Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical Outcome
Previous investigations have reported on the motor benefits and safety of chronic extradural motor cortex stimulation (EMCS) for patients with Parkinson’s disease (PD), but studies addressing the long-term clinical outcome are still lacking. In this study, nine consecutive PD patients who underwent...
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MDPI AG
2021-03-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/4/416 |
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| author | Carla Piano Francesco Bove Delia Mulas Enrico Di Stasio Alfonso Fasano Anna Rita Bentivoglio Antonio Daniele Beatrice Cioni Paolo Calabresi Tommaso Tufo |
| author_facet | Carla Piano Francesco Bove Delia Mulas Enrico Di Stasio Alfonso Fasano Anna Rita Bentivoglio Antonio Daniele Beatrice Cioni Paolo Calabresi Tommaso Tufo |
| author_sort | Carla Piano |
| collection | DOAJ |
| description | Previous investigations have reported on the motor benefits and safety of chronic extradural motor cortex stimulation (EMCS) for patients with Parkinson’s disease (PD), but studies addressing the long-term clinical outcome are still lacking. In this study, nine consecutive PD patients who underwent EMCS were prospectively recruited, with a mean follow-up time of 5.1 ± 2.5 years. As compared to the preoperatory baseline, the Unified Parkinson’s Disease Rating Scale (UPDRS)-III in the off-medication condition significantly decreased by 13.8% at 12 months, 16.1% at 18 months, 18.4% at 24 months, 21% at 36 months, 15.6% at 60 months, and 8.6% at 72 months. The UPDRS-IV decreased by 30.8% at 12 months, 22.1% at 24 months, 25% at 60 months, and 36.5% at 72 months. Dopaminergic therapy showed a progressive reduction, significant at 60 months (11.8%). Quality of life improved by 18.0% at 12 months, and 22.4% at 60 months. No surgical complication, cognitive or behavioral change occurred. The only adverse event reported was an infection of the implantable pulse generator pocket. Even in the long-term follow-up, EMCS was shown to be a safe and effective treatment option in PD patients, resulting in improvements in motor symptoms and quality of life, and reductions in motor complications and dopaminergic therapy. |
| first_indexed | 2024-03-10T12:53:47Z |
| format | Article |
| id | doaj.art-fef12a89290a41ababdecadf511fb6b4 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T12:53:47Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-fef12a89290a41ababdecadf511fb6b42023-11-21T12:07:02ZengMDPI AGBrain Sciences2076-34252021-03-0111441610.3390/brainsci11040416Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical OutcomeCarla Piano0Francesco Bove1Delia Mulas2Enrico Di Stasio3Alfonso Fasano4Anna Rita Bentivoglio5Antonio Daniele6Beatrice Cioni7Paolo Calabresi8Tommaso Tufo9Neurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyInstitute of Neurology, Mater Olbia Hospital, 07026 Olbia, ItalyInstitute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyEdmond J. Safra Program in Parkinson’s Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital and Division of Neurology, University of Toronto, Toronto, ON M5T 2S8, CanadaNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyNeurosurgery Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyNeurosurgery Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyPrevious investigations have reported on the motor benefits and safety of chronic extradural motor cortex stimulation (EMCS) for patients with Parkinson’s disease (PD), but studies addressing the long-term clinical outcome are still lacking. In this study, nine consecutive PD patients who underwent EMCS were prospectively recruited, with a mean follow-up time of 5.1 ± 2.5 years. As compared to the preoperatory baseline, the Unified Parkinson’s Disease Rating Scale (UPDRS)-III in the off-medication condition significantly decreased by 13.8% at 12 months, 16.1% at 18 months, 18.4% at 24 months, 21% at 36 months, 15.6% at 60 months, and 8.6% at 72 months. The UPDRS-IV decreased by 30.8% at 12 months, 22.1% at 24 months, 25% at 60 months, and 36.5% at 72 months. Dopaminergic therapy showed a progressive reduction, significant at 60 months (11.8%). Quality of life improved by 18.0% at 12 months, and 22.4% at 60 months. No surgical complication, cognitive or behavioral change occurred. The only adverse event reported was an infection of the implantable pulse generator pocket. Even in the long-term follow-up, EMCS was shown to be a safe and effective treatment option in PD patients, resulting in improvements in motor symptoms and quality of life, and reductions in motor complications and dopaminergic therapy.https://www.mdpi.com/2076-3425/11/4/416motor cortex stimulationParkinson’s diseasemovement disordersneuromodulation |
| spellingShingle | Carla Piano Francesco Bove Delia Mulas Enrico Di Stasio Alfonso Fasano Anna Rita Bentivoglio Antonio Daniele Beatrice Cioni Paolo Calabresi Tommaso Tufo Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical Outcome Brain Sciences motor cortex stimulation Parkinson’s disease movement disorders neuromodulation |
| title | Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical Outcome |
| title_full | Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical Outcome |
| title_fullStr | Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical Outcome |
| title_full_unstemmed | Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical Outcome |
| title_short | Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical Outcome |
| title_sort | extradural motor cortex stimulation in parkinson s disease long term clinical outcome |
| topic | motor cortex stimulation Parkinson’s disease movement disorders neuromodulation |
| url | https://www.mdpi.com/2076-3425/11/4/416 |
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