Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst
This article deal with the parallel synthesis of a 96 product-sized library using a polymer-based copper catalyst that we developed which can be easily separated from the products by simple filtration. This gave us the opportunity to use this catalyst in an automated chemical synthesis station (Chem...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2010-04-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/15/5/3087/ |
| _version_ | 1819029172615380992 |
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| author | Faouzi Meganem Christian Girard Jean Herscovici Eihab Khaba Aymeric Beauvineau Marie Aufort Esra Önen Sophie Beauvière Claire Beauvineau Ibtissem Jlalia |
| author_facet | Faouzi Meganem Christian Girard Jean Herscovici Eihab Khaba Aymeric Beauvineau Marie Aufort Esra Önen Sophie Beauvière Claire Beauvineau Ibtissem Jlalia |
| author_sort | Faouzi Meganem |
| collection | DOAJ |
| description | This article deal with the parallel synthesis of a 96 product-sized library using a polymer-based copper catalyst that we developed which can be easily separated from the products by simple filtration. This gave us the opportunity to use this catalyst in an automated chemical synthesis station (Chemspeed ASW-2000). Studies and results about the preparation of the catalyst, its use in different solvent systems, its recycling capabilities and its scope and limitations in the synthesis of this library will be addressed. The synthesis of the triazole library and the very good results obtained will finally be discussed. |
| first_indexed | 2024-12-21T06:10:02Z |
| format | Article |
| id | doaj.art-fef7602291194b3999586bbdafb13919 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-21T06:10:02Z |
| publishDate | 2010-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-fef7602291194b3999586bbdafb139192022-12-21T19:13:34ZengMDPI AGMolecules1420-30492010-04-011553087312010.3390/molecules15053087Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper CatalystFaouzi MeganemChristian GirardJean HerscoviciEihab KhabaAymeric BeauvineauMarie AufortEsra ÖnenSophie BeauvièreClaire BeauvineauIbtissem JlaliaThis article deal with the parallel synthesis of a 96 product-sized library using a polymer-based copper catalyst that we developed which can be easily separated from the products by simple filtration. This gave us the opportunity to use this catalyst in an automated chemical synthesis station (Chemspeed ASW-2000). Studies and results about the preparation of the catalyst, its use in different solvent systems, its recycling capabilities and its scope and limitations in the synthesis of this library will be addressed. The synthesis of the triazole library and the very good results obtained will finally be discussed.http://www.mdpi.com/1420-3049/15/5/3087/click chemistryHuisgen cycloadditioncopper (I) catalysistriazolessupported catalystparallel synthesis |
| spellingShingle | Faouzi Meganem Christian Girard Jean Herscovici Eihab Khaba Aymeric Beauvineau Marie Aufort Esra Önen Sophie Beauvière Claire Beauvineau Ibtissem Jlalia Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst Molecules click chemistry Huisgen cycloaddition copper (I) catalysis triazoles supported catalyst parallel synthesis |
| title | Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst |
| title_full | Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst |
| title_fullStr | Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst |
| title_full_unstemmed | Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst |
| title_short | Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst |
| title_sort | automated synthesis of a 96 product sized library of triazole derivatives using a solid phase supported copper catalyst |
| topic | click chemistry Huisgen cycloaddition copper (I) catalysis triazoles supported catalyst parallel synthesis |
| url | http://www.mdpi.com/1420-3049/15/5/3087/ |
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