomarkers for each CIC formation process, and the development of automated CIC detection methods in tissue sections of tumor specimens.https://www.frontiersin.org/articles/10.3389/fonc.2023.1248097/fullcell-in-cell structureentosisphagocytosischemotherapytargeted therapyradiotherapy |
| spellingShingle | Kohei Okuyama Kohei Okuyama Kohei Okuyama Hiromasa Fukushima Tomofumi Naruse Souichi Yanamoto Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies Frontiers in Oncology cell-in-cell structure entosis phagocytosis chemotherapy targeted therapy radiotherapy |
| title | Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies |
| title_full | Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies |
| title_fullStr | Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies |
| title_full_unstemmed | Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies |
| title_short | Cell-in-cell structure in cancer: evading strategies from anti-cancer therapies |
| title_sort | cell in cell structure in cancer evading strategies from anti cancer therapies |
| topic | cell-in-cell structure entosis phagocytosis chemotherapy targeted therapy radiotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1248097/full |
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