Application of an excipient made from chitosan and xanthan gum as a single component for the controlled release of Ambroxol
An oral controlled release (CR) matrix system of Ambroxol hydrochloride was developed using a binary hydrophilic polymer mixture of chitosan (CH) and xanthan gum (XG) (1:1 w/w ratio). Two test tablet formulations were prepared using drug to polymer mixture ratios (D:P) of 1:1 and 1:3 (w/w), designat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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International Pharmaceutical Excipients Council
2016-11-01
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| Series: | Journal of Excipients and Food Chemicals |
| Online Access: | https://jefc.scholasticahq.com/article/1087-application-of-an-excipient-made-from-chitosan-and-xanthan-gum-as-a-single-component-for-the-controlled-release-of-ambroxol |
| _version_ | 1797254415375138816 |
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| author | Mayyas Al Remawi Faisal Al-Akayleh Mutaz S. Salem Munther Al Shami Adnan Badwan |
| author_facet | Mayyas Al Remawi Faisal Al-Akayleh Mutaz S. Salem Munther Al Shami Adnan Badwan |
| author_sort | Mayyas Al Remawi |
| collection | DOAJ |
| description | An oral controlled release (CR) matrix system of Ambroxol hydrochloride was developed using a binary hydrophilic polymer mixture of chitosan (CH) and xanthan gum (XG) (1:1 w/w ratio). Two test tablet formulations were prepared using drug to polymer mixture ratios (D:P) of 1:1 and 1:3 (w/w), designated as
T1 and T2, respectively. The in vitro drug release data was best fitted to the Higuchi equation. The 1:1 ratio (T1) demonstrated in vitro dissolution similarity with the commercial product, Mucosolvan LA. A preliminary
in vivo study was performed using six volunteers. The study was designed to include open, randomized, singledose, three-treatment, six-sequence, crossover (Williams design) under fasting conditions. The data showed
that T1 was bioequivalent to Mucosolvan LA ® after the administration of a single 75mg oral dose. Two in vivo, in vitro correlations (IVIVC) were established between Cmax versus the fraction of drug dissolved (FRD)
after 4 hours, and AUC versus the ratio of fraction of drug dissolved (FRD) after 10 hours where a multiple point level C correlation of IVIVC was obtained. |
| first_indexed | 2024-04-24T21:49:35Z |
| format | Article |
| id | doaj.art-fef85a9611734793b527835f7e512887 |
| institution | Directory Open Access Journal |
| issn | 2150-2668 |
| language | English |
| last_indexed | 2024-04-24T21:49:35Z |
| publishDate | 2016-11-01 |
| publisher | International Pharmaceutical Excipients Council |
| record_format | Article |
| series | Journal of Excipients and Food Chemicals |
| spelling | doaj.art-fef85a9611734793b527835f7e5128872024-03-20T18:01:25ZengInternational Pharmaceutical Excipients CouncilJournal of Excipients and Food Chemicals2150-26682016-11-0142Application of an excipient made from chitosan and xanthan gum as a single component for the controlled release of AmbroxolMayyas Al RemawiFaisal Al-AkaylehMutaz S. SalemMunther Al ShamiAdnan BadwanAn oral controlled release (CR) matrix system of Ambroxol hydrochloride was developed using a binary hydrophilic polymer mixture of chitosan (CH) and xanthan gum (XG) (1:1 w/w ratio). Two test tablet formulations were prepared using drug to polymer mixture ratios (D:P) of 1:1 and 1:3 (w/w), designated as T1 and T2, respectively. The in vitro drug release data was best fitted to the Higuchi equation. The 1:1 ratio (T1) demonstrated in vitro dissolution similarity with the commercial product, Mucosolvan LA. A preliminary in vivo study was performed using six volunteers. The study was designed to include open, randomized, singledose, three-treatment, six-sequence, crossover (Williams design) under fasting conditions. The data showed that T1 was bioequivalent to Mucosolvan LA ® after the administration of a single 75mg oral dose. Two in vivo, in vitro correlations (IVIVC) were established between Cmax versus the fraction of drug dissolved (FRD) after 4 hours, and AUC versus the ratio of fraction of drug dissolved (FRD) after 10 hours where a multiple point level C correlation of IVIVC was obtained.https://jefc.scholasticahq.com/article/1087-application-of-an-excipient-made-from-chitosan-and-xanthan-gum-as-a-single-component-for-the-controlled-release-of-ambroxol |
| spellingShingle | Mayyas Al Remawi Faisal Al-Akayleh Mutaz S. Salem Munther Al Shami Adnan Badwan Application of an excipient made from chitosan and xanthan gum as a single component for the controlled release of Ambroxol Journal of Excipients and Food Chemicals |
| title | Application of an excipient made from chitosan and xanthan gum as a single component for the controlled release of Ambroxol |
| title_full | Application of an excipient made from chitosan and xanthan gum as a single component for the controlled release of Ambroxol |
| title_fullStr | Application of an excipient made from chitosan and xanthan gum as a single component for the controlled release of Ambroxol |
| title_full_unstemmed | Application of an excipient made from chitosan and xanthan gum as a single component for the controlled release of Ambroxol |
| title_short | Application of an excipient made from chitosan and xanthan gum as a single component for the controlled release of Ambroxol |
| title_sort | application of an excipient made from chitosan and xanthan gum as a single component for the controlled release of ambroxol |
| url | https://jefc.scholasticahq.com/article/1087-application-of-an-excipient-made-from-chitosan-and-xanthan-gum-as-a-single-component-for-the-controlled-release-of-ambroxol |
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