Synthesis, characterization, thermokinetic analysis and biological application of novel allyl glucosamine based glycopolymers
The synthesis of glycopolymers by copolymerising an allyl glucosamine (AG) monomer with co-monomers methyl methacrylate (MMA), acrylonitrile (AN) and 2-hydroxyethyl methacrylate (HEMA) was investigated via free-radical polymerisation of 2,2-azobisisobutyronitrile (AIBN) in dimethylformamide (DMF). T...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Designed Monomers and Polymers |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15685551.2023.2199506 |
| _version_ | 1797392437636759552 |
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| author | Yeliz Yıldırım Fatma Telli Erkan Kahraman John M. Gardiner |
| author_facet | Yeliz Yıldırım Fatma Telli Erkan Kahraman John M. Gardiner |
| author_sort | Yeliz Yıldırım |
| collection | DOAJ |
| description | The synthesis of glycopolymers by copolymerising an allyl glucosamine (AG) monomer with co-monomers methyl methacrylate (MMA), acrylonitrile (AN) and 2-hydroxyethyl methacrylate (HEMA) was investigated via free-radical polymerisation of 2,2-azobisisobutyronitrile (AIBN) in dimethylformamide (DMF). Three new copolymers, poly(AG-co-MMA), poly(AG-co-AN) and poly(AG-co-HEMA), were obtained. The chemical structures of the glycopolymers were analysed using 1H-NMR, 13C-NMR and FTIR. The thermal properties and degradation kinetics of the three glycopolymers were examined by thermogravimetric (TG) analysis at different heating rates. The effects of different co-monomers on the copolymerisation yield, thermal properties and biological activities of the resulting glycopolymers were investigated. The activation energies of the decomposition stages were calculated using the Flynn–Wall–Ozawa (FWO) and Kissinger methods. Furthermore, the biological activity of AG monomers and glycopolymers was studied and compared to chitosan. Poly(AG-co-HEMA) had the most significant effect on MCF-7 cell viability, and all glycopolymers have a low toxic effect profile on MCF-7 cell lines. |
| first_indexed | 2024-03-08T23:48:22Z |
| format | Article |
| id | doaj.art-ff039db5df1e4da8b44ac78354076db5 |
| institution | Directory Open Access Journal |
| issn | 1385-772X 1568-5551 |
| language | English |
| last_indexed | 2024-03-08T23:48:22Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Designed Monomers and Polymers |
| spelling | doaj.art-ff039db5df1e4da8b44ac78354076db52023-12-13T15:41:09ZengTaylor & Francis GroupDesigned Monomers and Polymers1385-772X1568-55512023-12-0126111713110.1080/15685551.2023.21995062199506Synthesis, characterization, thermokinetic analysis and biological application of novel allyl glucosamine based glycopolymersYeliz Yıldırım0Fatma Telli1Erkan Kahraman2John M. Gardiner3Ege UniversityEge UniversityEge UniversityDepartment of Chemistry, School of Natural Science University of ManchesterThe synthesis of glycopolymers by copolymerising an allyl glucosamine (AG) monomer with co-monomers methyl methacrylate (MMA), acrylonitrile (AN) and 2-hydroxyethyl methacrylate (HEMA) was investigated via free-radical polymerisation of 2,2-azobisisobutyronitrile (AIBN) in dimethylformamide (DMF). Three new copolymers, poly(AG-co-MMA), poly(AG-co-AN) and poly(AG-co-HEMA), were obtained. The chemical structures of the glycopolymers were analysed using 1H-NMR, 13C-NMR and FTIR. The thermal properties and degradation kinetics of the three glycopolymers were examined by thermogravimetric (TG) analysis at different heating rates. The effects of different co-monomers on the copolymerisation yield, thermal properties and biological activities of the resulting glycopolymers were investigated. The activation energies of the decomposition stages were calculated using the Flynn–Wall–Ozawa (FWO) and Kissinger methods. Furthermore, the biological activity of AG monomers and glycopolymers was studied and compared to chitosan. Poly(AG-co-HEMA) had the most significant effect on MCF-7 cell viability, and all glycopolymers have a low toxic effect profile on MCF-7 cell lines.http://dx.doi.org/10.1080/15685551.2023.2199506glycopolymerscarbohydrate-based allyl copolymerdecomposition kineticthermal analysisbiological applications |
| spellingShingle | Yeliz Yıldırım Fatma Telli Erkan Kahraman John M. Gardiner Synthesis, characterization, thermokinetic analysis and biological application of novel allyl glucosamine based glycopolymers Designed Monomers and Polymers glycopolymers carbohydrate-based allyl copolymer decomposition kinetic thermal analysis biological applications |
| title | Synthesis, characterization, thermokinetic analysis and biological application of novel allyl glucosamine based glycopolymers |
| title_full | Synthesis, characterization, thermokinetic analysis and biological application of novel allyl glucosamine based glycopolymers |
| title_fullStr | Synthesis, characterization, thermokinetic analysis and biological application of novel allyl glucosamine based glycopolymers |
| title_full_unstemmed | Synthesis, characterization, thermokinetic analysis and biological application of novel allyl glucosamine based glycopolymers |
| title_short | Synthesis, characterization, thermokinetic analysis and biological application of novel allyl glucosamine based glycopolymers |
| title_sort | synthesis characterization thermokinetic analysis and biological application of novel allyl glucosamine based glycopolymers |
| topic | glycopolymers carbohydrate-based allyl copolymer decomposition kinetic thermal analysis biological applications |
| url | http://dx.doi.org/10.1080/15685551.2023.2199506 |
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