ECM-derived biomaterials for regulating tissue multicellularity and maturation
Summary: Recent breakthroughs in developing human-relevant organotypic models led to the building of highly resemblant tissue constructs that hold immense potential for transplantation, drug screening, and disease modeling. Despite the progress in fine-tuning stem cell multilineage differentiation i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224003626 |
| _version_ | 1797302513883414528 |
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| author | Ali Smandri Maimonah Eissa Al-Masawa Ng Min Hwei Mh Busra Fauzi |
| author_facet | Ali Smandri Maimonah Eissa Al-Masawa Ng Min Hwei Mh Busra Fauzi |
| author_sort | Ali Smandri |
| collection | DOAJ |
| description | Summary: Recent breakthroughs in developing human-relevant organotypic models led to the building of highly resemblant tissue constructs that hold immense potential for transplantation, drug screening, and disease modeling. Despite the progress in fine-tuning stem cell multilineage differentiation in highly controlled spatiotemporal conditions and hosting microenvironments, 3D models still experience naive and incomplete morphogenesis. In particular, existing systems and induction protocols fail to maintain stem cell long-term potency, induce high tissue-level multicellularity, or drive the maturity of stem cell-derived 3D models to levels seen in their in vivo counterparts. In this review, we highlight the use of extracellular matrix (ECM)-derived biomaterials in providing stem cell niche-mimicking microenvironment capable of preserving stem cell long-term potency and inducing spatial and region-specific differentiation. We also examine the maturation of different 3D models, including organoids, encapsulated in ECM biomaterials and provide looking-forward perspectives on employing ECM biomaterials in building more innovative, transplantable, and functional organs. |
| first_indexed | 2024-03-07T23:38:55Z |
| format | Article |
| id | doaj.art-ff049f5fc69d4f35bbeaf5e91d6391d8 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-07T23:38:55Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-ff049f5fc69d4f35bbeaf5e91d6391d82024-02-20T04:19:34ZengElsevieriScience2589-00422024-03-01273109141ECM-derived biomaterials for regulating tissue multicellularity and maturationAli Smandri0Maimonah Eissa Al-Masawa1Ng Min Hwei2Mh Busra Fauzi3Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, MalaysiaCentre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, MalaysiaCentre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, MalaysiaCentre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia; Corresponding authorSummary: Recent breakthroughs in developing human-relevant organotypic models led to the building of highly resemblant tissue constructs that hold immense potential for transplantation, drug screening, and disease modeling. Despite the progress in fine-tuning stem cell multilineage differentiation in highly controlled spatiotemporal conditions and hosting microenvironments, 3D models still experience naive and incomplete morphogenesis. In particular, existing systems and induction protocols fail to maintain stem cell long-term potency, induce high tissue-level multicellularity, or drive the maturity of stem cell-derived 3D models to levels seen in their in vivo counterparts. In this review, we highlight the use of extracellular matrix (ECM)-derived biomaterials in providing stem cell niche-mimicking microenvironment capable of preserving stem cell long-term potency and inducing spatial and region-specific differentiation. We also examine the maturation of different 3D models, including organoids, encapsulated in ECM biomaterials and provide looking-forward perspectives on employing ECM biomaterials in building more innovative, transplantable, and functional organs.http://www.sciencedirect.com/science/article/pii/S2589004224003626Biological sciencesTissue engineering |
| spellingShingle | Ali Smandri Maimonah Eissa Al-Masawa Ng Min Hwei Mh Busra Fauzi ECM-derived biomaterials for regulating tissue multicellularity and maturation iScience Biological sciences Tissue engineering |
| title | ECM-derived biomaterials for regulating tissue multicellularity and maturation |
| title_full | ECM-derived biomaterials for regulating tissue multicellularity and maturation |
| title_fullStr | ECM-derived biomaterials for regulating tissue multicellularity and maturation |
| title_full_unstemmed | ECM-derived biomaterials for regulating tissue multicellularity and maturation |
| title_short | ECM-derived biomaterials for regulating tissue multicellularity and maturation |
| title_sort | ecm derived biomaterials for regulating tissue multicellularity and maturation |
| topic | Biological sciences Tissue engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224003626 |
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