Roles of Non-Coding RNAs in Primary Biliary Cholangitis
Primary biliary cholangitis (PBC) is an autoimmune-mediated chronic cholestatic liver disease, fatigue, and skin itching are the most common clinical symptoms. Its main pathological feature is the progressive damage and destruction of bile duct epithelial cells. Non-coding RNA (NcRNA, mainly includi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.915993/full |
| _version_ | 1818114795671388160 |
|---|---|
| author | Yaqin Zhang Ziying Jiao Mingwei Chen Bing Shen Zongwen Shuai |
| author_facet | Yaqin Zhang Ziying Jiao Mingwei Chen Bing Shen Zongwen Shuai |
| author_sort | Yaqin Zhang |
| collection | DOAJ |
| description | Primary biliary cholangitis (PBC) is an autoimmune-mediated chronic cholestatic liver disease, fatigue, and skin itching are the most common clinical symptoms. Its main pathological feature is the progressive damage and destruction of bile duct epithelial cells. Non-coding RNA (NcRNA, mainly including microRNA, long non-coding RNA and circular RNA) plays a role in the pathological and biological processes of various diseases, especially autoimmune diseases. Many validated ncRNAs are expected to be biomarkers for the diagnosis or treatment of PBC. This review will elucidate the pathogenesis of PBC and help to identify potential ncRNA biomarkers for PBC. |
| first_indexed | 2024-12-11T03:56:24Z |
| format | Article |
| id | doaj.art-feef2b70ea92416981964034f952993d |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-11T03:56:24Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-feef2b70ea92416981964034f952993d2022-12-22T01:21:47ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-07-01910.3389/fmolb.2022.915993915993Roles of Non-Coding RNAs in Primary Biliary CholangitisYaqin Zhang0Ziying Jiao1Mingwei Chen2Bing Shen3Zongwen Shuai4Department of Rheumatology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Physiology, School of Basic Medicine of Anhui Medical University, Hefei, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Physiology, School of Basic Medicine of Anhui Medical University, Hefei, ChinaDepartment of Rheumatology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaPrimary biliary cholangitis (PBC) is an autoimmune-mediated chronic cholestatic liver disease, fatigue, and skin itching are the most common clinical symptoms. Its main pathological feature is the progressive damage and destruction of bile duct epithelial cells. Non-coding RNA (NcRNA, mainly including microRNA, long non-coding RNA and circular RNA) plays a role in the pathological and biological processes of various diseases, especially autoimmune diseases. Many validated ncRNAs are expected to be biomarkers for the diagnosis or treatment of PBC. This review will elucidate the pathogenesis of PBC and help to identify potential ncRNA biomarkers for PBC.https://www.frontiersin.org/articles/10.3389/fmolb.2022.915993/fullprimary biliary cholangitisnon-coding RNAautoimmunityursodeoxycholic acidbiomarker |
| spellingShingle | Yaqin Zhang Ziying Jiao Mingwei Chen Bing Shen Zongwen Shuai Roles of Non-Coding RNAs in Primary Biliary Cholangitis Frontiers in Molecular Biosciences primary biliary cholangitis non-coding RNA autoimmunity ursodeoxycholic acid biomarker |
| title | Roles of Non-Coding RNAs in Primary Biliary Cholangitis |
| title_full | Roles of Non-Coding RNAs in Primary Biliary Cholangitis |
| title_fullStr | Roles of Non-Coding RNAs in Primary Biliary Cholangitis |
| title_full_unstemmed | Roles of Non-Coding RNAs in Primary Biliary Cholangitis |
| title_short | Roles of Non-Coding RNAs in Primary Biliary Cholangitis |
| title_sort | roles of non coding rnas in primary biliary cholangitis |
| topic | primary biliary cholangitis non-coding RNA autoimmunity ursodeoxycholic acid biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.915993/full |
| work_keys_str_mv | AT yaqinzhang rolesofnoncodingrnasinprimarybiliarycholangitis AT ziyingjiao rolesofnoncodingrnasinprimarybiliarycholangitis AT mingweichen rolesofnoncodingrnasinprimarybiliarycholangitis AT bingshen rolesofnoncodingrnasinprimarybiliarycholangitis AT zongwenshuai rolesofnoncodingrnasinprimarybiliarycholangitis |