“CONTRAST” STUDY: COMPARİSİON OF NEPHROPROTECTİVE THREE PROTOCOLS: ACETYLCYSTEİNESODİUM BİCARBONATE-THEOPHYLLİNE, TO PREVENT CONTRAST-İNDUCED NEPHROPATHY
Aim. The purpose of this study was to compare three prophylactic regimens, sodium-bicarbonate based hydration, sodium-bicarbonate + N-acetylcysteine (NAC), and sodium-bicarbonate + NAC + theophylline, for the prevention of contrast induced nephropathy.Material and methods. We prospectively randomize...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2014-01-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/587 |
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| author | Ilker Murat Caglar Fatma Nihan Turhan Caglar Cenk Conkbayir Murat Baskurt Faruk Akturk Tolga Dasli Baris Okcun |
| author_facet | Ilker Murat Caglar Fatma Nihan Turhan Caglar Cenk Conkbayir Murat Baskurt Faruk Akturk Tolga Dasli Baris Okcun |
| author_sort | Ilker Murat Caglar |
| collection | DOAJ |
| description | Aim. The purpose of this study was to compare three prophylactic regimens, sodium-bicarbonate based hydration, sodium-bicarbonate + N-acetylcysteine (NAC), and sodium-bicarbonate + NAC + theophylline, for the prevention of contrast induced nephropathy.Material and methods. We prospectively randomized 151 patients with baseline eGFR values between 30–59 ml/min/1.73m² who were also undergoing coronary angiography with three prophylactic treatments: intravenous hydration with sodiumbicarbonate (3 ml/kg/h for 1 hours before and 1 ml/kg/h for 6 hours after contrast exposure, group 1; n=50), hydration + NAC (600 mg p. o. twice daily the preceding day and the day of angiography, group 2; n=50), and hydration + NAC + theophylline (600 mg p. o. NAC and 200 mg theophylline p. o. twice daily for the preceding day and the day of angiography, group 3; n=51). The incidence of contrast induced nephropathy (0,5 mg/dl increase in serum creatinine from the baseline value 48 hours after intravascular injection of contrast) from the three groups was compared.Results. Of the 151 patients, 4 patients (7.8%) in group 3 experienced CIN (p=0.01). CIN did not develop in group 1 and 2.Conclusion. Among patients with eGFR values between 30–59 ml/min/1.73m² undergoing coronary angiography, use of sodium-bicarbonate based hydration alone and sodium-bicarbonate with NAC was associated with a reduction in the rate of contrast induced nephropathy. Sodium-bicarbonate with theophylline therapy was found to have no effect for the prevention of contrast-induced nephropathy. |
| first_indexed | 2024-04-09T20:51:36Z |
| format | Article |
| id | doaj.art-ff03aa0d612243e7bff08842987fd358 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2025-03-14T09:32:37Z |
| publishDate | 2014-01-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-ff03aa0d612243e7bff08842987fd3582025-03-02T11:42:33Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202014-01-0101-ENG273110.15829/1560-4071-2014-1-ENG-27-31534“CONTRAST” STUDY: COMPARİSİON OF NEPHROPROTECTİVE THREE PROTOCOLS: ACETYLCYSTEİNESODİUM BİCARBONATE-THEOPHYLLİNE, TO PREVENT CONTRAST-İNDUCED NEPHROPATHYIlker Murat Caglar0Fatma Nihan Turhan Caglar1Cenk Conkbayir2Murat Baskurt3Faruk Akturk4Tolga Dasli5Baris Okcun6Dr.Sadi konuk bakirkoy education and research hospital, cardiology department, Bakırkoy, Istanbul, TurkeyIstanbul Education and research hospital, cardiology department, Fatih, Istanbul, Turkey3Near East university, cardiology department, Nicosia (North), CyprusMedicana