Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on <i>S. epidermidis</i>
Medical devices with an effective anti-colonization surface are important tools for combatting healthcare-associated infections. Here, we investigated the anti-colonization efficacy of antimicrobial peptides covalently attached to a gold model surface. The gold surface was modified by a self-assembl...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/12/1516 |
| _version_ | 1827674417088430080 |
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| author | Eskil André Karlsen Wenche Stensen Eric Juskewitz Johan Svenson Mattias Berglin John Sigurd Mjøen Svendsen |
| author_facet | Eskil André Karlsen Wenche Stensen Eric Juskewitz Johan Svenson Mattias Berglin John Sigurd Mjøen Svendsen |
| author_sort | Eskil André Karlsen |
| collection | DOAJ |
| description | Medical devices with an effective anti-colonization surface are important tools for combatting healthcare-associated infections. Here, we investigated the anti-colonization efficacy of antimicrobial peptides covalently attached to a gold model surface. The gold surface was modified by a self-assembled polyethylene glycol monolayer with an acetylene terminus. The peptides were covalently connected to the surface through a copper-catalyzed [3 + 2] azide-acetylene coupling (CuAAC). The anti-colonization efficacy of the surfaces varied as a function of the antimicrobial activity of the peptides, and very effective surfaces could be prepared with a 6 log unit reduction in bacterial colonization. |
| first_indexed | 2024-03-10T04:39:10Z |
| format | Article |
| id | doaj.art-fef7aea895c54d249e5aa4cf20e0511d |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T04:39:10Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-fef7aea895c54d249e5aa4cf20e0511d2023-11-23T03:31:05ZengMDPI AGAntibiotics2079-63822021-12-011012151610.3390/antibiotics10121516Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on <i>S. epidermidis</i>Eskil André Karlsen0Wenche Stensen1Eric Juskewitz2Johan Svenson3Mattias Berglin4John Sigurd Mjøen Svendsen5Amicoat AS, Sykehusvegen 23, 9019 Tromsø, NorwayAmicoat AS, Sykehusvegen 23, 9019 Tromsø, NorwayDepartment of Medical Biology, Faculty of Health Sciences, UiT—The Arctic University of Norway, 9037 Tromsø, NorwayRISE Research Institutes of Sweden, Brinellgatan 4, 504 62 Borås, SwedenRISE Research Institutes of Sweden, Brinellgatan 4, 504 62 Borås, SwedenAmicoat AS, Sykehusvegen 23, 9019 Tromsø, NorwayMedical devices with an effective anti-colonization surface are important tools for combatting healthcare-associated infections. Here, we investigated the anti-colonization efficacy of antimicrobial peptides covalently attached to a gold model surface. The gold surface was modified by a self-assembled polyethylene glycol monolayer with an acetylene terminus. The peptides were covalently connected to the surface through a copper-catalyzed [3 + 2] azide-acetylene coupling (CuAAC). The anti-colonization efficacy of the surfaces varied as a function of the antimicrobial activity of the peptides, and very effective surfaces could be prepared with a 6 log unit reduction in bacterial colonization.https://www.mdpi.com/2079-6382/10/12/1516antimicrobial surfaceantimicrobial peptideself-assembled monolayerantifoulinganti-colonizationToF-SIMS imaging |
| spellingShingle | Eskil André Karlsen Wenche Stensen Eric Juskewitz Johan Svenson Mattias Berglin John Sigurd Mjøen Svendsen Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on <i>S. epidermidis</i> Antibiotics antimicrobial surface antimicrobial peptide self-assembled monolayer antifouling anti-colonization ToF-SIMS imaging |
| title | Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on <i>S. epidermidis</i> |
| title_full | Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on <i>S. epidermidis</i> |
| title_fullStr | Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on <i>S. epidermidis</i> |
| title_full_unstemmed | Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on <i>S. epidermidis</i> |
| title_short | Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on <i>S. epidermidis</i> |
| title_sort | anti colonization effect of au surfaces with self assembled molecular monolayers functionalized with antimicrobial peptides on i s epidermidis i |
| topic | antimicrobial surface antimicrobial peptide self-assembled monolayer antifouling anti-colonization ToF-SIMS imaging |
| url | https://www.mdpi.com/2079-6382/10/12/1516 |
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