The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications
Prostate cancer is a global public health problem, and it is the most common cancer in American men and the second cause for cancer-related death. Experimental evidence shows that prostate tissue possesses cannabinoid receptors and their stimulation results in anti-androgenic effects. To review curr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Indian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.indianjurol.com/article.asp?issn=0970-1591;year=2012;volume=28;issue=1;spage=9;epage=14;aulast=Ramos |
| _version_ | 1811230796571213824 |
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| author | Juan A Ramos Fernando J Bianco |
| author_facet | Juan A Ramos Fernando J Bianco |
| author_sort | Juan A Ramos |
| collection | DOAJ |
| description | Prostate cancer is a global public health problem, and it is the most common cancer in American men and the second cause for cancer-related death. Experimental evidence shows that prostate tissue possesses cannabinoid receptors and their stimulation results in anti-androgenic effects. To review currently relevant findings related to effects of cannabinoid receptors in prostate cancer. PubMed search utilizing the terms "cannabis," "cannabinoids," "prostate cancer," and "cancer pain management," giving preference to most recent publications was done. Articles identified were screened for their relevance to the field of prostate cancer and interest to both urologist and pain specialists. Prostate cancer cells possess increased expression of both cannabinoid 1 and 2 receptors, and stimulation of these results in decrease in cell viability, increased apoptosis, and decreased androgen receptor expression and prostate-specific antigen excretion. It would be of interest to conduct clinical studies utilizing cannabinoids for patients with metastatic prostate cancer, taking advantage not only of its beneficial effects on prostate cancer but also of their analgesic properties for bone metastatic cancer pain. |
| first_indexed | 2024-04-12T10:34:19Z |
| format | Article |
| id | doaj.art-fef5f1086e41464aa41a4a3dbfd386fb |
| institution | Directory Open Access Journal |
| issn | 0970-1591 1998-3824 |
| language | English |
| last_indexed | 2024-04-12T10:34:19Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Urology |
| spelling | doaj.art-fef5f1086e41464aa41a4a3dbfd386fb2022-12-22T03:36:46ZengWolters Kluwer Medknow PublicationsIndian Journal of Urology0970-15911998-38242012-01-0128191410.4103/0970-1591.94942The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applicationsJuan A RamosFernando J BiancoProstate cancer is a global public health problem, and it is the most common cancer in American men and the second cause for cancer-related death. Experimental evidence shows that prostate tissue possesses cannabinoid receptors and their stimulation results in anti-androgenic effects. To review currently relevant findings related to effects of cannabinoid receptors in prostate cancer. PubMed search utilizing the terms "cannabis," "cannabinoids," "prostate cancer," and "cancer pain management," giving preference to most recent publications was done. Articles identified were screened for their relevance to the field of prostate cancer and interest to both urologist and pain specialists. Prostate cancer cells possess increased expression of both cannabinoid 1 and 2 receptors, and stimulation of these results in decrease in cell viability, increased apoptosis, and decreased androgen receptor expression and prostate-specific antigen excretion. It would be of interest to conduct clinical studies utilizing cannabinoids for patients with metastatic prostate cancer, taking advantage not only of its beneficial effects on prostate cancer but also of their analgesic properties for bone metastatic cancer pain.http://www.indianjurol.com/article.asp?issn=0970-1591;year=2012;volume=28;issue=1;spage=9;epage=14;aulast=RamosAndrogen antagonistscannabiscannabinoidsinvestigational therapiesprostatic neoplasms |
| spellingShingle | Juan A Ramos Fernando J Bianco The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications Indian Journal of Urology Androgen antagonists cannabis cannabinoids investigational therapies prostatic neoplasms |
| title | The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications |
| title_full | The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications |
| title_fullStr | The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications |
| title_full_unstemmed | The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications |
| title_short | The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications |
| title_sort | role of cannabinoids in prostate cancer basic science perspective and potential clinical applications |
| topic | Androgen antagonists cannabis cannabinoids investigational therapies prostatic neoplasms |
| url | http://www.indianjurol.com/article.asp?issn=0970-1591;year=2012;volume=28;issue=1;spage=9;epage=14;aulast=Ramos |
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