hospital, cardiology department, Bahcelievler, Istanbul, TurkeyMehmet akif ersoy education and research hospital, cardiology department, Halkali, Istanbul, TurkeyEyup state hospital, cardiology department, Eyup, Istanbul, TurkeyIstanbul university cardiology institute, cardiology department, Fatih, Istanbul, TurkeyAim. The purpose of this study was to compare three prophylactic regimens, sodium-bicarbonate based hydration, sodium-bicarbonate + N-acetylcysteine (NAC), and sodium-bicarbonate + NAC + theophylline, for the prevention of contrast induced nephropathy.Material and methods. We prospectively randomized 151 patients with baseline eGFR values between 30–59 ml/min/1.73m² who were also undergoing coronary angiography with three prophylactic treatments: intravenous hydration with sodiumbicarbonate (3 ml/kg/h for 1 hours before and 1 ml/kg/h for 6 hours after contrast exposure, group 1; n=50), hydration + NAC (600 mg p. o. twice daily the preceding day and the day of angiography, group 2; n=50), and hydration + NAC + theophylline (600 mg p. o. NAC and 200 mg theophylline p. o. twice daily for the preceding day and the day of angiography, group 3; n=51). The incidence of contrast induced nephropathy (0,5 mg/dl increase in serum creatinine from the baseline value 48 hours after intravascular injection of contrast) from the three groups was compared.Results. Of the 151 patients, 4 patients (7.8%) in group 3 experienced CIN (p=0.01). CIN did not develop in group 1 and 2.Conclusion. Among patients with eGFR values between 30–59 ml/min/1.73m² undergoing coronary angiography, use of sodium-bicarbonate based hydration alone and sodium-bicarbonate with NAC was associated with a reduction in the rate of contrast induced nephropathy. Sodium-bicarbonate with theophylline therapy was found to have no effect for the prevention of contrast-induced nephropathy.https://russjcardiol.elpub.ru/jour/article/view/587contrast nephropathyangiography |
| spellingShingle | Ilker Murat Caglar Fatma Nihan Turhan Caglar Cenk Conkbayir Murat Baskurt Faruk Akturk Tolga Dasli Baris Okcun “CONTRAST” STUDY: COMPARİSİON OF NEPHROPROTECTİVE THREE PROTOCOLS: ACETYLCYSTEİNESODİUM BİCARBONATE-THEOPHYLLİNE, TO PREVENT CONTRAST-İNDUCED NEPHROPATHY Российский кардиологический журнал contrast nephropathy angiography |
| title | “CONTRAST” STUDY: COMPARİSİON OF NEPHROPROTECTİVE THREE PROTOCOLS: ACETYLCYSTEİNESODİUM BİCARBONATE-THEOPHYLLİNE, TO PREVENT CONTRAST-İNDUCED NEPHROPATHY |
| title_full | “CONTRAST” STUDY: COMPARİSİON OF NEPHROPROTECTİVE THREE PROTOCOLS: ACETYLCYSTEİNESODİUM BİCARBONATE-THEOPHYLLİNE, TO PREVENT CONTRAST-İNDUCED NEPHROPATHY |
| title_fullStr | “CONTRAST” STUDY: COMPARİSİON OF NEPHROPROTECTİVE THREE PROTOCOLS: ACETYLCYSTEİNESODİUM BİCARBONATE-THEOPHYLLİNE, TO PREVENT CONTRAST-İNDUCED NEPHROPATHY |
| title_full_unstemmed | “CONTRAST” STUDY: COMPARİSİON OF NEPHROPROTECTİVE THREE PROTOCOLS: ACETYLCYSTEİNESODİUM BİCARBONATE-THEOPHYLLİNE, TO PREVENT CONTRAST-İNDUCED NEPHROPATHY |
| title_short | “CONTRAST” STUDY: COMPARİSİON OF NEPHROPROTECTİVE THREE PROTOCOLS: ACETYLCYSTEİNESODİUM BİCARBONATE-THEOPHYLLİNE, TO PREVENT CONTRAST-İNDUCED NEPHROPATHY |
| title_sort | contrast study comparision of nephroprotective three protocols acetylcysteinesodium bicarbonate theophylline to prevent contrast induced nephropathy |
| topic | contrast nephropathy angiography |
| url | https://russjcardiol.elpub.ru/jour/article/view/587 |
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