Adiponectin, biomarkers of inflammation and changes in cardiac autonomic function: Whitehall II study
Abstract Background Biomarkers of inflammation and adiponectin are associated with cardiovascular autonomic neuropathy (CAN) in cross-sectional studies, but prospective data are scarce. This study aimed to assess the associations of biomarkers of subclinical inflammation and adiponectin with subsequ...
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| Format: | Article |
| Language: | English |
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BMC
2017-12-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12933-017-0634-3 |
| _version_ | 1819010932718698496 |
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| author | Christian Stevns Hansen Dorte Vistisen Marit Eika Jørgensen Daniel R. Witte Eric J. Brunner Adam G. Tabák Mika Kivimäki Michael Roden Marek Malik Christian Herder |
| author_facet | Christian Stevns Hansen Dorte Vistisen Marit Eika Jørgensen Daniel R. Witte Eric J. Brunner Adam G. Tabák Mika Kivimäki Michael Roden Marek Malik Christian Herder |
| author_sort | Christian Stevns Hansen |
| collection | DOAJ |
| description | Abstract Background Biomarkers of inflammation and adiponectin are associated with cardiovascular autonomic neuropathy (CAN) in cross-sectional studies, but prospective data are scarce. This study aimed to assess the associations of biomarkers of subclinical inflammation and adiponectin with subsequent changes in heart rate (HR) and heart rate variability (HRV) in non-diabetic and diabetic individuals. Methods Data are based on up to 25,050 person-examinations for 8469 study participants of the Whitehall II cohort study. Measures of CAN included HR and several HRV indices. Associations between baseline serum levels of high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, IL-1 receptor antagonist (IL-1Ra) and adiponectin and 5-year changes in HR and six HRV indices were estimated using mixed-effects models adjusting for age, sex, ethnicity, body mass index (BMI), metabolic covariates and medication. A modifying effect of diabetes was tested. Results Higher levels of IL-1Ra were associated with higher increases in HR. Additional associations with measures of HRV were observed for hsCRP, IL-6 and IL-1Ra, but these associations were explained by BMI and other confounders. Associations between adiponectin, HR and HRV differed depending on diabetes status. Higher adiponectin levels were associated with more pronounced decreases in HR and increases in three measures of HRV reflecting both sympathetic and vagal activity, but these findings were limited to individuals with type 2 diabetes. Conclusions Higher IL-1Ra levels appeared as novel risk marker for increases in HR. Higher adiponectin levels were associated with a more favourable development of cardiovascular autonomic function in individuals with type 2 diabetes independently of multiple confounders. |
| first_indexed | 2024-12-21T01:20:07Z |
| format | Article |
| id | doaj.art-ff04182f5c334849919e54e3d4030e84 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-21T01:20:07Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-ff04182f5c334849919e54e3d4030e842022-12-21T19:20:41ZengBMCCardiovascular Diabetology1475-28402017-12-011611910.1186/s12933-017-0634-3Adiponectin, biomarkers of inflammation and changes in cardiac autonomic function: Whitehall II studyChristian Stevns Hansen0Dorte Vistisen1Marit Eika Jørgensen2Daniel R. Witte3Eric J. Brunner4Adam G. Tabák5Mika Kivimäki6Michael Roden7Marek Malik8Christian Herder9Steno Diabetes Center CopenhagenSteno Diabetes Center CopenhagenSteno Diabetes Center CopenhagenDepartment of Public Health, Aarhus UniversityDepartment of Epidemiology and Public Health, University College LondonDepartment of Epidemiology and Public Health, University College LondonDepartment of Epidemiology and Public Health, University College LondonInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfNational Heart and Lung Institute, Imperial CollegeInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfAbstract Background Biomarkers of inflammation and adiponectin are associated with cardiovascular autonomic neuropathy (CAN) in cross-sectional studies, but prospective data are scarce. This study aimed to assess the associations of biomarkers of subclinical inflammation and adiponectin with subsequent changes in heart rate (HR) and heart rate variability (HRV) in non-diabetic and diabetic individuals. Methods Data are based on up to 25,050 person-examinations for 8469 study participants of the Whitehall II cohort study. Measures of CAN included HR and several HRV indices. Associations between baseline serum levels of high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, IL-1 receptor antagonist (IL-1Ra) and adiponectin and 5-year changes in HR and six HRV indices were estimated using mixed-effects models adjusting for age, sex, ethnicity, body mass index (BMI), metabolic covariates and medication. A modifying effect of diabetes was tested. Results Higher levels of IL-1Ra were associated with higher increases in HR. Additional associations with measures of HRV were observed for hsCRP, IL-6 and IL-1Ra, but these associations were explained by BMI and other confounders. Associations between adiponectin, HR and HRV differed depending on diabetes status. Higher adiponectin levels were associated with more pronounced decreases in HR and increases in three measures of HRV reflecting both sympathetic and vagal activity, but these findings were limited to individuals with type 2 diabetes. Conclusions Higher IL-1Ra levels appeared as novel risk marker for increases in HR. Higher adiponectin levels were associated with a more favourable development of cardiovascular autonomic function in individuals with type 2 diabetes independently of multiple confounders.http://link.springer.com/article/10.1186/s12933-017-0634-3Cardiovascular diseaseCardiovascular autonomic neuropathyHeart rateInflammationAdipokinePrediction |
| spellingShingle | Christian Stevns Hansen Dorte Vistisen Marit Eika Jørgensen Daniel R. Witte Eric J. Brunner Adam G. Tabák Mika Kivimäki Michael Roden Marek Malik Christian Herder Adiponectin, biomarkers of inflammation and changes in cardiac autonomic function: Whitehall II study Cardiovascular Diabetology Cardiovascular disease Cardiovascular autonomic neuropathy Heart rate Inflammation Adipokine Prediction |
| title | Adiponectin, biomarkers of inflammation and changes in cardiac autonomic function: Whitehall II study |
| title_full | Adiponectin, biomarkers of inflammation and changes in cardiac autonomic function: Whitehall II study |
| title_fullStr | Adiponectin, biomarkers of inflammation and changes in cardiac autonomic function: Whitehall II study |
| title_full_unstemmed | Adiponectin, biomarkers of inflammation and changes in cardiac autonomic function: Whitehall II study |
| title_short | Adiponectin, biomarkers of inflammation and changes in cardiac autonomic function: Whitehall II study |
| title_sort | adiponectin biomarkers of inflammation and changes in cardiac autonomic function whitehall ii study |
| topic | Cardiovascular disease Cardiovascular autonomic neuropathy Heart rate Inflammation Adipokine Prediction |
| url | http://link.springer.com/article/10.1186/s12933-017-0634-3 |
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