Research Progress of Acquired Resistance Mediated by MET Amplification in Advanced Non-small Cell Lung Cancer
Mesenchymal-epithelial transition factor (MET) amplification is an important driver of resistance in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC), and the combination of MET proto-oncogene (MET) and EGFR-tyrosine kinase inhibitors (TKIs) has shown promise in over...
| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2022-08-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2022.102.23 |
| _version_ | 1798037014829858816 |
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| author | Sisi PAN Na WANG Xia SONG |
| author_facet | Sisi PAN Na WANG Xia SONG |
| author_sort | Sisi PAN |
| collection | DOAJ |
| description | Mesenchymal-epithelial transition factor (MET) amplification is an important driver of resistance in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC), and the combination of MET proto-oncogene (MET) and EGFR-tyrosine kinase inhibitors (TKIs) has shown promise in overcoming this molecularly defined acquired resistance. Emerging data also demonstrate MET amplification as a resistance driver to TKIs-treated anaplastic lymphoma kinase (ALK)-, RET-, and ROS1-fusion NSCLC. Here, we review the literature on recent research progress of MET amplification as a resistance driver to targeted therapy in oncogene-driven NSCLC and summarize the progress of clinical strategies to overcome the resistance mechanism. |
| first_indexed | 2024-04-11T21:20:53Z |
| format | Article |
| id | doaj.art-fef825899f304a7ab658c7db0724bbe9 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-04-11T21:20:53Z |
| publishDate | 2022-08-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-fef825899f304a7ab658c7db0724bbe92022-12-22T04:02:38ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872022-08-0125861562110.3779/j.issn.1009-3419.2022.102.23Research Progress of Acquired Resistance Mediated by MET Amplification
in Advanced Non-small Cell Lung CancerSisi PAN0Na WANG1Xia SONG2The Second Clinical Medical College of Shanxi Medical University, Taiyuan 030001, ChinaThe Second Clinical Medical College of Shanxi Medical University, Taiyuan 030001, ChinaThe Second Department of Respiratory, Shanxi Provincial Cancer Hospital, Taiyuan 030013, ChinaMesenchymal-epithelial transition factor (MET) amplification is an important driver of resistance in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC), and the combination of MET proto-oncogene (MET) and EGFR-tyrosine kinase inhibitors (TKIs) has shown promise in overcoming this molecularly defined acquired resistance. Emerging data also demonstrate MET amplification as a resistance driver to TKIs-treated anaplastic lymphoma kinase (ALK)-, RET-, and ROS1-fusion NSCLC. Here, we review the literature on recent research progress of MET amplification as a resistance driver to targeted therapy in oncogene-driven NSCLC and summarize the progress of clinical strategies to overcome the resistance mechanism.http://dx.doi.org/10.3779/j.issn.1009-3419.2022.102.23lung neoplasmstargeted therapymet amplificationacquired resistance |
| spellingShingle | Sisi PAN Na WANG Xia SONG Research Progress of Acquired Resistance Mediated by MET Amplification in Advanced Non-small Cell Lung Cancer Chinese Journal of Lung Cancer lung neoplasms targeted therapy met amplification acquired resistance |
| title | Research Progress of Acquired Resistance Mediated by MET Amplification
in Advanced Non-small Cell Lung Cancer |
| title_full | Research Progress of Acquired Resistance Mediated by MET Amplification
in Advanced Non-small Cell Lung Cancer |
| title_fullStr | Research Progress of Acquired Resistance Mediated by MET Amplification
in Advanced Non-small Cell Lung Cancer |
| title_full_unstemmed | Research Progress of Acquired Resistance Mediated by MET Amplification
in Advanced Non-small Cell Lung Cancer |
| title_short | Research Progress of Acquired Resistance Mediated by MET Amplification
in Advanced Non-small Cell Lung Cancer |
| title_sort | research progress of acquired resistance mediated by met amplification
in advanced non small cell lung cancer |
| topic | lung neoplasms targeted therapy met amplification acquired resistance |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2022.102.23 |
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