The Association between Inflammatory and Nutritional Markers and Survival in Elderly Patients Operated for Lung Cancer
Aim: Today, there is an increase in cancer incidence and cancer-related deaths in the elderly population. This study aimed to evaluate the impact of neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) levels on the survival rate in elderly patients diagnosed with non-small ce...
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| Format: | Article |
| Language: | English |
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Duzce University
2023-08-01
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| Series: | Düzce Tıp Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/en/download/article-file/3098572 |
| _version_ | 1797425866903388160 |
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| author | Sinan Issı Dalokay Kılıç Alper Fındıkçıoğlu Oya Yıldız |
| author_facet | Sinan Issı Dalokay Kılıç Alper Fındıkçıoğlu Oya Yıldız |
| author_sort | Sinan Issı |
| collection | DOAJ |
| description | Aim: Today, there is an increase in cancer incidence and cancer-related deaths in the elderly population. This study aimed to evaluate the impact of neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) levels on the survival rate in elderly patients diagnosed with non-small cell lung cancer (NSCLC).
Material and Methods: A total of 73 patients (aged ≥70 years) who operated for NSCLC between 2012 and 2018 were included in this study. Patient records were analyzed retrospectively. The NLR value was calculated with the blood neutrophil count/lymphocyte count formula. The cut-off value for NLR was considered as 2.5. The PNI value was calculated as 10 x serum albumin (g/dL) + 0.005 × total lymphocyte count (per millimeter). PNI values lower than 50 were considered as low.
Results: The mean age of the patients was 74.15±3.23 years, 59 (80.8%) patients were male and 14 (19.2%) were female. No statistically significant relation of postoperative complication was noted with PNI (p=0.354) and NLR (p=0.483). Postoperative mortality was not significantly associated with PNI (p=0.188) and NLR (p=0.465). For patients with NLR <2.5, 1-, 3-, and 5-year survival rates were at 86.0%, 86.1%, and 78.3%, respectively, while these rates were at 76.9%, 65.2%, and 24.8%, respectively, for patients with NLR >2.5 (p=0.028).
Conclusion: Results revealed a significant association of NLR with survival rates in elderly patients with NSCLC. NLR can be considered inexpensive, easily measurable, and reproducible marker that can be incorporated into routine clinical practice for guiding and optimizing treatment decisions in patients with NSCLC. |
| first_indexed | 2024-03-09T08:22:15Z |
| format | Article |
| id | doaj.art-fefb04929d1b4d809206a2c85ec39074 |
| institution | Directory Open Access Journal |
| issn | 1307-671X |
| language | English |
| last_indexed | 2024-03-09T08:22:15Z |
| publishDate | 2023-08-01 |
| publisher | Duzce University |
| record_format | Article |
| series | Düzce Tıp Fakültesi Dergisi |
| spelling | doaj.art-fefb04929d1b4d809206a2c85ec390742023-12-02T21:47:38ZengDuzce UniversityDüzce Tıp Fakültesi Dergisi1307-671X2023-08-0125219519910.18678/dtfd.128663997The Association between Inflammatory and Nutritional Markers and Survival in Elderly Patients Operated for Lung CancerSinan Issı0Dalokay Kılıç1Alper Fındıkçıoğlu2Oya Yıldız3BAŞKENT ÜNİVERSİTESİ, TIP FAKÜLTESİBAŞKENT ÜNİVERSİTESİ, TIP FAKÜLTESİBAŞKENT ÜNİVERSİTESİ, TIP FAKÜLTESİBAŞKENT ÜNİVERSİTESİ, TIP FAKÜLTESİAim: Today, there is an increase in cancer incidence and cancer-related deaths in the elderly population. This study aimed to evaluate the impact of neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) levels on the survival rate in elderly patients diagnosed with non-small cell lung cancer (NSCLC). Material and Methods: A total of 73 patients (aged ≥70 years) who operated for NSCLC between 2012 and 2018 were included in this study. Patient records were analyzed retrospectively. The NLR value was calculated with the blood neutrophil count/lymphocyte count formula. The cut-off value for NLR was considered as 2.5. The PNI value was calculated as 10 x serum albumin (g/dL) + 0.005 × total lymphocyte count (per millimeter). PNI values lower than 50 were considered as low. Results: The mean age of the patients was 74.15±3.23 years, 59 (80.8%) patients were male and 14 (19.2%) were female. No statistically significant relation of postoperative complication was noted with PNI (p=0.354) and NLR (p=0.483). Postoperative mortality was not significantly associated with PNI (p=0.188) and NLR (p=0.465). For patients with NLR <2.5, 1-, 3-, and 5-year survival rates were at 86.0%, 86.1%, and 78.3%, respectively, while these rates were at 76.9%, 65.2%, and 24.8%, respectively, for patients with NLR >2.5 (p=0.028). Conclusion: Results revealed a significant association of NLR with survival rates in elderly patients with NSCLC. NLR can be considered inexpensive, easily measurable, and reproducible marker that can be incorporated into routine clinical practice for guiding and optimizing treatment decisions in patients with NSCLC.https://dergipark.org.tr/en/download/article-file/3098572lung cancerelderly populationnlrpnipostoperative mortalityakciğer kanserinlrpnipostoperatif mortaliteyaşlı nüfus |
| spellingShingle | Sinan Issı Dalokay Kılıç Alper Fındıkçıoğlu Oya Yıldız The Association between Inflammatory and Nutritional Markers and Survival in Elderly Patients Operated for Lung Cancer Düzce Tıp Fakültesi Dergisi lung cancer elderly population nlr pni postoperative mortality akciğer kanseri nlr pni postoperatif mortalite yaşlı nüfus |
| title | The Association between Inflammatory and Nutritional Markers and Survival in Elderly Patients Operated for Lung Cancer |
| title_full | The Association between Inflammatory and Nutritional Markers and Survival in Elderly Patients Operated for Lung Cancer |
| title_fullStr | The Association between Inflammatory and Nutritional Markers and Survival in Elderly Patients Operated for Lung Cancer |
| title_full_unstemmed | The Association between Inflammatory and Nutritional Markers and Survival in Elderly Patients Operated for Lung Cancer |
| title_short | The Association between Inflammatory and Nutritional Markers and Survival in Elderly Patients Operated for Lung Cancer |
| title_sort | association between inflammatory and nutritional markers and survival in elderly patients operated for lung cancer |
| topic | lung cancer elderly population nlr pni postoperative mortality akciğer kanseri nlr pni postoperatif mortalite yaşlı nüfus |
| url | https://dergipark.org.tr/en/download/article-file/3098572 |
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