Inflammatory bowel diseases: Transformation of representations. A review
The global burden of inflammatory bowel disease (IBD) is currently significant and continues to grow due to the increasing prevalence of ulcerative colitis (UC) and Crohn's disease (CD), the increasing costs of diagnosis and treatment, and the high level of disability in patients with this dise...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2023-12-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/625326/pdf |
| _version_ | 1797261544024702976 |
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| author | Igor V. Maev Igor G. Bakulin Maria I. Skalinskaya Ekaterina V. Skazyvaeva |
| author_facet | Igor V. Maev Igor G. Bakulin Maria I. Skalinskaya Ekaterina V. Skazyvaeva |
| author_sort | Igor V. Maev |
| collection | DOAJ |
| description | The global burden of inflammatory bowel disease (IBD) is currently significant and continues to grow due to the increasing prevalence of ulcerative colitis (UC) and Crohn's disease (CD), the increasing costs of diagnosis and treatment, and the high level of disability in patients with this disease. Categories, which leads to the search for risk factors and predictors of aggressive course and extraintestinal manifestations. According to the latest data, the prevalence of UC in Russia is 16.6 per 100 000 population, the annual registered increase is 11.3%; the prevalence of CD is 5.6 per 100 000 population, and the increase is 13.7%. In the Russian population of patients with IBD, the average age of disease onset is 35.3 years for UC and 31.2 years for CD. Moreover, in 89.3% of patients with UC, it took at least 2 years to verify the diagnosis, and in CD, within 2 years from the onset of clinical symptoms, the diagnosis was established in only 72.6% of patients. One of the dominant characteristics of IBD is its multisystem nature, which leads to the development of extraintestinal manifestations (ECM), which can be observed in 50–60% of patients, while up to 25% of patients with IBD have several EMC and the most common variants are joint lesions. A higher frequency of extraintestinal manifestations is observed in CD (up to 45% of patients), in female patients, in smokers and with a longer duration of the disease. To predict clinical remission, the level of fecal calprotectin and CRP, the need for glucocorticosteroids are important, to predict endoscopic remission – the level of fecal calprotectin, and to predict histological remission, an endoscopic Schroeder index value of ≤1 is important. The absolute risk of developing colorectal cancer in IBD remains relatively low, ranging from 1.1 to 5.4% after 20 years of disease. The main risk factors for IBD are total intestinal damage, high inflammatory activity, the stricturing phenotype of CD and the presence of primary sclerosing cholangitis. |
| first_indexed | 2024-03-08T18:26:19Z |
| format | Article |
| id | doaj.art-fef5ef4d94874114b9d64c73ac23c9cc |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-04-24T23:42:54Z |
| publishDate | 2023-12-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-fef5ef4d94874114b9d64c73ac23c9cc2024-03-15T10:06:08Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422023-12-0195121064107410.26442/00403660.2023.12.20250778408Inflammatory bowel diseases: Transformation of representations. A reviewIgor V. Maev0https://orcid.org/0000-0001-6114-564XIgor G. Bakulin1https://orcid.org/0000-0002-6151-2021Maria I. Skalinskaya2https://orcid.org/0000-0003-0769-8176Ekaterina V. Skazyvaeva3https://orcid.org/0000-0002-8563-6870Yevdokimov Moscow State University of Medicine and DentistryMechnikov North-Western State Medical UniversityMechnikov North-Western State Medical UniversityMechnikov North-Western State Medical UniversityThe global burden of inflammatory bowel disease (IBD) is currently significant and continues to grow due to the increasing prevalence of ulcerative colitis (UC) and Crohn's disease (CD), the increasing costs of diagnosis and treatment, and the high level of disability in patients with this disease. Categories, which leads to the search for risk factors and predictors of aggressive course and extraintestinal manifestations. According to the latest data, the prevalence of UC in Russia is 16.6 per 100 000 population, the annual registered increase is 11.3%; the prevalence of CD is 5.6 per 100 000 population, and the increase is 13.7%. In the Russian population of patients with IBD, the average age of disease onset is 35.3 years for UC and 31.2 years for CD. Moreover, in 89.3% of patients with UC, it took at least 2 years to verify the diagnosis, and in CD, within 2 years from the onset of clinical symptoms, the diagnosis was established in only 72.6% of patients. One of the dominant characteristics of IBD is its multisystem nature, which leads to the development of extraintestinal manifestations (ECM), which can be observed in 50–60% of patients, while up to 25% of patients with IBD have several EMC and the most common variants are joint lesions. A higher frequency of extraintestinal manifestations is observed in CD (up to 45% of patients), in female patients, in smokers and with a longer duration of the disease. To predict clinical remission, the level of fecal calprotectin and CRP, the need for glucocorticosteroids are important, to predict endoscopic remission – the level of fecal calprotectin, and to predict histological remission, an endoscopic Schroeder index value of ≤1 is important. The absolute risk of developing colorectal cancer in IBD remains relatively low, ranging from 1.1 to 5.4% after 20 years of disease. The main risk factors for IBD are total intestinal damage, high inflammatory activity, the stricturing phenotype of CD and the presence of primary sclerosing cholangitis.https://ter-arkhiv.ru/0040-3660/article/viewFile/625326/pdfinflammatory bowel diseasescrohn's diseaseulcerative colitisepidemiologycomplicationsrisk factorsextraintestinal manifestationsprognosis |
| spellingShingle | Igor V. Maev Igor G. Bakulin Maria I. Skalinskaya Ekaterina V. Skazyvaeva Inflammatory bowel diseases: Transformation of representations. A review Терапевтический архив inflammatory bowel diseases crohn's disease ulcerative colitis epidemiology complications risk factors extraintestinal manifestations prognosis |
| title | Inflammatory bowel diseases: Transformation of representations. A review |
| title_full | Inflammatory bowel diseases: Transformation of representations. A review |
| title_fullStr | Inflammatory bowel diseases: Transformation of representations. A review |
| title_full_unstemmed | Inflammatory bowel diseases: Transformation of representations. A review |
| title_short | Inflammatory bowel diseases: Transformation of representations. A review |
| title_sort | inflammatory bowel diseases transformation of representations a review |
| topic | inflammatory bowel diseases crohn's disease ulcerative colitis epidemiology complications risk factors extraintestinal manifestations prognosis |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/625326/pdf |
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