Mesenchymal stem cell-derived exosomes as a promising cell-free therapy for knee osteoarthritis
Osteoarthritis (OA), as a degenerative disease, leads to high socioeconomic burdens and disability rates. The knee joint is typically the most affected and is characterized by progressive destruction of articular cartilage, subchondral bone remodeling, osteophyte formation and synovial inflammation....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1309946/full |
| _version_ | 1797354468291903488 |
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| author | Danni Luo Hao Zhu Song Li Zhenggang Wang Jun Xiao |
| author_facet | Danni Luo Hao Zhu Song Li Zhenggang Wang Jun Xiao |
| author_sort | Danni Luo |
| collection | DOAJ |
| description | Osteoarthritis (OA), as a degenerative disease, leads to high socioeconomic burdens and disability rates. The knee joint is typically the most affected and is characterized by progressive destruction of articular cartilage, subchondral bone remodeling, osteophyte formation and synovial inflammation. The current management of OA mainly focuses on symptomatic relief and does not help to slow down the advancement of disease. Recently, mesenchymal stem cells (MSCs) and their exosomes have garnered significant attention in regenerative therapy and tissue engineering areas. Preclinical studies have demonstrated that MSC-derived exosomes (MSC-Exos), as bioactive factor carriers, have promising results in cell-free therapy of OA. This study reviewed the application of various MSC-Exos for the OA treatment, along with exploring the potential underlying mechanisms. Moreover, current strategies and future perspectives for the utilization of engineered MSC-Exos, alongside their associated challenges, were also discussed. |
| first_indexed | 2024-03-08T13:50:50Z |
| format | Article |
| id | doaj.art-fefdb52602c348dc8cf265cccb20efa8 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-08T13:50:50Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-fefdb52602c348dc8cf265cccb20efa82024-01-16T04:37:17ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-01-011210.3389/fbioe.2024.13099461309946Mesenchymal stem cell-derived exosomes as a promising cell-free therapy for knee osteoarthritisDanni LuoHao ZhuSong LiZhenggang WangJun XiaoOsteoarthritis (OA), as a degenerative disease, leads to high socioeconomic burdens and disability rates. The knee joint is typically the most affected and is characterized by progressive destruction of articular cartilage, subchondral bone remodeling, osteophyte formation and synovial inflammation. The current management of OA mainly focuses on symptomatic relief and does not help to slow down the advancement of disease. Recently, mesenchymal stem cells (MSCs) and their exosomes have garnered significant attention in regenerative therapy and tissue engineering areas. Preclinical studies have demonstrated that MSC-derived exosomes (MSC-Exos), as bioactive factor carriers, have promising results in cell-free therapy of OA. This study reviewed the application of various MSC-Exos for the OA treatment, along with exploring the potential underlying mechanisms. Moreover, current strategies and future perspectives for the utilization of engineered MSC-Exos, alongside their associated challenges, were also discussed.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1309946/fullexosomesosteoarthritismesenchymal stem cellstissue engineeringcartilage regeneration |
| spellingShingle | Danni Luo Hao Zhu Song Li Zhenggang Wang Jun Xiao Mesenchymal stem cell-derived exosomes as a promising cell-free therapy for knee osteoarthritis Frontiers in Bioengineering and Biotechnology exosomes osteoarthritis mesenchymal stem cells tissue engineering cartilage regeneration |
| title | Mesenchymal stem cell-derived exosomes as a promising cell-free therapy for knee osteoarthritis |
| title_full | Mesenchymal stem cell-derived exosomes as a promising cell-free therapy for knee osteoarthritis |
| title_fullStr | Mesenchymal stem cell-derived exosomes as a promising cell-free therapy for knee osteoarthritis |
| title_full_unstemmed | Mesenchymal stem cell-derived exosomes as a promising cell-free therapy for knee osteoarthritis |
| title_short | Mesenchymal stem cell-derived exosomes as a promising cell-free therapy for knee osteoarthritis |
| title_sort | mesenchymal stem cell derived exosomes as a promising cell free therapy for knee osteoarthritis |
| topic | exosomes osteoarthritis mesenchymal stem cells tissue engineering cartilage regeneration |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1309946/full |
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