Spotted Fever Group Rickettsia Trigger Species-Specific Alterations in Macrophage Proteome Signatures with Different Impacts in Host Innate Inflammatory Responses

Spotted Fever Group Rickettsia Trigger Species-Specific Alterations in Macrophage Proteome Signatures with Different Impacts in Host Innate Inflammatory Responses

ABSTRACT The molecular details underlying differences in pathogenicity between Rickettsia species remain to be fully understood. Evidence points to macrophage permissiveness as a key mechanism in rickettsial virulence. Different studies have shown that several rickettsial species responsible for mil...

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Bibliographic Details
Main Authors: Pedro Curto, Cátia Santa, Luísa Cortes, Bruno Manadas, Isaura Simões
Format: Article
Language:English
Published: American Society for Microbiology 2021-12-01
Series:Microbiology Spectrum
Subjects:
SFG Rickettsia
obligate intracellular bacteria
macrophage permissiveness
immune evasion
host-pathogen interactions
pathogenicity
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00814-21

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