Autophagy—A Story of Bacteria Interfering with the Host Cell Degradation Machinery
Autophagy is a highly conserved and fundamental cellular process to maintain cellular homeostasis through recycling of defective organelles or proteins. In a response to intracellular pathogens, autophagy further acts as an innate immune response mechanism to eliminate pathogens. This review will di...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/2/110 |
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| author | Anna K. Riebisch Sabrina Mühlen Yan Yan Beer Ingo Schmitz |
| author_facet | Anna K. Riebisch Sabrina Mühlen Yan Yan Beer Ingo Schmitz |
| author_sort | Anna K. Riebisch |
| collection | DOAJ |
| description | Autophagy is a highly conserved and fundamental cellular process to maintain cellular homeostasis through recycling of defective organelles or proteins. In a response to intracellular pathogens, autophagy further acts as an innate immune response mechanism to eliminate pathogens. This review will discuss recent findings on autophagy as a reaction to intracellular pathogens, such as <i>Salmonella typhimurium</i>, <i>Listeria monocytogenes</i>, <i>Mycobacterium tuberculosis</i>, <i>Staphylococcus aureus</i>, and pathogenic <i>Escherichia coli</i>. Interestingly, while some of these bacteria have developed methods to use autophagy for their own benefit within the cell, others have developed fascinating mechanisms to evade recognition, to subvert the autophagic pathway, or to escape from autophagy. |
| first_indexed | 2024-03-09T03:59:04Z |
| format | Article |
| id | doaj.art-fef3702fe5594a40ae2ccd243eec9429 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T03:59:04Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-fef3702fe5594a40ae2ccd243eec94292023-12-03T14:16:41ZengMDPI AGPathogens2076-08172021-01-0110211010.3390/pathogens10020110Autophagy—A Story of Bacteria Interfering with the Host Cell Degradation MachineryAnna K. Riebisch0Sabrina Mühlen1Yan Yan Beer2Ingo Schmitz3Department of Molecular Immunology, Ruhr-University Bochum, 44801 Bochum, GermanyDepartment of Molecular Immunology, Ruhr-University Bochum, 44801 Bochum, GermanySystems-Oriented Immunology & Inflammation Research, Helmholtz Centre for Infection Research, 38124 Braunschweig, GermanyDepartment of Molecular Immunology, Ruhr-University Bochum, 44801 Bochum, GermanyAutophagy is a highly conserved and fundamental cellular process to maintain cellular homeostasis through recycling of defective organelles or proteins. In a response to intracellular pathogens, autophagy further acts as an innate immune response mechanism to eliminate pathogens. This review will discuss recent findings on autophagy as a reaction to intracellular pathogens, such as <i>Salmonella typhimurium</i>, <i>Listeria monocytogenes</i>, <i>Mycobacterium tuberculosis</i>, <i>Staphylococcus aureus</i>, and pathogenic <i>Escherichia coli</i>. Interestingly, while some of these bacteria have developed methods to use autophagy for their own benefit within the cell, others have developed fascinating mechanisms to evade recognition, to subvert the autophagic pathway, or to escape from autophagy.https://www.mdpi.com/2076-0817/10/2/110autophagyxenophagypathogenspattern recognition receptorsinnate immune response |
| spellingShingle | Anna K. Riebisch Sabrina Mühlen Yan Yan Beer Ingo Schmitz Autophagy—A Story of Bacteria Interfering with the Host Cell Degradation Machinery Pathogens autophagy xenophagy pathogens pattern recognition receptors innate immune response |
| title | Autophagy—A Story of Bacteria Interfering with the Host Cell Degradation Machinery |
| title_full | Autophagy—A Story of Bacteria Interfering with the Host Cell Degradation Machinery |
| title_fullStr | Autophagy—A Story of Bacteria Interfering with the Host Cell Degradation Machinery |
| title_full_unstemmed | Autophagy—A Story of Bacteria Interfering with the Host Cell Degradation Machinery |
| title_short | Autophagy—A Story of Bacteria Interfering with the Host Cell Degradation Machinery |
| title_sort | autophagy a story of bacteria interfering with the host cell degradation machinery |
| topic | autophagy xenophagy pathogens pattern recognition receptors innate immune response |
| url | https://www.mdpi.com/2076-0817/10/2/110 |
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