A physical perspective to understand myelin. I. A physical answer to Peter’s quadrant mystery
In the development of oligodendrocytes in the central nervous systems, the inner and outer tongue of the myelin sheath tend to be located within the same quadrant, which was named as Peters quadrant mystery. In this study, we conduct in silico investigations to explore the possible mechanisms underl...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.951942/full |
| _version_ | 1818017582032093184 |
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| author | Yonghong Liu Wenji Yue Shoujun Yu Tian Zhou Yapeng Zhang Ran Zhu Bing Song Tianruo Guo Fenglin Liu Yubin Huang Tianzhun Wu Tianzhun Wu Hao Wang Hao Wang |
| author_facet | Yonghong Liu Wenji Yue Shoujun Yu Tian Zhou Yapeng Zhang Ran Zhu Bing Song Tianruo Guo Fenglin Liu Yubin Huang Tianzhun Wu Tianzhun Wu Hao Wang Hao Wang |
| author_sort | Yonghong Liu |
| collection | DOAJ |
| description | In the development of oligodendrocytes in the central nervous systems, the inner and outer tongue of the myelin sheath tend to be located within the same quadrant, which was named as Peters quadrant mystery. In this study, we conduct in silico investigations to explore the possible mechanisms underlying the Peters quadrant mystery. A biophysically detailed model of oligodendrocytes was used to simulate the effect of the actional potential-induced electric field across the myelin sheath. Our simulation suggests that the paranodal channel connecting the inner and outer tongue forms a low impedance route, inducing two high-current zones at the area around the inner and outer tongue. When the inner tongue and outer tongue are located within the same quadrant, the interaction of these two high-current-zones will induce a maximum amplitude and a polarity reverse of the voltage upon the inner tongue, resulting in the same quadrant phenomenon. This model indicates that the growth of myelin follows a simple principle: an external negative or positive E-field can promote or inhibit the growth of the inner tongue, respectively. |
| first_indexed | 2024-04-14T07:28:50Z |
| format | Article |
| id | doaj.art-fef3452c13464d4c8d6f54997871c3f7 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-14T07:28:50Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-fef3452c13464d4c8d6f54997871c3f72022-12-22T02:05:56ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-09-011610.3389/fnins.2022.951942951942A physical perspective to understand myelin. I. A physical answer to Peter’s quadrant mysteryYonghong Liu0Wenji Yue1Shoujun Yu2Tian Zhou3Yapeng Zhang4Ran Zhu5Bing Song6Tianruo Guo7Fenglin Liu8Yubin Huang9Tianzhun Wu10Tianzhun Wu11Hao Wang12Hao Wang13Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, ChinaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, ChinaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, ChinaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, ChinaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, ChinaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, ChinaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, ChinaGraduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW, AustraliaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, ChinaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, ChinaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, ChinaKey Laboratory of Health Bioinformatics, Chinese Academy of Sciences (CAS), Shenzhen, ChinaInstitute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, ChinaKey Laboratory of Health Bioinformatics, Chinese Academy of Sciences (CAS), Shenzhen, ChinaIn the development of oligodendrocytes in the central nervous systems, the inner and outer tongue of the myelin sheath tend to be located within the same quadrant, which was named as Peters quadrant mystery. In this study, we conduct in silico investigations to explore the possible mechanisms underlying the Peters quadrant mystery. A biophysically detailed model of oligodendrocytes was used to simulate the effect of the actional potential-induced electric field across the myelin sheath. Our simulation suggests that the paranodal channel connecting the inner and outer tongue forms a low impedance route, inducing two high-current zones at the area around the inner and outer tongue. When the inner tongue and outer tongue are located within the same quadrant, the interaction of these two high-current-zones will induce a maximum amplitude and a polarity reverse of the voltage upon the inner tongue, resulting in the same quadrant phenomenon. This model indicates that the growth of myelin follows a simple principle: an external negative or positive E-field can promote or inhibit the growth of the inner tongue, respectively.https://www.frontiersin.org/articles/10.3389/fnins.2022.951942/fullPeter’s quadrant mysteryoligodendrocyteE-fieldmodelingelectrical stimulation |
| spellingShingle | Yonghong Liu Wenji Yue Shoujun Yu Tian Zhou Yapeng Zhang Ran Zhu Bing Song Tianruo Guo Fenglin Liu Yubin Huang Tianzhun Wu Tianzhun Wu Hao Wang Hao Wang A physical perspective to understand myelin. I. A physical answer to Peter’s quadrant mystery Frontiers in Neuroscience Peter’s quadrant mystery oligodendrocyte E-field modeling electrical stimulation |
| title | A physical perspective to understand myelin. I. A physical answer to Peter’s quadrant mystery |
| title_full | A physical perspective to understand myelin. I. A physical answer to Peter’s quadrant mystery |
| title_fullStr | A physical perspective to understand myelin. I. A physical answer to Peter’s quadrant mystery |
| title_full_unstemmed | A physical perspective to understand myelin. I. A physical answer to Peter’s quadrant mystery |
| title_short | A physical perspective to understand myelin. I. A physical answer to Peter’s quadrant mystery |
| title_sort | physical perspective to understand myelin i a physical answer to peter s quadrant mystery |
| topic | Peter’s quadrant mystery oligodendrocyte E-field modeling electrical stimulation |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.951942/full |
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