Predictive value of immunoglobulin G, activated partial thromboplastin time, platelet, and indirect bilirubin for delayed viral clearance in patients infected with the Omicron variant
Background Omicron is the recently emerged highly transmissible severe acute respiratory syndrome coronavirus 2 variant that has caused a dramatic increase in coronavirus disease-2019 infection cases worldwide. This study was to investigate the association between demographic and laboratory findings...
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PeerJ Inc.
2023-05-01
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| Online Access: | https://peerj.com/articles/15443.pdf |
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| author | Lina Zhang Shucai Xie Feng Lyu Chun Liu Chunhui Li Wei Liu Xinhua Ma Jieyu Zhou Xinyu Qian Yong Lu Zhaoxin Qian |
| author_facet | Lina Zhang Shucai Xie Feng Lyu Chun Liu Chunhui Li Wei Liu Xinhua Ma Jieyu Zhou Xinyu Qian Yong Lu Zhaoxin Qian |
| author_sort | Lina Zhang |
| collection | DOAJ |
| description | Background Omicron is the recently emerged highly transmissible severe acute respiratory syndrome coronavirus 2 variant that has caused a dramatic increase in coronavirus disease-2019 infection cases worldwide. This study was to investigate the association between demographic and laboratory findings, and the duration of Omicron viral clearance. Methods Approximately 278 Omicron cases at the Ruijin Hospital Luwan Branch, Shanghai Jiaotong University School of Medicine were retrospectively analyzed between August 11 and August 31, 2022. Demographic and laboratory data were also collected. The association between demographics, laboratory findings, and duration of Omicron viral clearance was analyzed using Pearson correlation analysis and univariate and multivariate logistic regression. Results Univariate logistic regression analyses showed that a prolonged viral clearance time was significantly associated with older age and lower immunoglobulin (Ig) G and platelet (PLT) levels. Using multinomial logistic regression analyses, direct bilirubin, IgG, activated partial thromboplastin time (APTT), and PLT were independent factors for longer viral shedding duration. The model combining direct bilirubin, IgG, APTT, and PLT identifies patients infected with Omicron whose viral clearance time was ≥7 days with 62.7% sensitivity and 83.4% specificity. Conclusion These findings suggest that direct bilirubin, IgG, PLT, and APTT are significant risk factors for a longer viral shedding duration in patients infected with Omicron. Measuring levels of direct bilirubin, IgG, PLT, and APTT is advantageous to identify patients infected with Omicron with longer viral shedding duration. |
| first_indexed | 2024-03-09T04:12:17Z |
| format | Article |
| id | doaj.art-ff04b7a976114ed3a923c1157e70b5a0 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T04:12:17Z |
| publishDate | 2023-05-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-ff04b7a976114ed3a923c1157e70b5a02023-12-03T13:59:13ZengPeerJ Inc.PeerJ2167-83592023-05-0111e1544310.7717/peerj.15443Predictive value of immunoglobulin G, activated partial thromboplastin time, platelet, and indirect bilirubin for delayed viral clearance in patients infected with the Omicron variantLina Zhang0Shucai Xie1Feng Lyu2Chun Liu3Chunhui Li4Wei Liu5Xinhua Ma6Jieyu Zhou7Xinyu Qian8Yong Lu9Zhaoxin Qian10Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaSchool of Computer Science and Engineering, Central South University, Changsha, Hunan, ChinaRespiratory and Critical Care Medicine Department, The Third Xiangya Hospital of Central South University, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaSchool of Computer Science and Engineering, Central South University, Changsha, Hunan, ChinaSchool of Computer Science and Engineering, Central South University, Changsha, Hunan, ChinaDepartment of Radiology, Ruijin Hospital Luwan Branch, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaBackground Omicron is the recently emerged highly transmissible severe acute respiratory syndrome coronavirus 2 variant that has caused a dramatic increase in coronavirus disease-2019 infection cases worldwide. This study was to investigate the association between demographic and laboratory findings, and the duration of Omicron viral clearance. Methods Approximately 278 Omicron cases at the Ruijin Hospital Luwan Branch, Shanghai Jiaotong University School of Medicine were retrospectively analyzed between August 11 and August 31, 2022. Demographic and laboratory data were also collected. The association between demographics, laboratory findings, and duration of Omicron viral clearance was analyzed using Pearson correlation analysis and univariate and multivariate logistic regression. Results Univariate logistic regression analyses showed that a prolonged viral clearance time was significantly associated with older age and lower immunoglobulin (Ig) G and platelet (PLT) levels. Using multinomial logistic regression analyses, direct bilirubin, IgG, activated partial thromboplastin time (APTT), and PLT were independent factors for longer viral shedding duration. The model combining direct bilirubin, IgG, APTT, and PLT identifies patients infected with Omicron whose viral clearance time was ≥7 days with 62.7% sensitivity and 83.4% specificity. Conclusion These findings suggest that direct bilirubin, IgG, PLT, and APTT are significant risk factors for a longer viral shedding duration in patients infected with Omicron. Measuring levels of direct bilirubin, IgG, PLT, and APTT is advantageous to identify patients infected with Omicron with longer viral shedding duration.https://peerj.com/articles/15443.pdfOmicronCOVID-19Viral clearanceImmunoglobulin GActivated partial thromboplastin timePlatelet |
| spellingShingle | Lina Zhang Shucai Xie Feng Lyu Chun Liu Chunhui Li Wei Liu Xinhua Ma Jieyu Zhou Xinyu Qian Yong Lu Zhaoxin Qian Predictive value of immunoglobulin G, activated partial thromboplastin time, platelet, and indirect bilirubin for delayed viral clearance in patients infected with the Omicron variant PeerJ Omicron COVID-19 Viral clearance Immunoglobulin G Activated partial thromboplastin time Platelet |
| title | Predictive value of immunoglobulin G, activated partial thromboplastin time, platelet, and indirect bilirubin for delayed viral clearance in patients infected with the Omicron variant |
| title_full | Predictive value of immunoglobulin G, activated partial thromboplastin time, platelet, and indirect bilirubin for delayed viral clearance in patients infected with the Omicron variant |
| title_fullStr | Predictive value of immunoglobulin G, activated partial thromboplastin time, platelet, and indirect bilirubin for delayed viral clearance in patients infected with the Omicron variant |
| title_full_unstemmed | Predictive value of immunoglobulin G, activated partial thromboplastin time, platelet, and indirect bilirubin for delayed viral clearance in patients infected with the Omicron variant |
| title_short | Predictive value of immunoglobulin G, activated partial thromboplastin time, platelet, and indirect bilirubin for delayed viral clearance in patients infected with the Omicron variant |
| title_sort | predictive value of immunoglobulin g activated partial thromboplastin time platelet and indirect bilirubin for delayed viral clearance in patients infected with the omicron variant |
| topic | Omicron COVID-19 Viral clearance Immunoglobulin G Activated partial thromboplastin time Platelet |
| url | https://peerj.com/articles/15443.pdf |
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