In-hospital mortality predictors among hospitalized adults and those with chronic kidney disease with dengue
Background: Accurately identifying risk factors that predict fatality in dengue is crucial for patient triage and clinical management. Our objective was to identify predictors of death associated with dengue and investigate the clinical characteristics and risk factors among patients with chronic ki...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Journal of Microbiology, Immunology and Infection |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S168411822300155X |
| _version_ | 1797666068755382272 |
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| author | Ing-Kit Lee Nan-Yao Lee Wen-Chi Huang Jui-Chi Hsu Chien-Hsiang Tai Cheng Hsun Yang Chung-Hao Huang Chun-Yu Lin Ko Chang Yen-Hsu Chen |
| author_facet | Ing-Kit Lee Nan-Yao Lee Wen-Chi Huang Jui-Chi Hsu Chien-Hsiang Tai Cheng Hsun Yang Chung-Hao Huang Chun-Yu Lin Ko Chang Yen-Hsu Chen |
| author_sort | Ing-Kit Lee |
| collection | DOAJ |
| description | Background: Accurately identifying risk factors that predict fatality in dengue is crucial for patient triage and clinical management. Our objective was to identify predictors of death associated with dengue and investigate the clinical characteristics and risk factors among patients with chronic kidney disease (CKD) who died from dengue. Methods: A multicenter longitudinal observation study conducted from 2008 to 2019. Results: A total of 1272 patients (113 who died and 1186 who recovered) diagnosed with dengue were included. Old age, CKD, and an elevated white blood cell count at hospital presentation were identified as independent predictors of in-hospital mortality among individuals infected with the dengue virus. In a subgroup analysis of 138 patients with CKD infected with dengue virus, 64 (46.3%) patients died, with 46 (33.3%) patients dying within 7 days after symptom onset. Among 64 fatal dengue patients with CKD, 34.4% were in stages 2 and 3 of kidney disease, 51.5% were in stages 4 and 5, and 14.1% had end stage renal disease as per the classification by Kidney Disease Improving Global Outcomes. Multivariate analysis revealed that initial altered consciousness, pulmonary edema, and leukocytosis during hospitalization were independently associated with in-hospital mortality in CKD patients infected with the dengue virus. Leukocytosis during hospitalization and severe hepatitis were independent risk factors for death within 7 days after dengue illness onset in CKD patients. Conclusions: This study offers valuable insights into predictors linked to fatality in dengue and reinforces the importance of optimizing patient triage to improve the quality of care. |
| first_indexed | 2024-03-11T19:52:53Z |
| format | Article |
| id | doaj.art-ff02cdba56e8433486413c8fe58c402e |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-03-11T19:52:53Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-ff02cdba56e8433486413c8fe58c402e2023-10-05T04:23:00ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822023-10-015659961006In-hospital mortality predictors among hospitalized adults and those with chronic kidney disease with dengueIng-Kit Lee0Nan-Yao Lee1Wen-Chi Huang2Jui-Chi Hsu3Chien-Hsiang Tai4Cheng Hsun Yang5Chung-Hao Huang6Chun-Yu Lin7Ko Chang8Yen-Hsu Chen9Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Corresponding author. Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.Division of Infectious Diseases, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Center for Tropical Medicine and Infectious Disease Research, School of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan; College of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan; Corresponding author. Division of Infectious Diseases, Department of Internal Medicine, Center for Tropical Medicine and Infectious Disease Research, School of Medicine, College of medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.Background: Accurately identifying risk factors that predict fatality in dengue is crucial for patient triage and clinical management. Our objective was to identify predictors of death associated with dengue and investigate the clinical characteristics and risk factors among patients with chronic kidney disease (CKD) who died from dengue. Methods: A multicenter longitudinal observation study conducted from 2008 to 2019. Results: A total of 1272 patients (113 who died and 1186 who recovered) diagnosed with dengue were included. Old age, CKD, and an elevated white blood cell count at hospital presentation were identified as independent predictors of in-hospital mortality among individuals infected with the dengue virus. In a subgroup analysis of 138 patients with CKD infected with dengue virus, 64 (46.3%) patients died, with 46 (33.3%) patients dying within 7 days after symptom onset. Among 64 fatal dengue patients with CKD, 34.4% were in stages 2 and 3 of kidney disease, 51.5% were in stages 4 and 5, and 14.1% had end stage renal disease as per the classification by Kidney Disease Improving Global Outcomes. Multivariate analysis revealed that initial altered consciousness, pulmonary edema, and leukocytosis during hospitalization were independently associated with in-hospital mortality in CKD patients infected with the dengue virus. Leukocytosis during hospitalization and severe hepatitis were independent risk factors for death within 7 days after dengue illness onset in CKD patients. Conclusions: This study offers valuable insights into predictors linked to fatality in dengue and reinforces the importance of optimizing patient triage to improve the quality of care.http://www.sciencedirect.com/science/article/pii/S168411822300155XDengueChronic kidney diseaseMortalityRisk factor |
| spellingShingle | Ing-Kit Lee Nan-Yao Lee Wen-Chi Huang Jui-Chi Hsu Chien-Hsiang Tai Cheng Hsun Yang Chung-Hao Huang Chun-Yu Lin Ko Chang Yen-Hsu Chen In-hospital mortality predictors among hospitalized adults and those with chronic kidney disease with dengue Journal of Microbiology, Immunology and Infection Dengue Chronic kidney disease Mortality Risk factor |
| title | In-hospital mortality predictors among hospitalized adults and those with chronic kidney disease with dengue |
| title_full | In-hospital mortality predictors among hospitalized adults and those with chronic kidney disease with dengue |
| title_fullStr | In-hospital mortality predictors among hospitalized adults and those with chronic kidney disease with dengue |
| title_full_unstemmed | In-hospital mortality predictors among hospitalized adults and those with chronic kidney disease with dengue |
| title_short | In-hospital mortality predictors among hospitalized adults and those with chronic kidney disease with dengue |
| title_sort | in hospital mortality predictors among hospitalized adults and those with chronic kidney disease with dengue |
| topic | Dengue Chronic kidney disease Mortality Risk factor |
| url | http://www.sciencedirect.com/science/article/pii/S168411822300155X |
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